Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain)

A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.

Also Known As:

Hypoxia Ischemia, Brain; Hypoxia-Ischemia, Brain; Encephalopathy, Anoxic-Ischemic; Encephalopathy, Hypoxic-Ischemic; Anoxia Ischemia, Brain; Anoxia Ischemia, Cerebral; Anoxia-Ischemias, Brain; Anoxia-Ischemias, Cerebral; Anoxic Ischemic Encephalopathy; Anoxic-Ischemic Encephalopathies; Brain Anoxia Ischemia; Brain Anoxia-Ischemias; Brain Hypoxia Ischemia; Brain Hypoxia-Ischemias; Brain Ischemia Anoxia; Brain Ischemia Hypoxia; Brain Ischemia-Anoxias; Brain Ischemia-Hypoxias; Cerebral Anoxia Ischemia; Cerebral Anoxia-Ischemias; Cerebral Hypoxia Ischemia; Cerebral Hypoxia-Ischemias; Cerebral Ischemia Anoxia; Cerebral Ischemia Hypoxia; Cerebral Ischemia-Anoxias; Cerebral Ischemia-Hypoxias; Encephalopathies, Anoxic-Ischemic; Encephalopathies, Hypoxic-Ischemic; Encephalopathies, Ischemic-Hypoxic; Encephalopathy, Anoxic Ischemic; Encephalopathy, Hypoxic Ischemic; Encephalopathy, Ischemic-Hypoxic; Hypoxia Ischemia, Cerebral; Hypoxia-Ischemias, Brain; Hypoxia-Ischemias, Cerebral; Hypoxic Ischemic Encephalopathy; Hypoxic-Ischemic Encephalopathies; Ischemia Anoxia, Brain; Ischemia Anoxia, Cerebral; Ischemia Hypoxia, Brain; Ischemia Hypoxia, Cerebral; Ischemia-Anoxias, Brain; Ischemia-Anoxias, Cerebral; Ischemia-Hypoxias, Brain; Ischemia-Hypoxias, Cerebral; Ischemic Hypoxic Encephalopathy; Ischemic-Hypoxic Encephalopathies; Anoxia-Ischemia, Brain; Anoxia-Ischemia, Cerebral; Anoxic-Ischemic Encephalopathy; Brain Anoxia-Ischemia; Brain Ischemia-Anoxia; Brain Ischemia-Hypoxia; Cerebral Anoxia-Ischemia; Cerebral Hypoxia-Ischemia; Cerebral Ischemia-Anoxia; Cerebral Ischemia-Hypoxia; Hypoxia-Ischemia, Cerebral; Hypoxic-Ischemic Encephalopathy; Ischemia-Anoxia, Brain; Ischemia-Anoxia, Cerebral; Ischemia-Hypoxia, Brain; Ischemia-Hypoxia, Cerebral; Ischemic-Hypoxic Encephalopathy

Networked: 1998 relevant articles (102 outcomes, 285 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypothermia
2.	Heart Arrest (Cardiac Arrest)
3.	Brain Injuries (Brain Injury)
4.	Infections
5.	Stroke (Strokes)

Experts

1.	Shankaran, Seetha: 21 articles (11/2022 - 08/2003)
2.	Massaro, An N: 21 articles (01/2022 - 03/2013)
3.	Laptook, Abbot R: 19 articles (11/2022 - 10/2002)
4.	Chang, Taeun: 19 articles (01/2022 - 04/2012)
5.	Bennet, Laura: 18 articles (06/2022 - 01/2015)
6.	Gunn, Alistair J: 18 articles (06/2022 - 01/2015)
7.	Glass, Hannah C: 16 articles (01/2022 - 03/2011)
8.	Van Meurs, Krisa P: 15 articles (11/2022 - 03/2014)
9.	Groenendaal, Floris: 15 articles (01/2022 - 04/2004)
10.	Juul, Sandra E: 14 articles (01/2022 - 04/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Brain Hypoxia-Ischemia:

1.	Erythropoietin FDA Link 06/18/2021 - "Multiple clinical trials have demonstrated the safety and efficacy of erythropoietin in improving neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy (HIE). " 10/01/2014 - "Phase II and III clinical trials are currently in process to determine the safety and efficacy of neuroprotective dosing of erythropoietin for extreme prematurity and hypoxic-ischemic encephalopathy in neonates." 06/18/2021 - "Efficacy of erythropoietin alone in treatment of neonates with hypoxic-ischemic encephalopathy: A protocol for systematic review and meta-analysis." 08/01/2009 - "Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy." 01/01/2022 - "Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns."
2.	Oxygen (Dioxygen)IBA 12/25/2017 - "Application of "Xingnao Kaiqiao" acupuncture combined with hyperbaric oxygen in patients with hypoxic ischemic encephalopathy can result in an integrated curative effect, a significant improvement in the blood rheology indexes, and promote the recovery of brain cells." 01/01/2016 - "Hyperbaric oxygen preconditioning ameliorates hypoxia-ischemia brain damage by activating Nrf2 expression in vivo and in vitro." 01/01/2016 - "The present study aimed to investigate whether hyperbaric oxygen preconditioning (HBO-PC) could ameliorate hypoxia-ischemia brain damage (HIBD) by an increase of Nrf2 expression. " 08/01/2005 - "The aim of the study was to determine whether neonates resuscitated with room air compared with 100 per cent oxygen in the delivery room were less likely to have hypoxic ischemic encephalopathy and/or death before discharge. " 10/20/2023 - "Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage in newborns due to insufficient blood and oxygen supply during or after birth. "
3.	Biomarkers (Surrogate Marker)IBA 12/22/2016 - "The aim of the present paper is to review present knowledge about the pathophysiology of perinatal hypoxic-ischemic encephalopathy, especially with respect to novel treatment strategies and biomarkers that might enhance early detection of this disorder and thus improve the general outcome of patients." 01/01/2022 - "This study aimed to evaluate the role of an objective physiologic biomarker, arterial blood pressure variability, for the early identification of adverse short-term electroencephalogram (EEG) outcomes in infants with hypoxic-ischemic encephalopathy (HIE). " 12/01/2021 - "The goal of the study is to compare the predictive performance of these four biomarkers for the combined primary outcome of hypoxic-ischemic encephalopathy/death. " 06/25/2021 - "In our opinion, it is difficult to identify reliable and confirmed biomarkers from multiple studies in order to support a postmortem diagnosis of acute cerebral hypoxia/ischemia. " 12/01/2020 - "The aim of the presented study was to evaluate the differences between selected biochemical markers in infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) and their impact on patient prognosis. "
4.	MelatoninIBA 01/01/2020 - "In the present study, the salivary melatonin secretion in the hypoxic ischemic encephalopathy (HIE) children was measured. " 03/01/2015 - "The objective of this study is to examine the effect of melatonin on clinical, biochemical, neurophysiological and radiological outcomes of neonates with hypoxic-ischemic encephalopathy (HIE). " 03/01/2009 - "The present study was conducted to evaluate the formation of oxidative damage mediators and the possible effect of melatonin treatment in a model of hypoxic-ischemic encephalopathy in 7-day-old rats. " 01/22/2023 - "In recent years, it has been pointed out that natural compounds with neuroprotective properties, such as melatonin, can be used in the treatment of hypoxic-ischemic encephalopathy. " 01/01/2022 - "Melatonin Administration from 2000 to 2020 to Human Newborns with Hypoxic-Ischemic Encephalopathy."
5.	Phenobarbital (Luminal)FDA Link 11/09/2021 - "They are often caused by hypoxic-ischemic encephalopathy and are frequently refractory to the first-line antiseizure medication phenobarbital. " 01/01/2021 - "He developed a convulsive attack, diagnosed as a grade 2 hypoxic-ischemic encephalopathy, which was controlled by phenobarbital. " 08/01/2010 - "Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy." 06/01/2010 - "Four of the patients in whom there was no increase in serum phenobarbital levels had hypoxic-ischemic encephalopathy. " 12/01/2005 - "Asphyxiated neonates (gestational age >or= 34 weeks) manifesting with hypoxic ischemic encephalopathy (HIE) in the first six hours of life were randomized to receive either injection of phenobarbital 20 mg/kg IV or to the control group. "
