Atrophic Muscular Disorders

159  relevant articles (2 outcomes, 24 trials/studies) found for this Disease

Muscular Disorders, Atrophic; Spinobulbar Atrophy; Spinopontine Atrophy; Atrophic Muscular Disorder; Atrophies, Disuse; Atrophies, Spinobulbar; Atrophies, Spinobulbar Muscular; Atrophies, Spinopontine; Atrophy, Spinobulbar; Atrophy, Spinobulbar Muscular; Disorder, Atrophic Muscular; Disorders, Atrophic Muscular; Disuse Atrophies; Disuse Atrophy; Muscular Atrophies, Spinobulbar; Muscular Disorder, Atrophic; Spinobulbar Atrophies; Spinobulbar Muscular Atrophies; Spinopontine Atrophies; Atrophy, Disuse; Atrophy, Muscular, Spinobulbar; Atrophy, Spinopontine; Muscular Atrophy, Spinobulbar; Spinobulbar Muscular Atrophy

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Muscular Dystrophies (Muscular Dystrophy)
2.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
3.	Spinocerebellar Ataxias (Spinocerebellar Ataxia)
4.	Neuromuscular Diseases (Neuromuscular Disease)
5.	Hypokinesia (Bradykinesia)

Experts

1.	Beitel, L K: 2 articles (01/2005 - 10/2001)
2.	Trifiro, M A: 2 articles (01/2005 - 10/2001)
3.	Gottlieb, B: 2 articles (01/2005 - 10/2001)
4.	Leo, Francesco: 1 article (07/2008)
5.	Ayas, Najib: 1 article (07/2008)
6.	Heunks, Leo M A: 1 article (07/2008)
7.	Needham, Dale M: 1 article (07/2008)
8.	Fan, Eddy: 1 article (07/2008)
9.	McCool, Dennis: 1 article (07/2008)
10.	Dekhuijzen, Richard P N: 1 article (07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Atrophic Muscular Disorders:

1.	NF-kappa B (NF-kB)IBA 12/01/2005 - "Therefore, using NF-kappaB pathway inhibitors may prove beneficial in attenuating NF-kappaB-associated muscle damage in both disuse atrophy and strenuous exercise." 10/01/2009 - "Therefore, the purpose of the current study was to determine whether electrotransfer of Hsp27 into the soleus muscle of rats, prior to skeletal muscle disuse, is sufficient to inhibit skeletal muscle disuse atrophy and NF-kappaB activation. " 10/01/2009 - "In conclusion, Hsp27 is a negative regulator of NF-kappaB in skeletal muscle, in vivo, and is sufficient to inhibit MuRF1 and atrogin-1 and attenuate skeletal muscle disuse atrophy." 01/01/2007 - "NF-kappaB seems to be a key intracellular signal transducer in disuse atrophy. " 04/01/2002 - "Thus, whereas several NF-kappaB family members are up-regulated, the prototypical markers of cytokine-induced activation of NF-kappaB seen with disease-related wasting are not evident during disuse atrophy. " Order ALL the reference details at left...
2.	CreatineIBA 10/15/2001 - "Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans." 02/01/2006 - "Recent studies have suggested that creatine can be beneficial in patients with muscular dystrophy and other mitochondrial cytopathies, and may attenuate sarcopenia and facilitate rehabilitation of disuse atrophy. " 09/01/2009 - "PURPOSE: Creatine (Cr) supplementation may improve muscle functional capacity in patients with neuromuscular diseases, disuse atrophy, or muscular dystrophies. " Order ALL the reference details at left...
3.	polyglutamineIBA 02/02/2007 - "In polyglutamine diseases such as X-linked spinobulbar muscular atrophy (SBMA), it is unknown whether the toxic form of the protein is an insoluble or soluble aggregate or a monomer. " 06/05/2003 - "Two recently published papers on spinocerebellar ataxia type 1, together with studies on spinobulbar muscular atrophy last year, indicate that host protein context is the key arbiter of polyglutamine disease protein toxicity. " 08/01/2006 - "To date, nine distinct genes are known to be linked to polyglutamine diseases, including Huntington's disease, Machado-Joseph Disease and spinobulbar muscular atrophy or Kennedy's disease. " 03/14/2000 - "Huntington's disease (HD), spinocerebellar ataxias types 1 and 3 (SCA1, SCA3), and spinobulbar muscular atrophy (SBMA) are caused by CAG/polyglutamine expansion mutations. " 11/01/2003 - "To date, nine polyglutamine disorders have been characterised, including Huntington's disease (HD), spinobulbar muscular atrophy (SBMA), dentatorubral-pallidoluysian atrophy (DRPLA), and spinocerebellar ataxias 1, 2, 3, 6, 7 and 17 (SCAs). " Order ALL the reference details at left...
4.	Androgen Receptors (Androgen Receptor)IBA 02/02/2007 - "Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy." 04/01/2003 - "We show that mutant androgen receptor (AR), the protein responsible for X-linked spinobulbar muscular atrophy, forms insoluble aggregates and is toxic to cultured cells. " 01/01/2003 - "Although the CAG repeat in the androgen receptor, associated with spinobulbar muscular atrophy, was the first to be published in 1991, it was the publication in the same year of the molecular basis of fragile X that focused much attention on trinucleotide repeat expansion as a mutational mechanism. " 01/01/2000 - "In the present study using anti-1-hexitol-lysine (1-HL) antibody, Amadori product, an early glycation product, was detected in axonal spheroids in the anterior horn of amyotrophic lateral sclerosis and in atrophic neurons of spinobulbar muscular atrophy (SBMA, Kennedy disease with abnormally expanded triplet repeats in androgen receptor gene) but not in other regions of the central nervous system. " 01/01/2004 - "Kennedy's disease (spinobulbar muscular atrophy) is an X-linked form of motor neuron disease affecting adult males carrying a CAG trinucleotide repeat expansion within the androgen receptor gene. " Order ALL the reference details at left...
5.	Polymethyl Methacrylate (Sol)IBA 05/01/1983 - "The soleus (SOL) and extensor digitorum longus (EDL) muscles of the rat were studied in situ (33.5 degrees C) after 6 wk of disuse atrophy produced by hindlimb immobilization (IM). " 06/01/1985 - "Because immobilization of muscles in the "long" position mitigates the effects of inactivity and rapid wasting occurs when muscles are immobilized in the "short" position, a study was made of the EMG activity in the soleus (SOL)--an extensor muscle--and the tibialis anterior (TA)--a flexor muscle--in order to clarify the possible role of muscle function in modifying the course of disuse atrophy. " 02/01/1997 - "The purposes of the study were to determine the effects of a pyrimidine nucleotide, the uridine triphosphate (UTP), on the contractile and histochemical properties of the soleus (SOL) muscle following disuse atrophy due to hindlimb unloading (HU) hypokinesia. " Order ALL the reference details at left...
6.	FlexorIBA 03/01/2006 - "Additional studies suggested that the recruitment order reversal in the 2-week chronic animals coincided with an enhanced reflex neural output (increased recruitment or reflex gain) for the flexion reflex which compensated for disuse atrophy related decreases in flexor muscle force generation capability in these animals. " 06/01/1985 - "Because immobilization of muscles in the "long" position mitigates the effects of inactivity and rapid wasting occurs when muscles are immobilized in the "short" position, a study was made of the EMG activity in the soleus (SOL)--an extensor muscle--and the tibialis anterior (TA)--a flexor muscle--in order to clarify the possible role of muscle function in modifying the course of disuse atrophy. " Order ALL the reference details at left...
7.	Muscle Proteins (Muscle Protein)IBA 01/01/2008 - "Therefore, the present study addressed the hypothesis that EtOH accelerates the disuse atrophy and/or impairs the accretion of muscle protein during muscle recovery. " 12/01/1985 - "Changes in muscle protein composition induced by disuse atrophy: analysis by two-dimensional electrophoresis." 01/01/2008 - "CONCLUSIONS: Based on the changes in these surrogate markers, our data suggest that EtOH accelerates disuse atrophy by stimulating ubiquitin-mediated proteolysis, and blunts repletion of muscle protein during recovery from disuse by increasing proteolysis and decreasing protein synthesis." 01/01/2007 - "Factors such as myostatin, p38 and calcineurin can induce muscle protein loss under specified conditions, but further experiments are needed to determine whether they are necessary components of disuse atrophy. " 07/01/1991 - "The results suggest that the net breakdown of carbonic anhydrase III and myoglobin during disuse atrophy occur at the same rate as the average net degradation of mixed muscle proteins and that the process is independent of the immobilization procedure." Order ALL the reference details at left...
8.	Estrogens (Estrogen)FDA Link 12/01/2001 - "Our previous studies demonstrated that estrogen (E2) prevents the development of disuse atrophy of the femur in tail-suspended rats. " 06/01/2006 - "These results suggest that myofiber growth, myofiber regeneration, and extracellular matrix remodeling are estrogen-sensitive components of soleus muscle mass recovery from disuse atrophy." 06/01/2006 - "Estrogen status and skeletal muscle recovery from disuse atrophy." 12/01/1997 - "Effect of estrogen on the development of disuse atrophy of bone and muscle induced by tail-supension in rats." 12/01/1997 - "In the present investigation we studied how ovariectomy and estrogen substitution affect the development of the disuse atrophy induced by suspension. " Order ALL the reference details at left...
9.	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 02/01/1986 - "Previous studies using suspended rats demonstrated that muscle disuse atrophy resulting from hindlimb unloading was associated with an increase in glucocorticoid receptor site concentration. " 11/01/1980 - "Disuse atrophy of skeletal muscle is associated with an increase in number of glucocorticoid receptors." 10/01/1987 - "Disuse atrophy, plasma corticosterone, and muscle glucocorticoid receptor levels." Order ALL the reference details at left...
10.	Metalloproteases (Metalloproteinases)IBA 01/01/2003 - "Our study demonstrated that metalloproteinases are expressed relatively late after limb immobilization and appear to be responsible to a large degree for degradation of the extracellular matrix in experimental disuse atrophy." 02/01/1995 - "Cartilage metalloproteases in disuse atrophy." Order ALL the reference details at left...

