Embryo Loss

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87 relevant articles (5 outcomes, 7 trials/studies) found for this Disease

Description: Early pregnancy loss during the EMBRYO, MAMMALIAN stage of development. In the human, this period comprises the second through eighth week after fertilization.

Also Known As:

Disintegration of Blastocyst; Disintegration of Embryo; Death, Embryo; Disintegration, Blastocyst; Embryo Deaths; Resorption, Embryo; Blastocyst Disintegration; Embryo Death; Embryo Disintegration; Embryo Resorption

Relationship Network

Disease Context: Research Results

Female Urogenital Diseases and Pregnancy Complications

Pregnancy Complications: 515

Spontaneous Abortion: 3354

Embryo Loss: 87

Signs and Symptoms Pathological Conditions

Pathologic Processes: 2210

Death: 1110

Embryo Loss: 87

Related Diseases

1.	Aneuploidy (Aneuploid)
2.	Hemorrhage
3.	Body Weight (Weight, Body)
4.	Spontaneous Abortion (Miscarriage)
5.	Poisoning

Experts

1.	Zeng, Shan: 2 articles (04/2006 - 10/2005)
2.	Zeng, Yaoying: 2 articles (04/2006 - 10/2005)
3.	Lin, Yi: 2 articles (04/2006 - 10/2005)
4.	Aoki, Fugaku: 1 article (05/2006)
5.	Akiyama, Tomohiko: 1 article (05/2006)
6.	Nagata, Masao: 1 article (05/2006)
7.	Dai, Li-Jun: 1 article (04/2006)
8.	Liu, Han-Ying: 1 article (04/2006)
9.	Yang, Zeng-Ming: 1 article (04/2006)
10.	Lu, Jia-Chun: 1 article (04/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Embryo Loss:

1.	AntigensIBA 05/01/2002 - "METHODS: The mouse models of spontaneous abortion CBA/J x DBA/2 were established, then we administrated the models by oral proper dosage antigens ovum albumin (OVA), trophoblast menbrane antigens trophoblast membrane antigen (TMA)1, TMA2 and observed the changes of embryo loss rate (ELR) as compared with the control groups: group without immunization, group of active immunization by injecting intraperitoneally spleenocytes and blank control by feeding normal saline (NS)" 06/01/2005 - "Our findings suggest that paternal antigen-tolerant T cells transferred in recipient not only function as antigen-specific suppresser cells but also disable the recipient reactive T cells, which co-suppresses maternal rejection to the allogeneic fetus, thus resulting in the decrease of the embryo resorption rate of the abortion-prone mice to that of the normal pregnancy mice." 04/01/2004 - "RESULTS: In the CBA/J x DBA/2 matings, anti-CD(80), CD(86) mAb administered at day 4 of gestation reduced significantly the embryo resorption rate, and induced a significantly lower proliferation response and IL-2 production by maternal splenic immuno-competent cells to paternal antigen compared with rat isotype IgG. CONCLUSIONS: In vivo blockade of costimulatory signal at day 4 of gestation can induce the immuno-tolerance of maternal peripheral immuno-competent cells to paternal antigen, thus leading the embryo resorption rate of the abortion-prone model to that of normal pregnancy model." 01/01/1996 - "However, due to the short half-life of IgM antibodies, immunity to LPS was short-lived and the protective effect of LPS immunization against LPS induced abortion waned after 5 wk. Through the use of the CBA/J female x DBA/2 male model system to study spontaneous early embryo loss, previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freund's adjuvant (CFA) or LPS, all decreased the incidence of spontaneous resorption in subsequent pregnancies" Order ALL the reference details at left...
2.	AntibodiesIBA 10/01/1998 - "In the APS murine models presented here, both the Lupus-prone mice and the naive mice with induced APS, fetal resorption (parallels to embryo loss) and reduced fecundity rate were prominent features strongly associated with pathogenic aCL antibodies, making these models appropriate for investigating the human disease" 01/01/1996 - "However, due to the short half-life of IgM antibodies, immunity to LPS was short-lived and the protective effect of LPS immunization against LPS induced abortion waned after 5 wk. Through the use of the CBA/J female x DBA/2 male model system to study spontaneous early embryo loss, previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freund's adjuvant (CFA) or LPS, all decreased the incidence of spontaneous resorption in subsequent pregnancies" 06/15/2003 - "The 2 upper levels of IgG and IgM anti-protein Z antibodies were associated with the risk of unexplained recurrent embryo loss or fetal death independently from habitual antiphospholipid/anticofactor antibodies, and a dose-effect relationship between antibody levels and the clinical risks was evidenced" Order ALL the reference details at left...
3.	Immunoglobulin M (IgM)IBA 01/01/1996 - "However, due to the short half-life of IgM antibodies, immunity to LPS was short-lived and the protective effect of LPS immunization against LPS induced abortion waned after 5 wk. Through the use of the CBA/J female x DBA/2 male model system to study spontaneous early embryo loss, previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freund's adjuvant (CFA) or LPS, all decreased the incidence of spontaneous resorption in subsequent pregnancies" 06/15/2003 - "The 2 upper levels of IgG and IgM anti-protein Z antibodies were associated with the risk of unexplained recurrent embryo loss or fetal death independently from habitual antiphospholipid/anticofactor antibodies, and a dose-effect relationship between antibody levels and the clinical risks was evidenced" Order ALL the reference details at left...
4.	Freund's AdjuvantIBA 01/01/1996 - "However, due to the short half-life of IgM antibodies, immunity to LPS was short-lived and the protective effect of LPS immunization against LPS induced abortion waned after 5 wk. Through the use of the CBA/J female x DBA/2 male model system to study spontaneous early embryo loss, previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freund's adjuvant (CFA) or LPS, all decreased the incidence of spontaneous resorption in subsequent pregnancies" Order ALL the reference details at left...
5.	Acrolein (Aqualin)IBA 06/15/1987 - "The EC50 values for embryo deaths and malformations were decreased to 50 and 20%, respectively, of those values for acrolein alone" 06/15/1987 - "Acrolein alone produced a 25 and 48% incidence of embryo deaths at 50 and 100 microM, respectively, and a 46% incidence of embryo malformations, as well as significant growth retardation, among the surviving embryos at 100 microM" 07/01/1987 - "However, a 6-hr preincubation with 500 microM glutathione, prior to exposure to acrolein (in the absence of exogenous glutathione), significantly decreased the incidence of embryo deaths at 160 microM acrolein and brought the number of deaths and malformations among embryos exposed to 120 microM acrolein down to a level not significantly different from control; unlike the embryos exposed concurrently to acrolein and glutathione, however, the sequential treatment with glutathione and acrolein did not protect against growth retardation" 07/01/1987 - "Day 10 rat embryos were cultured in the presence of acrolein and glutathione, either concurrently or sequentially, and evaluated for embryo deaths, malformations, growth retardation, and content of glutathione and protein" 06/15/1987 - "The addition of 10 microM buthionine sulfoximine resulted in 100% embryolethality at 100 microM acrolein; this buthionine sulfoximine concentration decreased the EC50 values for embryo deaths and malformations to 50% of those for acrolein alone" Order ALL the reference details at left...
6.	Prostaglandins D (PGD)IBA 09/01/1999 - "Two conclusions were obtained: (i) PGD of aneuploidy reduced embryo loss after implantation; (ii) implantation rates were not significantly improved, but the proportion of ongoing and delivered babies was increased." Order ALL the reference details at left...
7.	Glutathione (Reduced Glutathione)IBA 07/01/1987 - "However, a 6-hr preincubation with 500 microM glutathione, prior to exposure to acrolein (in the absence of exogenous glutathione), significantly decreased the incidence of embryo deaths at 160 microM acrolein and brought the number of deaths and malformations among embryos exposed to 120 microM acrolein down to a level not significantly different from control; unlike the embryos exposed concurrently to acrolein and glutathione, however, the sequential treatment with glutathione and acrolein did not protect against growth retardation" 07/01/1987 - "Day 10 rat embryos were cultured in the presence of acrolein and glutathione, either concurrently or sequentially, and evaluated for embryo deaths, malformations, growth retardation, and content of glutathione and protein" Order ALL the reference details at left...
8.	lactate dehydrogenase C4IBA 09/01/1994 - "Systemic immunization with LDH-C4 did not reduce the overall pregnancy rate but reduced the frequency of embryo resorption and increased litter size significantly" Order ALL the reference details at left...
9.	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/01/1995 - "In this study, the role of nitric oxide (NO) in the mechanism of early embryo loss was studied" 01/01/2000 - "In this report, we examined whether nitric oxide (NO) is involved in early embryo death" 05/15/1997 - "We have previously shown that increased nitric oxide production by decidual macrophages is involved in early embryo loss occurring at day 12 of gestation" 10/01/1995 - "Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells." 05/01/1996 - "On the other hand, far fewer of the CBA/J x Balb/c conceptuses (5-10% embryo loss) displayed significant cellular infiltration and nitric oxide and TNF alpha" Order ALL the reference details at left...
10.	Progesterone FDA LinkGeneric 04/01/2008 - "This study highlights the use of serum progesterone in combination with ultrasound for the investigation of embryo loss and crucial times during development of normal and SCNT embryos in sheep" 12/01/2006 - "It appears that high producing dairy cows have an increased risk of embryo death as a result of lowered peripheral concentrations of progesterone as a consequence of increased hepatic metabolism of progesterone" 07/01/2006 - "The level of nutrition and peripheral progesterone concentrations are inversely related, and increased rates of embryo loss, associated with higher progesterone concentrations in ewes with low levels of nutrition have been reported" 04/15/2006 - "Overall, the results indicate that suboptimal progesterone support during the early luteal phase is likely to deleteriously affect embryo viability and in addition, that it is possible to predict milk progesterone concentrations during the early luteal phase based on earlier stage concentrations and thus identify cows at risk of early embryo loss." 04/15/1996 - "Embryo loss, based on concentrations of progesterone at Day 18 post insemination, was 43, 19 and 18% in the BG, NG and PG group, respectively" Order ALL the reference details at left...