6.	Phosphopyruvate Hydratase (Enolase)IBA 03/01/2009 - "To examine electroencephalographic (EEG) background patterns and serum neuron specific enolase (NSE) levels in neonates with hypoxic-ischemic encephalopathy (HIE) in order to study their roles in assessing clinical progress, severity and prognosis in children with HIE. " 09/01/2004 - "The aim of this study was to evaluate serum concentrations of neuron-specific enolase (NSE) as a marker of the severity of hypoxic ischemic encephalopathy (HIE) and to elucidate the relation among the concentrations of NSE, grade of HIE and short-term outcome. " 09/25/2023 - "We evaluated the correlation between quantitative background activities on electroencephalography (EEG) and serum neuron specific enolase (NSE) in patients with hypoxic-ischemic encephalopathy as well as a diagnostic value of prognostication. " 01/01/2022 - "Serum neuron-specific enolase, magnetic resonance imaging, and electrophysiology for predicting neurodevelopmental outcomes of neonates with hypoxic-ischemic encephalopathy: a prospective study." 01/01/2022 - "The current standard of care for assessing neurological status in patients with hypoxic-ischemic encephalopathy emphasizes a multimodal approach that includes five elements: (1) neurological examination off sedation, (2) continuous electroencephalography, (3) serum neuron-specific enolase levels, (4) magnetic resonance brain imaging, and (5) somatosensory-evoked potential testing. "
7.	Topiramate (Topamax)FDA LinkGeneric 01/01/2019 - "Topiramate plus Cooling for Hypoxic-Ischemic Encephalopathy: A Randomized, Controlled, Multicenter, Double-Blinded Trial." 04/01/2020 - "Topiramate for hypoxic ischemic encephalopathy: A systematic review protocol." 04/01/2018 - "Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI): a feasibility study." 09/05/2012 - "Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)." 04/01/2018 - "To investigate the feasibility of a study based on treatment with topiramate (TPM) added to moderate hypothermia in newborns with hypoxic ischemic encephalopathy (HIE). "
8.	scutellarinIBA 01/01/2020 - "A series of novel scutellarin methyl ester-4'-dipeptide conjugates exhibiting active transport characteristics and protection against pathological damage caused by hypoxic-ischemic encephalopathy (HIE) were successfully designed and synthesized. " 10/18/2021 - "Scutellarin ameliorates neonatal hypoxic-ischemic encephalopathy associated with GAP43-dependent signaling pathway." 01/01/2023 - "Scutellarin attenuates microglia activation in experimentally induced hypoxia-ischemia brain damage by down-regulating miRNA-7036a." 01/01/2020 - "Synthesis, pharmacological evaluation and mechanistic study of scutellarin methyl ester -4'-dipeptide conjugates for the treatment of hypoxic-ischemic encephalopathy (HIE) in rat pups." 01/01/2022 - "Scutellarin protects cortical neurons against neonatal hypoxic-ischemic encephalopathy injury via upregulation of vascular endothelial growth factor."
9.	Peptides (Polypeptides)IBA 01/01/2019 - "Pilose antler polypeptides (PAP) have recently been found to be effective in the treatment of brain damage in hypoxic-ischemic encephalopathy (HIE). " 01/01/2021 - "Peptidomic Analysis of Neonate Umbilical Cord Blood for the Identification of Endogenous Peptides Involved in Hypoxic-Ischemic Encephalopathy." 04/02/2015 - "Therefore, Cdk5 inhibition by the small peptide p5-TAT or its derivatives is a promising therapeutic strategy for the treatment of ischemic brain injury including hypoxic-ischemic encephalopathy and stroke. " 03/01/2018 - "Pilose antler polypeptides ameliorates hypoxic-ischemic encephalopathy by activated neurotrophic factors and SDF1/CXCR4 axis in rats." 07/01/2010 - "PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia."
10.	TNF Receptor-Associated Factor 6 (TRAF6)IBA 01/01/2023 - "Circ_0007706 downregulation ameliorates neonatal hypoxic ischemic encephalopathy via regulating the miR-579-3p/TRAF6 axis." 08/01/2020 - "Overexpression of miR-146b-5p Ameliorates Neonatal Hypoxic Ischemic Encephalopathy by Inhibiting IRAK1/TRAF6/TAK1/NF-αB Signaling."

