Dexmedetomidine

An imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely related to MEDETOMIDINE, which is the racemic form of this compound.

Also Known As:

Dexmedetomidine Hydrochloride; MPV-1440; Precedex; Hydrochloride, Dexmedetomidine; MPV 1440; MPV1440; Cepedex; Dexdomitor; Dexdor; Igalmi; Sedadex; Sileo; 1H-Imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, (R)-

Networked: 4316 relevant articles (594 outcomes, 1117 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Dexmedetomidine: 4316

Experts

1.	Tobias, Joseph D: 40 articles (11/2019 - 04/2003)
2.	Zhang, Wei: 20 articles (12/2022 - 03/2012)
3.	Ma, Daqing: 18 articles (01/2022 - 10/2004)
4.	Shehabi, Yahya: 17 articles (01/2022 - 12/2004)
5.	Maze, Mervyn: 15 articles (01/2022 - 09/2004)
6.	Peng, Ke: 15 articles (01/2022 - 11/2014)
7.	Kamali, Alireza: 14 articles (07/2022 - 09/2018)
8.	Bellomo, Rinaldo: 14 articles (02/2022 - 01/2009)
9.	Li, Jun: 14 articles (01/2022 - 05/2014)
10.	Devlin, John W: 13 articles (01/2022 - 09/2012)

Related Diseases

1.	Pain (Aches) 04/01/2024 - "The results showed statistically significant intergroup differences in pain scores and average pain intensity in the dexmedetomidine group was significantly lower than the other groups. " 07/01/2020 - "As dexmedetomidine mediates central nervous system sympathetic activity and pain modulation, its intraoperative use could be beneficial in craniofacial surgery. " 07/01/2019 - "The results showed that the injection of dexmedetomidine in epidural caudal was associated with decreased pain (p=0.001) and improved quality of life (p=0.022), while showed no significant effect on ESR (p=0.110). " 01/01/2019 - "Compared with placebo group, patients in dexmedetomidine group reported significant lower numerical rating score pain scores at 3, 12, 24, and 48 hrs after surgery (all P<0.05) and significant improved Richards Campbell Sleep Questionnaire results during the first 3 postoperative days (all P<0.0001). " 09/01/2008 - "Dexmedetomidine administration resulted in a significant reduction in pain scores for 6 h after operation in the intra-articular group but only for 1 h in the i.v. group. "
2.	Postoperative Pain 01/01/2023 - "As a result, we designed this study to determine if adding dexmedetomidine to an erector spinae plane block (ESPB) that is guided by ultrasound (US) is beneficial for treating immediate postoperative pain following shoulder arthroscopy. " 12/01/2021 - "Compared with the NS group, dexmedetomidine-soaked nasal packing significantly relieved postoperative pain and improved sleep quality. " 01/01/2017 - "However, it remains unclear whether peripheral administration of dexmedetomidine is safe and effective to reduce acute postoperative pain. " 06/13/2022 - "Efficacy of dexmedetomidine on postoperative pain in patients undergoing gastric and esophageal endoscopic submucosal dissection: a study protocol for a randomized controlled prospective trial." 06/01/2016 - "Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies."
3.	Emergence Delirium 01/01/2020 - "The 2 meta-analyses found that all included studies had a statistically significant reduction in postoperative delirium when using dexmedetomidine. " 01/01/2019 - "Pre-operative administration of dexmedetomidine demonstrated several significant benefits, such as a lower incidence of emergence agitation, reduced agitation severity, and a shorter duration of agitation. " 12/01/2019 - "We performed this updated meta-analysis to ascertain more precisely the efficacy of dexmedetomidine (DEX) on the incidence of postoperative delirium (POD) in elderly patients after non-cardiac surgery. " 01/01/2019 - "The purpose of this trial was to evaluate whether pre-operative administration of dexmedetomidine is effective in reducing the incidence and severity of emergence agitation in adults undergoing closed reduction of nasal bone fractures. " 01/01/2023 - "Automated phenotyping of postoperative delirium-like behaviour in mice reveals the therapeutic efficacy of dexmedetomidine."
4.	Delirium 06/04/2018 - "Only few studies have compared the efficacy of dexmedetomidine in non-intubated ICU patients as a first-line curative treatment of delirium. " 01/01/2022 - "A high-dose continuous infusion of IV dexmedetomidine was administered, and his violent behavior and delirium significantly improved. " 01/01/2019 - "Pooled analysis showed a significant reduction in delirium incidence for dexmedetomidine treatment, and bispectral index (BIS)-guided anaesthesia. " 04/12/2016 - "Among the 21 a priori secondary outcomes, none were significantly worse with dexmedetomidine, and several showed statistically significant benefit, including reduced time to extubation (median, 21.9 hours vs 44.3 hours with placebo; median difference between groups, 19.5 hours [95% CI, 5.3 to 31.1 hours]; P < .001) and accelerated resolution of delirium (median, 23.3 hours vs 40.0 hours; median difference between groups, 16.0 hours [95% CI, 3.0 to 28.0 hours]; P = .01). " 02/01/2015 - "In the dexmedetomidine group, delirium rating scale was significantly smaller than that of the control group (P<0.05) while Ramsay sedation score was significantly greater than that of the control group (P<0.05). "
5.	Reperfusion Injury 12/01/2019 - "Dexmedetomidine (Dex) has been proven to exert protective effects on multiple organs in response to ischaemia-reperfusion injury, but the specific mechanism by which this occurs has not been fully elucidated. " 05/01/2021 - "To investigate protective effects of dexmedetomidine on small intestinal ischaemia-reperfusion injury in the horse. " 05/01/2021 - "Protective effects of dexmedetomidine on small intestinal ischaemia-reperfusion injury in horses." 01/01/2021 - "The Protective Effects of Dexmedetomidine Preconditioning on Hepatic Ischemia/Reperfusion Injury in Rats." 07/01/2017 - "Protective effects of dexmedetomidine and remote ischemic preconditioning on renal ischemia reperfusion injury in rats."

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4.	Hypnotics and Sedatives (Sedatives)
5.	Fentanyl (Sublimaze)
6.	Ropivacaine (Naropin)
7.	Ketamine
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Related Therapies and Procedures

1.	Analgesia
2.	Anesthesia
3.	Artificial Respiration (Mechanical Ventilation)
4.	Therapeutics
5.	Length of Stay