Therapies and Procedures

1.	Induced Abortion (Induced Abortions) 01/01/1996 - "However, due to the short half-life of IgM antibodies, immunity to LPS was short-lived and the protective effect of LPS immunization against LPS induced abortion waned after 5 wk. Through the use of the CBA/J female x DBA/2 male model system to study spontaneous early embryo loss, previous vaccination of CBA/J female mice with Balb/c spleen cells expressing paternal MHC antigens, complete Freund's adjuvant (CFA) or LPS, all decreased the incidence of spontaneous resorption in subsequent pregnancies" Order ALL the reference details at left...
2.	Curettage 09/01/1992 - "The spontaneous and previous embryo death induce a scanty bleeding following curettage and thus, corroborate in a natural way the efficacy of any substance used to desvitalize the pregnancy and in consequence, diminish the vascular blood flow before evacuation in order to get a good result following conservative management." Order ALL the reference details at left...
3.	Homologous Transplantation (Allograft) 10/01/1995 - "In early embryo loss, the fetus may be considered to be an allograft and, therefore, may be rejected by maternal immunocytes" Order ALL the reference details at left...
4.	Ovariectomy (Oophorectomy) 01/01/1991 - "Oestrogen given alone after ovariectomy increased embryo loss, but restored preimplantation embryo development to normal when given on Day 3 after progestins on Day 1. The results suggested that both oestrogen and progesterone were necessary for normal preimplantation embryo development in vivo" Order ALL the reference details at left...
5.	Aftercare (After-Treatment) 01/01/1992 - "A possible reason for the variability in conception rates is the high incidence of complete embryo loss or fertilization failure in ewes that are induced to superovulate after treatment with the doses of PMSG required to promote a high oestrous response" Order ALL the reference details at left...

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