Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)

GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with members of the seven transmembrane domain superfamily of G-PROTEIN-COUPLED RECEPTORS. Upon activation the GTP-BINDING PROTEIN ALPHA SUBUNIT of the complex dissociates leaving a dimer of a GTP-BINDING PROTEIN BETA SUBUNIT bound to a GTP-BINDING PROTEIN GAMMA SUBUNIT.

Also Known As:

Heterotrimeric G-Proteins; G Protein, Heterotrimeric; G-Protein, Heterotrimeric; G-Proteins, Heterotrimeric; GTP-Binding Protein, Heterotrimeric; GTP-Binding Proteins, Heterotrimeric; Heterotrimeric G Proteins; Heterotrimeric GTP Binding Protein; Heterotrimeric GTP Binding Proteins; Protein, Heterotrimeric G; Protein, Heterotrimeric GTP-Binding; Heterotrimeric G Protein; Heterotrimeric G-Protein; Heterotrimeric GTP-Binding Protein

Networked: 265 relevant articles (0 outcomes, 18 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Casey, Patrick J: 6 articles (01/2014 - 05/2006)
2.	Gutkind, J Silvio: 5 articles (12/2020 - 11/2007)
3.	Koch, Walter J: 5 articles (01/2017 - 09/2003)
4.	Birnbaumer, Lutz: 4 articles (10/2018 - 08/2009)
5.	Fujisawa, Yukiko: 4 articles (04/2012 - 10/2002)
6.	Iwasaki, Yukimoto: 4 articles (04/2012 - 10/2002)
7.	Bruyneel, Erik: 4 articles (09/2006 - 06/2002)
8.	Gespach, Christian: 4 articles (09/2006 - 06/2002)
9.	Jiang, Ya-Ping: 3 articles (04/2017 - 10/2006)
10.	Lin, Richard Z: 3 articles (04/2017 - 10/2006)

Related Diseases

1.	Neoplasms (Cancer) 10/30/2014 - "In this study, we demonstrated that expression of the heterotrimeric G-protein alpha-12 (Gα12) is highly up-regulated in primary tumors and LN of OSCC patients, as assessed by quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC). " 01/01/2014 - "Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12 signaling and cancer progression. " 07/11/1997 - "This is the first study to implicate a heterotrimeric G protein in tumor suppression." 01/01/2023 - "The heterotrimeric G protein Gα13 is highly expressed in various cancers and regulates diverse cancer-related transcriptional networks and cellular functions by activating Rho. " 01/01/2023 - "Gα13, a heterotrimeric G protein α subunit of the G12/13 subfamily, is an oncogenic driver in multiple cancer types. "
2.	Whooping Cough (Pertussis) 10/01/2000 - "Both cholera and pertussis toxins were used to label and study the expression of heterotrimeric G protein alpha subunits in Plasmodium falciparum extracts. " 04/30/2000 - "Both cholera and pertussis toxins were used to label and study the expression of heterotrimeric G protein alpha subunits in Plasmodium falciparum extracts. " 04/01/1997 - "Because adenosine 3',5'-cyclic monophosphate (cAMP) and heterotrimeric G proteins may alter ion transporters, I tested whether cholera and pertussis toxins affected acidification of rat liver endosomes. " 12/01/1994 - "ADP-ribosylation of heterotrimeric G proteins by cholera and pertussis toxins decreased the Luk-PV-induced LTB4-generation. " 07/30/2002 - "GDP/GTP exchange assay data and studies with pertussis (PTX) toxin suggest that mastoparan may work directly to activate Cdc42 and not via PTX-sensitive heterotrimeric GTP-binding proteins. "
3.	Carcinogenesis 01/01/2012 - "PMT modifies and activates members of three of the four families of heterotrimeric G-proteins, all of which have potential roles in carcinogenesis. " 06/09/2011 - "Heterotrimeric G proteins are molecular switches that control signal transduction, and their dysregulation can promote oncogenesis. " 01/01/2011 - "The G12 subfamily of the heterotrimeric G proteins, Galpha12 and Galpha13, has been implicated as an important signaling component in various cellular processes including oncogenesis and cells invasion. " 01/16/2001 - "The G12 subfamily of heterotrimeric G proteins, comprised of the alpha-subunits Galpha12 and Galpha13, has been implicated as a signaling component in cellular processes ranging from cytoskeletal changes to cell growth and oncogenesis. " 09/08/2006 - "Many studies have suggested a role for the members of the G12 family of heterotrimeric G proteins (Galpha12 and Galpha13) in oncogenesis and tumor cell growth. "
4.	Heart Failure 06/23/2014 - "A mouse model of reversible heart failure that is driven by conditional activation of the heterotrimeric G protein Gαq in cardiac myocytes was used in this study. " 04/01/2017 - "Receptors that activate the heterotrimeric G protein Gαq are thought to play a role in the development of heart failure. " 10/16/2012 - "Our data show that the G(12/13) family of heterotrimeric G proteins is centrally involved in pressure overload-induced cardiac remodeling and plays a central role in the transition to heart failure." 01/01/2011 - "Roles of heterotrimeric GTP-binding proteins in the progression of heart failure." 05/01/2010 - "[Molecular mechanism underlying the development of heart failure mediated by heterotrimeric G protein signaling]."
5.	Cholera 10/01/2000 - "Both cholera and pertussis toxins were used to label and study the expression of heterotrimeric G protein alpha subunits in Plasmodium falciparum extracts. " 04/30/2000 - "Both cholera and pertussis toxins were used to label and study the expression of heterotrimeric G protein alpha subunits in Plasmodium falciparum extracts. " 04/01/1997 - "Because adenosine 3',5'-cyclic monophosphate (cAMP) and heterotrimeric G proteins may alter ion transporters, I tested whether cholera and pertussis toxins affected acidification of rat liver endosomes. " 12/01/1994 - "ADP-ribosylation of heterotrimeric G proteins by cholera and pertussis toxins decreased the Luk-PV-induced LTB4-generation. " 11/15/1992 - "Transducin (T alpha beta gamma), the heterotrimeric GTP-binding protein that interacts with photoexcited rhodopsin (Rh*) and the cGMP-phosphodiesterase (PDE) in retinal rod cells, is sensitive to cholera (CTx) and pertussis toxins (PTx), which catalyze the binding of an ADP-ribose to the alpha subunit at Arg174 and Cys347, respectively. "

Related Drugs and Biologics

1.	Guanosine Triphosphate (GTP)
2.	mastoparan
3.	beta-Adrenergic Receptor Kinases
4.	Catenins
5.	Guanosine Diphosphate (GDP)
6.	aluminum fluoride
7.	Proteins (Proteins, Gene)
8.	GTP-Binding Proteins (G-Protein)
9.	Carrier Proteins (Binding Protein)
10.	Guanine Nucleotides

Related Therapies and Procedures

1.	Therapeutics