|4.||Brain Edema (Cerebral Edema)
|1.||Zhu, Changlian: 10 articles (01/2014 - 07/2003)|
|2.||Blomgren, Klas: 9 articles (01/2014 - 07/2003)|
|3.||Groenendaal, Floris: 9 articles (10/2011 - 04/2004)|
|4.||Wang, Xiaoyang: 8 articles (01/2014 - 07/2003)|
|5.||Ikeda, Tomoaki: 6 articles (04/2015 - 08/2002)|
|6.||Juul, Sandra E: 6 articles (01/2015 - 04/2010)|
|7.||Shankaran, Seetha: 6 articles (03/2014 - 05/2007)|
|8.||Barks, John D E: 6 articles (07/2013 - 01/2002)|
|9.||Armstead, William M: 6 articles (01/2012 - 12/2002)|
|10.||van Bel, Frank: 6 articles (05/2010 - 04/2004)|
10/01/2014 - "Phase II and III clinical trials are currently in process to determine the safety and efficacy of neuroprotective dosing of erythropoietin for extreme prematurity and hypoxic-ischemic encephalopathy in neonates."
08/01/2009 - "Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy."
08/01/2009 - "The purpose of this study was to evaluate the efficacy and safety of erythropoietin in neonatal hypoxic-ischemic encephalopathy (HIE), by using a randomized, prospective study design. "
10/01/2015 - "To observe the one-year neurologic prognostic outcome of newborns with moderate and severe hypoxic-ischemic encephalopathy (HIE) who received recombinant human erythropoietin (rhuEPO) combined with exogenous monosialotetrahexosylganglioside (GM1) treatment to provide new guidelines for clinical treatment. "
11/01/2014 - "Erythropoietin is neuroprotective in animal models of neonatal hypoxic-ischemic encephalopathy. "
|2.||Phenobarbital (Luminal)FDA Link
01/01/2015 - "Phenobarbital is an anticonvulsive drug widely used in newborns with hypoxic-ischemic encephalopathy. "
08/01/2010 - "Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy."
06/01/2010 - "Four of the patients in whom there was no increase in serum phenobarbital levels had hypoxic-ischemic encephalopathy. "
12/01/2005 - "Asphyxiated neonates (gestational age >or= 34 weeks) manifesting with hypoxic ischemic encephalopathy (HIE) in the first six hours of life were randomized to receive either injection of phenobarbital 20 mg/kg IV or to the control group. "
12/01/2005 - "A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy."
12/01/2015 - "Neonatal research networks have led the way in conducting many of the most important clinical trials of the last 25 years, including studies of cooling for hypoxic-ischemic encephalopathy, delivery room management with less invasive support, and oxygen saturation targeting. "
08/01/2005 - "The aim of the study was to determine whether neonates resuscitated with room air compared with 100 per cent oxygen in the delivery room were less likely to have hypoxic ischemic encephalopathy and/or death before discharge. "
01/01/2015 - "Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. "
01/01/2014 - "Newborns with hypoxic ischemic encephalopathy (HIE) are at risk for coagulopathy due to systemic oxygen deprivation. "
09/01/2013 - "Hypoxic ischemic encephalopathy is a serious condition due to inadequate oxygen supply to the brain. "
|4.||Phosphopyruvate Hydratase (Enolase)IBA
03/01/2009 - "To examine electroencephalographic (EEG) background patterns and serum neuron specific enolase (NSE) levels in neonates with hypoxic-ischemic encephalopathy (HIE) in order to study their roles in assessing clinical progress, severity and prognosis in children with HIE. "
09/01/2004 - "The aim of this study was to evaluate serum concentrations of neuron-specific enolase (NSE) as a marker of the severity of hypoxic ischemic encephalopathy (HIE) and to elucidate the relation among the concentrations of NSE, grade of HIE and short-term outcome. "
03/01/2009 - "[Changes of electroencephalographic background patterns and serum neuron specific enolase levels in neonates with hypoxic-ischemic encephalopathy]."
09/01/2004 - "Neuron-specific enolase as a marker of the severity and outcome of hypoxic ischemic encephalopathy."
