Discrete Subaortic Stenosis

A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the AORTIC VALVE, anywhere between the aortic valve and the MITRAL VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.

Also Known As:

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Left Ventricular Outflow Obstruction
2.	Bacterial Endocarditis
3.	Endocarditis

Experts

1.	Karangelis, Dimos: 1 article (09/2020)
2.	Loggos, Spiros: 1 article (09/2020)
3.	Mitropoulos, Fotios A: 1 article (09/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Discrete Subaortic Stenosis:

1.	CatecholaminesIBA 09/01/1988 - "The perioperative fate of residual gradients after repair of discrete subaortic stenosis and time-related blood levels of catecholamines."
2.	perfluoro- 2,2,2',2'- tetramethyl- 4,4'- bis(1,3- dioxolane)IBA 09/15/1986 - "Seven patients, mean age 8 +/- 3.6 years, with clinical and hemodynamic diagnoses of discrete subaortic stenosis were treated by percutaneous transluminal balloon dilatation (PTBD) of the membrane during cardiac catheterization. "
3.	A-factor (Streptomyces)IBA 01/01/1977 - "Bacterial endocarditis is very rare in patients with discrete subaortic stenosis, but it must be regarded as a factor complicating the natural history of cardiopathy."

Therapies and Procedures

1.	Myotomy 04/01/1999 - "For discrete subaortic stenosis (n = 120), 39 patients underwent isolated membranectomy, 67 underwent membranectomy with associated septal myotomy, and 14 underwent septal myectomy. " 11/01/1993 - "For patients with discrete subaortic stenosis, risk of late aortic insufficiency was 38.6% after isolated membranectomy, 27.8% after membranectomy and myotomy, and only 7.3% after membranectomy and myectomy (P < .004). " 09/01/1994 - "We conclude that in the surgical management of fixed discrete subaortic stenosis myectomy and myotomy in addition to membranectomy produces better relief of the left ventricular outflow obstruction than do membranectomy alone." 11/01/1986 - "We conclude that in the surgical management of discrete subaortic stenosis types I and II, deep myectomy (in addition to membranectomy) produces better relief of the left ventricular outflow obstruction than do membranectomy and myotomy. "
2.	Catheters 02/01/1996 - "A 37 year-old female patient underwent catheter-balloon dilation for discrete subaortic stenosis. " 08/01/1987 - "Catheter balloon dilatation for discrete subaortic stenosis in the adult."
3.	Sternotomy 09/01/2020 - "Surgery for discrete subaortic stenosis is most often performed through a typical midline sternotomy. "
4.	Therapeutics 09/01/1999 - "Membranectomy and myectomy are standard therapy for discrete subaortic stenosis (DS) and are associated with low rates of endocarditis, recurrence, and aortic insufficiency. "