Benign Neonatal Epilepsy (Benign Familial Neonatal Convulsions)

52  relevant articles (1 outcomes, 0 trials/studies) found for this Disease

Benign Familial Neonatal Convulsions; Epilepsy, Benign Neonatal; Benign Familial Neonatal Epilepsy; Benign Neonatal Epilepsy, Nonfamilial; Benign Neonatal Non-Familial Convulsions; Benign Neonatal Nonfamilial Epilepsy; Benign Non-Familial Neonatal Convulsions; Convulsions, Benign Neonatal, Familial; Convulsions, Benign Neonatal, Non-Familial; Epilepsy, Benign Neonatal, Familial; Epilepsy, Benign Neonatal, Non-Familial; Epilepsy, Benign Neonatal, Nonfamilial; Familial Benign Neonatal Convulsions; Familial Benign Neonatal Epilepsy; Non-Familial Benign Neonatal Convulsions; Non-Familial Benign Neonatal Epilepsy; Benign Neonatal Convulsion; Benign Neonatal Convulsions; Benign Neonatal Epilepsies; Benign Neonatal Non Familial Convulsions; Benign Non Familial Neonatal Convulsions; Convulsion, Benign Neonatal; Convulsions, Benign Neonatal; Epilepsies, Benign Neonatal; Neonatal Convulsion, Benign; Neonatal Epilepsies, Benign; Neonatal Epilepsy, Benign; Non Familial Benign Neonatal Convulsions; Non Familial Benign Neonatal Epilepsy; Neonatal Convulsions, Benign

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Epilepsy (Aura)
2.	Syndrome
3.	Frontal Lobe Epilepsy (Epilepsy, Supplementary Motor)
4.	Generalized Epilepsy
5.	Febrile Seizures (Febrile Seizure)

Experts

1.	Castaldo, Pasqualina: 3 articles (05/2007 - 01/2002)
2.	Taglialatela, Maurizio: 3 articles (05/2007 - 01/2002)
3.	Annunziato, Lucio: 3 articles (05/2007 - 01/2002)
4.	Pascotto, Antonio: 3 articles (05/2007 - 01/2002)
5.	Soldovieri, Maria Virginia: 2 articles (05/2007 - 01/2006)
6.	Bellini, Giulia: 2 articles (05/2007 - 01/2006)
7.	Miraglia del Giudice, Emanuele: 2 articles (05/2007 - 01/2006)
8.	Miceli, Francesco: 2 articles (05/2007 - 01/2006)
9.	Shapiro, Mark S: 1 article (05/2007)
10.	Cilio, Maria Roberta: 1 article (05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Benign Neonatal Epilepsy:

1.	Potassium Channels (Potassium Channel)IBA 05/02/2007 - "Atypical gating of M-type potassium channels conferred by mutations in uncharged residues in the S4 region of KCNQ2 causing benign familial neonatal convulsions." 10/15/2005 - "Potassium channel mutations cause benign familial neonatal convulsions" 09/01/2005 - "Potassium channel mutations cause benign familial neonatal convulsions" 01/15/2002 - "Benign familial neonatal convulsions caused by altered gating of KCNQ2/KCNQ3 potassium channels." 06/01/2000 - "At present, only one mutation of KCNQ3, a KCNQ potassium channel gene, has been identified as a cause of benign familial neonatal convulsions type 2 (BFNC2)" Order ALL the reference details at left...
2.	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 06/15/2004 - "Two voltage-gated potassium channel genes, KCNQ2 on chromosome 20q13.3 and KCNQ3 on chromosome 8q24, have been identified as the genes responsible for benign familial neonatal convulsions" 10/28/2002 - "Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions" 01/01/1999 - "Two highly homologous voltage-gated potassium channels, KCNQ2 and KCNQ3, were found to be mutated in benign familial neonatal convulsions." 06/26/2000 - "In 1998, mutations in the voltage gated potassium channel gene KCNQ2 were found to be the main cause underlying the autosomal dominant inherited syndrome of benign familial neonatal convulsions (BFNC)" 04/26/1999 - "Mutations in the voltage gated potassium channel gene KCNQ2 and the homologous gene KCNQ3 have been found to cause a rare monogenic subtype of idiopathic generalized epilepsy, the benign familial neonatal convulsions" Order ALL the reference details at left...
3.	Ion Channels (Ion Channel)IBA 01/01/2005 - "Genetic analyses of familial epilepsies over the past decade have identified mutations in several different ion channel genes that result in neonatal or early-onset seizure disorders, including benign familial neonatal convulsions (BFNC), generalized epilepsy with febrile seizures plus (GEFS+), and severe myoclonic epilepsy of infancy (SMEI)" 06/01/2000 - "DEVELOPMENT: We studied the main ion channel disorders related to simply inherited idiopathic epileptic syndromes in which four genes have been codified to date: benign familial neonatal convulsions, generalized epilepsy with febrile seizures plus and autosomal dominant nocturnal frontal lobe epilepsy" 12/01/2006 - "Thus, the discovery of KCNQ2 mutations in benign familial neonatal convulsions, SCN1A mutations in severe myoclonic epilepsy of infancy and in generalized epilepsy with febrile seizures plus, and CHRA4 and CHRB2 mutations in autosomal-dominant nocturnal frontal lobe epilepsy, has led to the establishment of epilepsy as a disorder of ion channel function and, furthermore, has led to the introduction of genetic tests that are available clinically to aid in diagnosis and treatment" 06/01/2000 - "Two human epilepsy syndromes, benign familial neonatal convulsions and generalized epilepsy with febrile seizures plus, represent K+ and Na+ channelopathies, and other newly defined syndromes have now been mapped to chromosomal regions that are rich in ion channel genes" 12/01/2000 - "Recently, gene defects underlying four monogenic epilepsies (generalized epilepsy with febrile seizures, autosomal dominant nocturnal frontal lobe epilepsy, benign familial neonatal convulsions and episodic ataxia type 1 with partial seizures) have been identified, shedding new light on the pathophysiology of epilepsy as these diseases are caused by ion channel mutations" Order ALL the reference details at left...
4.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 07/01/1995 - "The gene coding for the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (CHRNA4) has been recently mapped in the candidate region for benign familial neonatal convulsions (BFNC) on chromosome 20q13.2-q13.3" 09/01/2002 - "Mutations in the neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunit genes have been detected in families with autosomal dominant nocturnal frontal lobe epilepsy, and those of two K(+) channel genes were identified to be responsible for underlying genetic abnormalities of benign familial neonatal convulsions" 03/01/1996 - "The human neuronal nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4) is located in the candidate region for three different phenotypes: benign familial neonatal convulsions, autosomal dominant nocturnal frontal lobe epilepsy, and low-voltage EEG" 05/20/2004 - "Mutations of the nicotinic acetylcholine receptor subunits are found in familial nocturnal frontal lobe epilepsy, while defects in the voltage gated potassium channels (KCNQ2 and KCNQ3) have been identified in benign familial neonatal convulsions" 01/01/2002 - "Mutations in the CHRNA4 or CHRNB subunits of the neuronal nicotinic acetylcholine receptor lead to familial nocturnal frontal lobe epilepsy, while defects in the voltage-gated potassium channels KCNQ2 and KCNQ3 have recently been found to cause benign familial neonatal convulsions" Order ALL the reference details at left...
5.	KCNQ3 Potassium ChannelIBA 05/01/2007 - "Human mutations of KCNQ2 and KCNQ3 potassium channel genes result in reduction or loss of channel activity and cause benign familial neonatal convulsions (BFNCs)" 12/01/2003 - "KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum." 12/17/1998 - "Potassium channels are important regulators of electrical signalling, and benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, is caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes" Order ALL the reference details at left...
6.	Glutamic Acid (Glutamate)FDA Link 11/10/2000 - "To explore the pathogenesis of benign familial neonatal convulsions (BFNC), we determined effects of KCNQ-related M-channels (KCNQ-channels) on hippocampal glutamate (Glu) and gamma-aminobutyric acid (GABA) releases using microdialysis, and propagation of evoked field-potentials (FP) using multielectrode (64-ch)-dish system as two-dimensional monitoring" 02/15/1996 - "A glutamate binding subunit gene, GRINA, has been previously mapped to human chromosome 8. A form of inherited epilepsy, benign familial neonatal convulsions (BFNC), has also been localized to chromosome 8. As NMDA receptors have been implicated in the pathogenesis of epilepsy, we were interested in determining whether GRINA mapped to the same region of chromosome 8 as BFNC" Order ALL the reference details at left...
7.	Sodium Channels (Sodium Channel)IBA 01/01/1999 - "In humans, three autosomal-dominant disorders--benign familial neonatal convulsions, nocturnal frontal lobe epilepsy, and "generalized epilepsy with febrile seizures plus"--result from mutations affecting voltage-sensitive potassium channels, a central nicotinic acetylcholine receptor, and a voltage-sensitive sodium channel, respectively" 01/01/2001 - "Consequently, mutations in ion channel encoding genes are found in a variety of inherited diseases associated with hyper- or hypoexcitability of the affected tissue, the so-called 'channelopathies.' An increasing number of epileptic syndromes belongs to this group of rare disorders: Autosomal dominant nocturnal frontal lobe epilepsy is caused by mutations in a neuronal nicotinic acetylcholine receptor (affected genes: CHRNA4, CHRNB2), benign familial neonatal convulsions by mutations in potassium channels constituting the M-current (KCNQ2, KCNQ3), generalized epilepsy with febrile seizures plus by mutations in subunits of the voltage-gated sodium channel or the GABA(A) receptor (SCN1B, SCN1A, GABRG2), and episodic ataxia type 1-which is associated with epilepsy in a few patients--by mutations within another voltage-gated potassium channel (KCNA1)" Order ALL the reference details at left...
8.	PotassiumIBA 01/06/2006 - "Decreased subunit stability as a novel mechanism for potassium current impairment by a KCNQ2 C terminus mutation causing benign familial neonatal convulsions." 12/01/2000 - "Neuronal potassium channelopathies can cause familial benign neonatal convulsions and episodic ataxia type 1. Finally, neuronal calcium channelopathies can cause episodic ataxia type 2, familial hemiplegic migraine and spinocerebellar ataxia type 6. CONCLUSION: The clinical features, aetiology and pathogenesis of inherited voltage-gated ion channel disorders affecting muscle and the central nervous system are reviewed here." Order ALL the reference details at left...
9.	KCNQ2 Potassium ChannelIBA 04/01/2004 - "Complete loss of the cytoplasmic carboxyl terminus of the KCNQ2 potassium channel: a novel mutation in a large Czech pedigree with benign neonatal convulsions or other epileptic phenotypes." Order ALL the reference details at left...
10.	Type 3 Melanocortin ReceptorIBA 08/01/1994 - "The data reported here also show that the neural MC3 receptor maps close to a disease locus for benign neonatal epilepsy in human and near the E1-2 epilepsy susceptibility locus in the mouse." Order ALL the reference details at left...