11/01/2002 - "Cerebrospinal fluid neuron-specific enolase levels of the 7 newborns in the hypoxic-ischemic encephalopathy grade 3 group were also significantly higher than the 5 in the hypoxic-ischemic encephalopathy grade 1 group. "
|5.||Pentoxifylline (Trental)FDA LinkGeneric
09/01/2014 - "The aim of this study was to evaluate the effects of post-ischemic pentoxifylline (PTX) therapy on the gut injury in neonatal rat model of hypoxic ischemic encephalopathy (HIE). "
11/01/2013 - "The aim of this study was to evaluate the effects of postischemic treatment with pentoxifylline on the cytokine gene expressions and neuronal apoptosis in neonatal rat model of hypoxic-ischemic encephalopathy. "
09/01/2014 - "Pentoxifylline therapy attenuates intestinal injury in rat pups with hypoxic ischemic encephalopathy."
11/01/2013 - "The effects of intraperitoneal pentoxifylline treatment in rat pups with hypoxic-ischemic encephalopathy."
10/01/2010 - "Results of experimental studies also indicate that pentoxifylline may potentially be beneficial in meconium aspiration syndrome and hypoxic ischemic encephalopathy. "
|6.||Lactic AcidFDA LinkGeneric
01/01/1986 - "We conclude that CSF lactate determinations may be helpful in the evaluation of perinatal hypoxic-ischemic encephalopathy."
05/01/2012 - "We conducted this study to compare the strong ion gap (SIG) with base excess (BE) and lactate for predicting neurologic outcome measured by magnetic resonance imaging (MRI) in newborns with hypoxic-ischemic encephalopathy (HIE). "
01/01/2015 - "Significantly higher concentrations of lactate (p 8.7 mmol/L with 80 % sensitivity and 82% specificity indicated the development of the hypoxic-ischemic encephalopathy stage II/III, while the lactate level>9.95 mmol/L was a predictor of death, with 75% sensitivity and 74.4% specificity. "
01/01/2015 - "In routine clinical practice, after an admission to the Intensive Care Unit, lactate concentration was determined in capillary blood samples during the first one to six hours after birth in 55 term newborns with the post-asphyxial hypoxic-ischemic encephalopathy. "
06/01/2013 - "MRI was abnormal in 32% of neonates, 29.5% of whom were imaged at DOL 4 to 8. rADC values were lowest in neonates scanned on DOL 4 and 5 and remained low up to DOL 8. The deep brain nuclei were involved in hypoxic ischemic encephalopathy in 93% of neonates with abnormal MRIs and lactate was identified on MRS in 18% of neonates between DOL 4 and 8. MRI performed after therapeutic cooling was abnormal in 29.5% of neonates scanned on DOL 4 to 8. Deep nuclear injury was identified in 93% of neonates. "
|7.||Insulin-Like Growth Factor I (IGF-1)IBA
11/23/2005 - "In conclusion, IGF-1 provided potent neuroprotection to OPCs and improved neurological functions following cerebral hypoxia-ischemia in the neonatal rat. "
11/23/2005 - "IGF-1 treatment attenuated damages to OPCs and improved neurological functions after cerebral hypoxia-ischemia. "
11/23/2005 - "IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat."
04/18/2011 - "Whole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia-ischemia."
02/01/2007 - "To study the serum levels of insulin-like growth factor I(IGF-I)and growth hormone (GH) in neonates with hypoxic-ischemic encephalopathy (HIE) and to investigate the relationship of serum levels of IGF-I and GH with the severity of HIE. "
|8.||Glutathione (Reduced Glutathione)IBA
01/01/2015 - "Since oligodendrocyte progenitor cells (OPCs) are the target cells of neonatal hypoxic-ischemic encephalopathy (HIE), the present study was aimed at investigating the protective effects of N-acetyl-l-cysteine (NAC), a well-known antioxidant and precursor of glutathione, in OPCs as well as in neonatal rats. "
09/15/2009 - "In conclusion, indomethacin administration after hypoxic-ischemic encephalopathy injury has a neuroprotective effect since it inhibits caspase activity and reverses the depletion of glutathione. "
09/15/2009 - "The aim of this study was to investigate the effects of indomethacin, a nonselective cyclooxygenase inhibitor, on caspase activity, glutathione levels and lipid peroxidation in newborn rats with hypoxic-ischemic encephalopathy. "
10/01/2014 - "Although Y1472 phosphorylation is important for synaptic plasticity, it is unknown whether it is involved in NMDA receptor-mediated excitotoxicity in neonatal brain hypoxia-ischemia (HI). "
06/01/2006 - "[Effect of brain hypoxia-ischemia on expression of phosphorylated NMDA receptor-1 subunit of cerebral cortex cells]."
