Mitogen-Activated Protein Kinases

A superfamily of PROTEIN SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).

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Networked: 7508 relevant articles (145 outcomes, 685 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Wei: 19 articles (01/2022 - 11/2004)
2.	Zhang, Xin: 18 articles (01/2022 - 02/2004)
3.	Wang, Wei: 16 articles (01/2021 - 02/2003)
4.	Li, Li: 16 articles (04/2020 - 06/2007)
5.	Armstead, William M: 16 articles (01/2019 - 07/2002)
6.	Li, Jing: 15 articles (07/2022 - 11/2002)
7.	Gaestel, Matthias: 15 articles (12/2021 - 05/2002)
8.	Wang, Xin: 15 articles (01/2021 - 07/2003)
9.	Flaherty, Keith T: 14 articles (01/2019 - 05/2006)
10.	Herlyn, Meenhard: 14 articles (07/2016 - 01/2002)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 08/09/2020 - "Although the development of mitogen-activated protein kinase (MAPK) inhibitors has greatly improved the prognosis of BRAFV600 cutaneous melanomas, the identification of molecular indicators for mutated patients at risk of early progression remains a major issue. " 04/03/2019 - "Recently developed targeted treatment directed against mutant BRAF and downstream mitogen-activated protein kinase (MAPK) MAP2K1 (also termed MEK1) have improved overall survival of melanoma patients. " 11/01/2018 - "The treatment of advanced BRAFV600-mutated melanomas with BRAF inhibitors (BRAFi) has improved survival, but the efficacy of BRAFi varies among individuals and the development of acquired resistance to BRAFi through reactivation of mitogen-activated protein kinase (MAPK) signaling is common. " 01/01/2018 - "Mitogen-activated protein kinase (MAPK) pathway inhibitors show promise in treating melanoma, but are unsuccessful in achieving long-term remission. " 10/01/2016 - "Inhibitors of the mitogen-activated protein kinase (MAPK) signal pathway have decisively improved the prognosis of metastatic cutaneous melanoma in patients with an activating mutation in position V600 of the BRAF gene. "
2.	Neoplasms (Cancer) 08/20/2022 - "In this study, we determine that DU-4475 is a mono-driver cancer cell line relying on BRAF and the mitogen-activated protein kinase pathway for viability and proliferation. " 01/01/2022 - "In this review, we will first describe the function of GSTP1 and then extend the details onto its role in the mitogen-activated protein kinase signal pathway, referring to the results of our recent study that proposed a novel autocrine signal loop formed by the CRAF/GSTP1 complex in mutated KRAS and BRAF cancers. " 08/01/2020 - "In this sense, the mitogen-activated protein kinase (MAPK) signaling pathway has become an important aim of the studies in several cancers. " 01/01/2020 - "Here, we review recent efforts to validate individual components of the mitogen-activated protein kinase (MAPK) pathway as targets to treat KRAS-mutant cancers by comparing genetic information derived from experimental mouse models of KRAS-driven lung and pancreatic tumors with the outcome of selective MAPK inhibitors in clinical trials. " 01/01/2018 - "To demonstrate the applicability of the proposed control scheme, we conduct simulation studies using a regulation influence network describing the metastatic process of cells and the Mitogen-activated protein kinase (MAPK) signaling network that is crucial in cancer cell fate determination."
3.	Inflammation (Inflammations) 04/01/2018 - "Therefore, the results of the current study demonstrate that NMP inhibits inflammation dependent on the mitogen-activated protein kinase pathway in MG-63 cells, indicating that it may be beneficial in the healing of fractures." 07/01/2012 - "The aim of the current study was to examine whether these protective effects were due to attenuation of mitogen activated protein kinase (MAPK) signaling pathways, which are known to promote inflammation and apoptosis. " 11/01/2020 - "The protective effects of ISL against inflammation and oxidative stress were mediated by the inhibition of mitogen-activated protein kinases (MAPKs) and induction of nuclear factor-erythroid 2 related factor 2 (Nrf2) signaling pathway, respectively. " 11/15/2023 - "CP ameliorates inflammation by upregulating mitogen-activated protein kinase phosphatase-1 (MKP-1) and thereby decreasing the phosphorylation levels of P38 and JNK. " 12/02/2023 - "During the last two decades, many p38α mitogen-activated protein kinase (p38α MAPK) inhibitors have been developed and tested in preclinical/clinical studies for the treatment of various disorders, especially problems with the origin of inflammation. "
4.	Fibrosis (Cirrhosis) 03/04/2019 - "Further study revealed that the effect of Sal on renal interstitial fibrosis is associated with the lower expression of TLR4, p-IκBα, p-NF-κB and mitogen-activated protein kinases (MAPK), both in vivo and in vitro. " 12/15/2016 - "Much of our understanding of how mitogen-activated protein kinases (MAPK) signaling promotes renal fibrosis has been based on cell culture studies. " 12/01/2023 - "The mitogen-activated protein kinase (MAPK) signaling may exacerbate renal fibrosis. " 04/01/2021 - "Renal fibrosis with the activation of Smad3 and mitogen-activated protein kinase (MAPK) pathways were also inhibited by PAA treatment. " 01/01/2021 - "Here we show that the mitogen-activated protein kinase (MAPK) phosphatase-5 (MKP-5) in macrophages is involved in pressure overload-induced cardiac fibrosis. "
5.	Sarcoma (Soft Tissue Sarcoma) 12/01/2021 - "The identification of activating somatic mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) gene and other mitogen-activated protein kinase (MAPK) pathway genes has opened up new avenues for bAVM study, leading to a paradigm shift to search for somatic, de novo mutations in sporadic bAVMs instead of focusing on inherited genetic mutations. " 01/01/2023 - "Phosphoproteomic analysis demonstrated hyperphosphorylation of the rat sarcoma-mitogen-activated protein kinase system suggesting activation of this signaling cascade. " 12/01/2022 - "They are caused by somatic pathogenic variants of the genes belonging the RAt Sarcoma Mitogen-activated protein kinase (RAS/MAPK) pathway causing its hyperactivation. " 04/23/2021 - "RASopathies represent a family of mostly autosomal dominant diseases that are caused by missense variants in the rat sarcoma viral oncogene/mitogen activated protein kinase (RAS/MAPK) pathway including KRAS, NRAS, BRAF, RAF1, and SHP2. " 01/01/2021 - "The KEGG analysis results show that the differentially expressed genes are primarily involved in specific pathways, including the rat sarcoma signaling pathway and the mitogen-activated protein kinase (MAPK) signaling pathway. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Mitogen-Activated Protein Kinase Kinases (MEKs)
3.	Proteins (Proteins, Gene)
4.	NF-kappa B (NF-kB)
5.	Ligands
6.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	trametinib
9.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Electroacupuncture
4.	Immunotherapy
5.	Ligation