Therapies and Procedures

1.	Denervation 11/01/1999 - "Muscle fiber conduction velocity in situ (MFCV) in denervation, reinnervation and disuse atrophy." 06/01/1968 - "Denervation and disuse atrophy in pigeon breast muscle. " 09/01/1962 - "Denervation and disuse atrophy in crosstriated muscle." 07/01/2009 - "Causes of disuse atrophy include loss of upper motor neurons, which occurs in spinal cord injury (SCI) or lower motor neurons (denervation). " 01/01/1958 - "Disuse atrophy produces no changes in electrical activity, whereas denervation atrophy manifests itself by typical denervation activity. " Order ALL the reference details at left...
2.	Artificial Respiration (Mechanical Ventilation) 07/03/2008 - "Mechanical ventilation and disuse atrophy of the diaphragm." 07/03/2008 - "Mechanical ventilation and disuse atrophy of the diaphragm." 07/03/2008 - "Mechanical ventilation and disuse atrophy of the diaphragm." 07/03/2008 - "Mechanical ventilation and disuse atrophy of the diaphragm." 07/03/2008 - "Mechanical ventilation and disuse atrophy of the diaphragm." Order ALL the reference details at left...
3.	Bed Rest (Bedrest) 12/01/2002 - "Hypercreatine kinasemia normalized during complete bed-rest in patients with X-linked spinobulbar muscular atrophy." 05/01/2002 - "Disuse atrophy of muscle begins within 4 hours of the start of bed rest resulting in decreases in muscle mass, muscle cell diameter, and the number of muscle fibers. " 01/01/1975 - "Many of these changes persisted on day 6 after bed rest, and are interpreted as concomitants of the disuse atrophy of the musculoskeletal system that characterizes prolonged bed rest and weightlessness." 03/01/1979 - "It is concluded that both atrophy and degeneration of fibres of proximal muscles can occur as non-specific consequences of disuse of the limb in man, that degeneration is a latter and more severe change, that muscles even of the non-immobilized leg are subjected to disuse atrophy during bed-rest, and that the proximal muscles in man seem to have a natural susceptibility to atrophy and degeneration in any muscular disorders." Order ALL the reference details at left...
4.	Resistance Training 06/01/2005 - "This is important because the strength training goals and precautions differ in disuse atrophy and a neuropathy. " 01/01/2005 - "BACKGROUND: Strength training or aerobic exercise programmes might maximise muscle and cardiorespiratory function and prevent additional disuse atrophy in patients with muscle disease. " Order ALL the reference details at left...
5.	Enteral Nutrition (Feeding, Tube) 09/01/1998 - "Total parenteral nutrition (TPN) is associated with an increased incidence of bacterial translocation (BT) compared with enteral nutrition because of the disuse atrophy of the intestine. " 12/01/2005 - "Because leg muscles represent approximately one quarter of the normal body weight, low weight-for-height values among children with CP can be caused by leg muscle wasting attributable to disuse atrophy, which is unlikely to be correctable with tube feeding. " Order ALL the reference details at left...