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Brachial Plexus Neuritis (Parsonage Turner Syndrome)

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A syndrome associated with inflammation of the BRACHIAL PLEXUS. Clinical features include severe pain in the shoulder region which may be accompanied by MUSCLE WEAKNESS and loss of sensation in the upper extremity. This condition may be associated with VIRUS DISEASES; IMMUNIZATION; SURGERY; heroin use (see HEROIN DEPENDENCE); and other conditions. The term brachial neuralgia generally refers to pain associated with brachial plexus injury. (From Adams et al., Principles of Neurology, 6th ed, pp1355-6)

Also Known As:

Parsonage Turner Syndrome; Brachial Neuralgia; Brachial Neuritis; Cervicobrachial Neuralgia; Parsonage-Aldren-Turner Syndrome; Amyotrophic Neuralgia; Amyotrophic Neuralgias; Amyotrophies, Neuralgic; Brachial Neuralgias; Brachial Neuritides; Brachial Plexus Neuritides; Cervico Brachial Neuralgia; Cervico-Brachial Neuralgias; Cervicobrachial Neuralgias; Neuralgia, Brachial; Neuralgia, Cervico-Brachial; Neuralgia, Cervicobrachial; Neuralgias, Amyotrophic; Neuralgias, Brachial; Neuralgias, Cervico-Brachial; Neuralgias, Cervicobrachial; Neuralgic Amyotrophies; Neuritides, Brachial; Neuritides, Brachial Plexus; Neuritis, Brachial; Neuropathies, Shoulder-Girdle; Neuropathy, Shoulder-Girdle; Parsonage Aldren Turner Syndrome; Shoulder Girdle Neuropathy; Shoulder-Girdle Neuropathies; Syndrome, Parsonage-Aldren-Turner; Syndrome, Parsonage-Turner; Amyotrophy, Neuralgic; Cervico-Brachial Neuralgia; Neuralgia, Amyotrophic; Neuralgic Amyotrophy; Neuritis, Brachial Plexus; Parsonage-Turner Syndrome; Shoulder-Girdle Neuropathy

Networked: 67 relevant articles (4 outcomes, 3 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3635
- Neuromuscular Diseases: 759
  - Peripheral Nervous System Diseases: 3424
    - Neuritis: 639
      - Brachial Plexus Neuritis: 67
    - Brachial Plexus Neuropathies: 111
      - Brachial Plexus Neuritis: 67

Related Diseases

1.	Wounds and Injuries (Trauma)
2.	Paralysis (Palsy)
3.	Pain (Aches)
4.	Brachial Plexus Neuritis (Parsonage Turner Syndrome)
5.	Tetanus

Experts

1.	van Engelen, B G M: 1 article (10/2009)
2.	van Eijk, J J J: 1 article (10/2009)
3.	van der Wilt, G J: 1 article (10/2009)
4.	van Alfen, N: 1 article (10/2009)
5.	Pillen, S: 1 article (10/2009)
6.	Berrevoets, M: 1 article (10/2009)
7.	Quader, Suzanne: 1 article (12/2008)
8.	Fathallah, Waseem: 1 article (12/2008)
9.	Al Masri, Omar: 1 article (12/2008)
10.	Errando, C L: 1 article (10/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Brachial Plexus Neuritis:

1.	Prednisolone (Predate)FDA LinkGeneric 10/01/2009 - "CONCLUSION: Oral prednisolone seems effective in the acute phase of neuralgic amyotrophy with the current results supporting previous case reports. " 10/01/2009 - "Evaluation of prednisolone treatment in the acute phase of neuralgic amyotrophy: an observational study." Order ALL the reference details at left...
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/1999 - "Epidural injections of corticosteroids in the cervical spine can provide effective treatment of cervicobrachial neuralgia. " 01/01/1995 - "[Chronic cervico-brachial neuralgia treated by cervical epidural injection of corticosteroids. " 09/01/1961 - "[Cervical epidural injections of corticoids in hyperalgic cervico-brachial neuralgias. " Order ALL the reference details at left...
3.	Metrizamide FDA Link 01/01/1985 - "Cervicobrachial neuralgias can now be easily evaluated by computerized tomography of the cervical spine due to recent technical progress (improved resolution, ultra-thin cuts, precise localization by computed radiography), and especially the use of intravenous contrast material, thus avoiding intrathecal metrizamide. " Order ALL the reference details at left...
4.	Genetic Markers (Genetic Marker)IBA 10/01/1996 - "Genetic linkage studies with polymerase chain reaction-based DNA markers in two large pedigrees recently localized the hereditary neuralgic amyotrophy gene to the distal long arm of chromosome 17 (17q24-qter)." Order ALL the reference details at left...
5.	EnzymesIBA 06/01/1970 - "Paralytic brachial neuritis with muscle enzymes and EMG studies. " Order ALL the reference details at left...
6.	ToxoidsIBA 05/25/1994 - "The committee found that the evidence favored acceptance of a causal relation between diphtheria and tetanus toxoids and Guillain-Barré syndrome and brachial neuritis, between measles vaccine and anaphylaxis, between oral polio vaccine and Guillain-Barré syndrome, and between unconjugated Hib vaccine and susceptibility to Hib disease. " 09/06/1996 - "Major changes to the previous recommendations are highlighted within the text, and specific information concerning the following vaccines and the possible adverse events associated with their administration are included: hepatitis B vaccine and anaphylaxis, measles vaccine and a) thrombocytopenia and b) possible risk for death resulting from anaphylaxis or disseminated disease in immunocompromised persons; diphtheria and tetanus toxoids and pertussis vaccine (DTP) and chronic encephalopathy; and tetanus-toxoid-containing vaccines and a) Guillain-Barre syndrome, b) brachial neuritis, and c) possible risk for death resulting from anaphylaxis. " Order ALL the reference details at left...
7.	Tetanus Toxoid (Vaccine, Tetanus)IBA 03/01/1984 - "Neuralgic amyotrophy after administration of tetanus toxoid." 09/06/1996 - "Major changes to the previous recommendations are highlighted within the text, and specific information concerning the following vaccines and the possible adverse events associated with their administration are included: hepatitis B vaccine and anaphylaxis, measles vaccine and a) thrombocytopenia and b) possible risk for death resulting from anaphylaxis or disseminated disease in immunocompromised persons; diphtheria and tetanus toxoids and pertussis vaccine (DTP) and chronic encephalopathy; and tetanus-toxoid-containing vaccines and a) Guillain-Barre syndrome, b) brachial neuritis, and c) possible risk for death resulting from anaphylaxis. " Order ALL the reference details at left...
8.	Measles VaccineIBA 05/25/1994 - "The committee found that the evidence favored acceptance of a causal relation between diphtheria and tetanus toxoids and Guillain-Barré syndrome and brachial neuritis, between measles vaccine and anaphylaxis, between oral polio vaccine and Guillain-Barré syndrome, and between unconjugated Hib vaccine and susceptibility to Hib disease. " 09/06/1996 - "Major changes to the previous recommendations are highlighted within the text, and specific information concerning the following vaccines and the possible adverse events associated with their administration are included: hepatitis B vaccine and anaphylaxis, measles vaccine and a) thrombocytopenia and b) possible risk for death resulting from anaphylaxis or disseminated disease in immunocompromised persons; diphtheria and tetanus toxoids and pertussis vaccine (DTP) and chronic encephalopathy; and tetanus-toxoid-containing vaccines and a) Guillain-Barre syndrome, b) brachial neuritis, and c) possible risk for death resulting from anaphylaxis. " Order ALL the reference details at left...
9.	InterferonsIBA 04/01/1988 - "Bilateral neuralgic amyotrophy induced by interferon treatment." 01/05/1985 - "Neuralgic amyotrophy and polyradiculopathy during interferon therapy." 04/01/1988 - "We describe a patient with hairy cell leukemia who developed bilateral neuralgic amyotrophy, sacral radicular irritation, and worsening of a preexistent polyneuropathy during treatment with recombinant interferon. " Order ALL the reference details at left...
10.	Contrast MediaIBA 06/15/1985 - "Neuralgic amyotrophy: a complication of neuroradiological contrast media." 03/01/1984 - "[Computed x-ray tomographic evaluation of cervico-brachial neuralgia with intravenous injection of contrast media]" Order ALL the reference details at left...

Therapies and Procedures

1.	Epidural Injections 03/01/2008 - "PURPOSE: Prospective study evaluating the efficacy and tolerability of CT guided cervical epidural injections for mechanical cervicobrachial neuralgia. " 03/01/2008 - "[Evaluation of CT guided cervical epidural injections in patients with mechanical cervicobrachial neuralgia]" 02/01/1999 - "[Cervical epidural injection technic under computed tomography guidance in the treatment of cervicobrachial neuralgia]" 02/01/1999 - "Epidural injections of corticosteroids in the cervical spine can provide effective treatment of cervicobrachial neuralgia. " 01/01/1995 - "[Chronic cervico-brachial neuralgia treated by cervical epidural injection of corticosteroids. " Order ALL the reference details at left...
2.	Transplants (Transplant) 01/01/1978 - "An anterior cervical approach completed by a bone graft is performed on a man suffering from cervico brachial neuralgia which did not improve by medical treatment and rest. " 01/01/1979 - "Cervicobrachial neuralgia of discal origin can be improved by a simple operation: excision of the pathological disc followed by an intercorporeal arthrodesis by the anterior approach, using an implanted graft without the use of any osteosynthetic material. " Order ALL the reference details at left...
3.	Arthrodesis 01/01/1979 - "[Arthrodesis of the cervical vertebrae by the anterior approach for the treatment of cervicobrachial neuralgias of discal origin (author's transl)]" 04/01/1974 - "[The treatment of cervico-brachial neuralgia by anterior arthrodesis]" 01/01/1979 - "Cervicobrachial neuralgia of discal origin can be improved by a simple operation: excision of the pathological disc followed by an intercorporeal arthrodesis by the anterior approach, using an implanted graft without the use of any osteosynthetic material. " Order ALL the reference details at left...
4.	Surgical Decompression 06/01/2007 - "There were excellent results after surgical decompression in the patients with a compression neuropathy, whereas the results after surgical decompression in the subgroup presenting with brachial plexus neuritis were less predictable. " 02/01/1993 - "It is concluded that non-traumatic anterior interosseous nerve lesions are most likely to reflect a circumscribed form of brachial neuritis and that surgical decompression should be deferred for at least a year or indefinitely if recovery is proceeding." 05/01/1997 - "Cases of brachial plexus neuritis-induced anterior interosseus nerve palsy should be managed conservatively, while surgical decompression may be performed for specific instances of direct trauma." Order ALL the reference details at left...
5.	Traction 06/01/1963 - "INTERMITTENT CERVICAL TRACTION IN CERVICOBRACHIAL NEURALGIA." 07/01/1955 - "[Cervicobrachial neuralgia treatment of spinal traction; cure.]" 01/01/2007 - "BACKGROUND: Long thoracic nerve injury leading to scapular winging is common, often caused by closed trauma through compression, stretching, traction, direct extrinsic force, penetrating injury, or neuritides such as Parsonage-Turner syndrome. " Order ALL the reference details at left...

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