Therapies and Procedures

1.	Induced Hypothermia 06/11/2022 - "Therapeutic hypothermia significantly improves outcomes after moderate-severe hypoxic-ischemic encephalopathy (HIE), but it is partially effective. " 03/01/2022 - "What is Known: • Therapeutic hypothermia is beneficial in neonatal hypoxic-ischemic encephalopathy. " 12/01/2018 - "With the addition of therapeutic hypothermia into the treatment regimen for neonatal hypoxic ischemic encephalopathy, newborns afflicted with hypoxic ischemic encephalopathy were given the opportunity for a better outcome. " 01/30/2024 - "Although therapeutic hypothermia is currently considered an effective treatment for neonatal hypoxic-ischemic encephalopathy (HIE), neonatal HIE is a disease requiring multiple therapeutic measures. " 12/01/2022 - "Therapeutic hypothermia (TH) is effective for neonatal hypoxic-ischemic encephalopathy (HIE). "
2.	Therapeutics 05/18/2021 - "Identifying an effective method for the early diagnosis of neonatal hypoxic-ischemic encephalopathy (HIE) would be beneficial for effective therapies. " 11/01/1981 - "Thus, in experiments examining "cerebral protective effects" of therapies during brain hypoxia-ischemia, stringent control of body temperature is necessary. " 03/19/2021 - "Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies." 10/01/2017 - "Future studies aimed at uncovering the mechanisms of NMNAT3 upregulation and neuroprotection may offer new therapies against the effects of hypoxic-ischemic encephalopathy." 12/23/2015 - "Our study may form the basis for future clinical trials, which will evaluate whether MAPC therapy is capable of reducing neurological sequelae in preterm infants with hypoxic-ischemic encephalopathy."
3.	Ligation 09/01/2015 - "The hypoxia-ischemia brain injury models were made by ligature of the left common carotid artery and then inhalation of 8%O(2)/92%N(2) for 2 h. " 05/01/2014 - "The rats in the model and PROG groups underwent a left common carotid artery ligation and were placed in a sealed container at 37°C with 8% O2 and 92% N2 gas mixtures for 2.5 h to establish animal models of hypoxic-ischemic encephalopathy. " 01/01/2014 - "To establish the hypoxic-ischemic encephalopathy (HIE) model, the pups from the HI group were subjected to left common carotid artery ligation followed by exposure to 8% O2 and 92% N2. " 02/01/2013 - "To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL). " 02/01/1987 - "Cerebral hypoxia-ischemia was produced in 1-week-old rats by exposing them to 8% O2-92% N2 commencing 4 to 6 h after unilateral carotid artery ligation. "
4.	Resuscitation 01/01/2008 - "A trend toward a decrease in the risk of hypoxic ischemic encephalopathy stage 2 and 3 was noted with resuscitation in 21% O(2) in the analysis of all studies (typical RR 0.88, 95% CI 0.72, 1.08). " 11/01/2022 - "After resuscitation including artificial ventilation, stabilization of the condition was achieved against the background of the development of hypoxic-ischemic encephalopathy. " 05/01/2018 - "This injury at birth often requires a complex resuscitation and increases the newborn's risk of hypoxic-ischemic encephalopathy (HIE). " 01/01/2018 - "Although bispectral index (BIS) has been widely used for predicting neurological outcomes in clinical practice, its optimal value concerning maximum (BISmax), minimum (BISmin) and mean (BISmean) on accurately predicting the prognosis of patients with hypoxic-ischemic encephalopathy (HIE) after resuscitation has not been clearly determined. " 01/01/2018 - "The maximum value of bispectral index predicts outcome in hypoxic-ischemic encephalopathy after resuscitation, better than minimum or mean value."
5.	Hyperbaric Oxygenation 05/01/2019 - "To assess the efficacy of hyperbaric oxygen therapy (HBOT) in patients with hypoxic ischemic encephalopathy (HIE). " 04/01/2008 - "[Efficacy of hyperbaric oxygen therapy under different pressures on neonatal hypoxic-ischemic encephalopathy]." 05/01/2019 - "Hyperbaric oxygen therapy in patients with hypoxic ischemic encephalopathy." 03/01/2006 - "Hyperbaric oxygenation (HBO) is an attractive procedure that has been used in treatment of hypoxic-ischemic encephalopathy (HIE). " 01/01/2021 - "Hyperbaric oxygen therapy for hypoxic-ischemic encephalopathy in non-fatal drowning."