|1.||Song, Linsheng: 11 articles (05/2012 - 02/2007)|
|2.||Qiu, Limei: 9 articles (05/2012 - 05/2008)|
|3.||Wang, Lingling: 9 articles (05/2012 - 05/2008)|
|4.||Zhao, Jianmin: 9 articles (05/2012 - 02/2007)|
|5.||Zhang, Huan: 9 articles (05/2012 - 01/2008)|
|6.||Pemberton, Chris J: 6 articles (12/2015 - 07/2010)|
|7.||Mentese, Ahmet: 6 articles (09/2015 - 01/2012)|
|8.||Pesonen, Ullamari: 6 articles (03/2007 - 05/2003)|
|9.||Koulu, Markku: 5 articles (03/2007 - 07/2003)|
|10.||Sun, Xiaofen: 5 articles (03/2007 - 06/2004)|
02/01/2011 - "For the present study, we designed lentivirus-mediated signal peptide TNF-α-Tumstatin(45-132) -expressing mesenchymal stem cells (SPTT-MSCs) as a novel anti-cancer approach. "
06/21/2008 - "In this study, we designed a secretory protein by adding a secretory signal peptide (SP) to the N terminus of Transactivating Transcription (TAT)-apoptin (SP-TAT-apoptin), to test the hypothesis that it gains an additive bystander effect as an anti-cancer therapy. "
09/01/2003 - "In the present study, we investigated the feasibility of modifying a cytokine signal peptide with a tumor antigenic epitope. "
07/01/2015 - "Additionally, the analysis of the PRL transcripts in lung tumors and cell lines revealed systematic truncations of their 5' regions, including the signal peptide-encoding portions. "
10/01/2014 - "Using a B2 deletion mutant, the B2 mitochondrial targeting signal sequence ((41)RTFVISAHAA(50)) correlated with mitochondrial free radical production and cell death in fish cells, embryonic zebrafish, and human cancer cells. "
|2.||Melanoma (Melanoma, Malignant)
04/01/2013 - "Similarly, WM-266-4 melanoma cells that express endogenous hUcn 2 secreted only the glycosylated prohormone lacking the signal peptide and unmodified at the C terminus. "
02/21/2007 - "KISS1 containing an internal FLAG epitope with (KFM) or without (KFMdeltaSS) a signal sequence was transfected into C8161.9 human melanoma cells, which do not express endogenous KISS1. "
03/02/2000 - "The high basal activity of the mda-7 promoter in uninduced melanoma cells and the absence of enhancing effect upon treatment with differentiation inducers is corroborated by transfection studies using the promoter region of mda-7 linked to a luciferase reporter gene containing the SV40 polyadenylation signal sequence. "
08/01/2000 - "We report here that the addition of synthetic signal sequences at the N terminus, but not at the C terminus, of an epitope from the human melanoma antigen MART-1 greatly enhances its presentation in both TAP-deficient and TAP-expressing cells. "
08/01/2000 - "Synthetic insertion signal sequences enhance MHC class I presentation of a peptide from the melanoma antigen MART-1."
04/01/2015 - "The C-terminal signal sequence facilitates secretion of SidJ into host cells at early points of infection, whereas the internal signal sequence mediates secretion at later time points. "
04/10/2014 - "White spot syndrome virus VP14 contains transmembrane and signal peptides domain, which is considered to be important for virus infection. "
01/01/2014 - "Here we review how the signal sequence of the GPI-anchor matters in PrP(C) localization, how an altered cellular localization of PrP(C) or differences in GPI-anchor composition can affect prion infection, and we discuss through which mechanisms changes on the anchorage of PrP(C) can modify the disease process."
12/01/2011 - "Finally, overexpression of the Vfr secretion signal sequence significantly decreased speB transcript level and attenuated GAS virulence in two mouse models of invasive infection. "
02/01/2011 - "The analysis of genes differentially expressed during infection revealed a significant enrichment of genes encoding expanded domains as well as signal peptides linking a substantial part of these genes to pathogenicity. "
01/01/2011 - "PvRON2 is a 2,204 residue-long protein encoded by a single 6,615 bp exon containing a hydrophobic signal sequence towards the amino-terminus, a transmembrane domain towards the carboxy-terminus and two coiled coil α-helical motifs; these are characteristic features of several previously described vaccine candidates against malaria. "
02/21/2003 - "The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites."
02/09/2007 - "Previous studies have shown that the immunogenicity of rodent malaria parasite-derived circumsporozoite protein (CS) can be improved by deleting the glycosyl-phosphatidyl-inositol (GPI) signal sequence. "
10/01/2006 - "Similar to other oomycete avirulence proteins, AVR3aKI carries a signal peptide followed by a conserved motif centered on the consensus RXLR sequence that is functionally similar to a host cell-targeting signal of malaria parasites. "
04/01/2004 - "A gene encoding a 352 amino acid protein with a putative signal sequence, transmembrane domain and thrombospondin structural homology repeat was identified in the genome of the human malaria parasite, Plasmodium falciparum and the rodent malaria parasite, Plasmodium berghei. "
|5.||Dehydration (Water Stress)
12/01/2006 - "The extent of NisB-mediated dehydration could be improved by raising the intracellular concentration NisB or by modulating the export efficiency through altering the signal sequence. "
10/04/2011 - "On the other hand, studies showed that the C-terminal part of the leader peptide serves as a spacer between the binding site and active sites for phosphorylation and elimination, thus restricting the number of hydroxy amino acid side chains that could undergo dehydration. "
11/05/2012 - "Notably, by expressing the leader peptide in trans together with the leaderless prenisin, we were able to increase the dehydration/cyclization efficiency of both NisB and NisC, but still with limited efficiency until the fifth dehydratable residue (Thr13) was processed, thereby enabling three rings to form. "
01/01/2011 - "Reducing the leader peptide to MSTKDFNLDLR led to 3- or 4-fold dehydration. "
07/15/2008 - "However, introduction of Pro residues into the leader peptide strongly affected the efficiency of dehydration, consistent with recognition of the secondary structure of the leader peptide by the synthetase. "
|3.||DNA (Deoxyribonucleic Acid)
|4.||Messenger RNA (mRNA)
|5.||A-Form DNA (A-DNA)
|6.||Histocompatibility Antigens Class I
|9.||Tissue Plasminogen Activator (Alteplase)
|10.||Interleukin-12 (IL 12)
|1.||Hormone Replacement Therapy (Therapy, Hormone Replacement)
|2.||Transplantation (Transplant Recipients)
|5.||Heterologous Transplantation (Xenotransplantation)