Medetomidine

07/13/2020 - "We noted a generally early high contrast enhancement of the CVC under medetomidine sedation, likely contributed by the induced bradycardia. "
01/01/2017 - "However, medetomidine is known to cause peripheral vasoconstriction, respiratory suppression, and bradycardia, each of which could independently confound the BOLD signal. "
05/01/2010 - "Medetomidine CRI produces clinically relevant changes in CO, TPR, and HR. The demonstrated decrease in CO is largely because of bradycardia and the degree of cardiovascular depression appears to be dose-dependent. "
10/01/2003 - "Bradycardia and bradypnoea were the consistent findings after medetomidine injection. "
02/01/1993 - "After medetomidine administration, marked bradycardia developed in all dogs and persisted for more than 2 hours. "

01/01/2008 - "Respiratory depression and bradycardia typically for medetomidine were seen in all three combinations, but quickly reversed after partial antagonisation. "
07/01/2010 - "Medetomidine induced significant respiratory depression with decrease in RR and TV in freely moving animals while cocaine increased TV, RR and minute ventilation (MV) with concomitant increase in heart rate when compared with time matched values from saline-treated animals. "
05/24/1997 - "The combination of medetomidine with fentanyl was unsuitable for obtaining surgical anaesthesia in spontaneously breathing animals owing to the severity of the respiratory depression at dosages needed for general anaesthesia."
01/01/1989 - "The slope of the CO2 response curve was significantly steeper after medetomidine (0.582 vs 0.269 1.min-1.mmHg), suggesting less respiratory depression when compared to the measurements under isoflurane. "
06/01/1993 - "The side effects of medetomidine were bradycardia, respiratory depression, stasis of the rumen with tympany, salivation and polyuria. "

06/01/2021 - "Profound hypothermia developed and esophageal temperature, measured 20 minutes after medetomidine injection, was 33 °C. "
01/01/1989 - "Hypothermia has been reported in every animal sedated with medetomidine. "
09/01/1996 - "Other actions that follow medetomidine use are slowing of gastrointestinal motility, hypothermia, changes to endocrine function and, occasionally, vomiting and muscle twitching. "
11/01/2000 - "Xylazine and medetomidine induced significant (p<0.05) decrease in heart rate, respiratory rate and hypothermia. "
11/01/2003 - "Other physiological effects of medetomidine sedation include; vomiting, increased urine volumes, changes to endocrine function and uterine activity, decreased intestinal motility, decreased intraocular pressure and potentially hypothermia, muscle twitching, and cyanosis. "

09/19/1997 - "Subcutaneous (s.c.) injection of medetomidine at 0.05, 0.1 and 0.3 mg/kg, 15 min before diazinon (75 mg/kg, orally) significantly and dose-dependently decreased the incidence of toxic manifestations, delayed the onset of tremors and death, and increased the 24 h survival rates to 70, 80 and 100%, respectively. "
01/01/2022 - "Clinical adverse effects such as tremors (facial and generalized), bruxism, nystagmus, mydriasis, and vocalization were presented in all the medetomidine/opioid treatments. "

01/01/2013 - "The mixture of 0.3 mg/kg body weight (b.w.) medetomidine (Med.), 4.0 mg/kg b.w. "
10/01/2012 - "The treatment groups were: CONTROL = saline bolus followed by saline CRI; MED1 = 2 μg/kg body weight (BW) medetomidine loading dose followed by 1 μg/kg BW per hour CRI; and MED2 = 4 μg/kg BW medetomidine loading dose followed by 2 μg/kg BW per hour CRI. "
01/01/2012 - "In ovo exposure of the chicks to medetomidine at 25 and 50 μg/egg did not significantly affect the body weight of the chicks as well as their morphometric measurements. "
12/01/2002 - "Medetomidine was injected by the intramuscular route at the rates of 3 and 5 microg/kg body weight into two groups of Indian elephants (Elephas maximus). "
11/01/2001 - "Baseline variables were recorded, and medetomidine (20 microg/kg of body weight, IM) was administered. "