03/01/2005 - "The effects of transient cerebral hypoxia-ischemia (HI) on phosphorylation of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor were investigated in 7 (P7)- and 21 (P21)-day-old rats. "
02/01/1995 - "N-methyl-D-aspartate (NMDA) receptor antagonists have been demonstrated widely to be neuroprotective in cerebral ischemia, hypoxia, and traumatic brain injury. "
03/10/1988 - "We assessed the cerebral protective effects of the noncompetitive N-methyl-D-aspartate antagonist dextromethorphan (DM; 10-35 mg/kg i.p.) in 8-day-old rats that were subjected to brain hypoxia-ischemia by tying one carotid artery and placing them in 8% O2-92% N2 for 2 h. "
|10.||topiramate (Topamax)FDA LinkGeneric
01/01/2012 - "Safety and efficacy of topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia (NeoNATI)."
09/01/2010 - "Oral topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia: a safety study."
01/01/2012 - "Topiramate has been proven to reduce brain injury in animal models of neonatal hypoxic ischemic encephalopathy. "
11/01/2009 - "Topiramate concentrations in neonates treated with prolonged whole body hypothermia for hypoxic ischemic encephalopathy."
01/01/2012 - "Term newborns (gestational age ≥ 36 weeks and birth weight ≥ 1800 g) with precocious metabolic, clinical and electroencephalographic (EEG) signs of hypoxic-ischemic encephalopathy will be randomized, according to their EEG pattern, to receive topiramate added to standard treatment with moderate hypothermia or standard treatment alone. "
09/01/2015 - "The hypoxia-ischemia brain injury models were made by ligature of the left common carotid artery and then inhalation of 8%O(2)/92%N(2) for 2 h. "
01/01/2014 - "To establish the hypoxic-ischemic encephalopathy (HIE) model, the pups from the HI group were subjected to left common carotid artery ligation followed by exposure to 8% O2 and 92% N2. "
02/01/2013 - "To evaluate the effect of cerebral hypoxia-ischemia on memory and learning survival of rats submitted to permanent bilateral carotid ligation (PBCL). "
02/01/2008 - "coli O55:B5, 0.2mg/kg for 3 days, then 0.1mg/kg for 2 days) daily for 5 days after unilateral cerebral hypoxia-ischemia (right carotid ligation followed by 35min in 10% O2) in 10-day-old mice resulted in increased right forebrain tissue damage (35.6% reduction in right hemisphere volume compared to 20.6% reduction in saline-injected controls), in bilateral reductions in corpus callosum area (by 12%) and myelin basic protein immunostaining (by 19%), and in suppression of injury-related right subventricular zone cellular proliferation. "
02/01/1987 - "Cerebral hypoxia-ischemia was produced in 1-week-old rats by exposing them to 8% O2-92% N2 commencing 4 to 6 h after unilateral carotid artery ligation. "
01/01/2013 - "The efficacy of induced hypothermia to treat hypoxic-ischemic encephalopathy (HIE) in term infants has been evaluated in 6 multicenter randomized controlled trials. "
12/01/2009 - "Systemic hypothermia induced within 10 hours after birth improved neurological outcome in newborns with hypoxic-ischemic encephalopathy."
01/01/2013 - "Induced hypothermia to treat neonatal hypoxic-ischemic encephalopathy. "
04/01/2012 - "The advent of induced mild hypothermia for acute neonatal hypoxic-ischemic encephalopathy in 2005 has been responsible for renewed urgency in the development of precise and reliable neonatal neurodiagnostic techniques. "
01/01/2011 - "Induced hypothermia for neonatal hypoxic-ischemic encephalopathy: pathophysiology, current treatment, and nursing considerations."
01/01/2008 - "A trend toward a decrease in the risk of hypoxic ischemic encephalopathy stage 2 and 3 was noted with resuscitation in 21% O(2) in the analysis of all studies (typical RR 0.88, 95% CI 0.72, 1.08). "
06/02/2015 - "The most common cause was cerebrovascular disease (46.3%) followed by ischemic-hypoxic encephalopathy after cadio-pulmonary resuscitation (18.5%). "
01/01/2014 - "Apgar score at 5 minutes, time to first breath, onset of the first cry, duration of resuscitation, death or moderate to severe hypoxic-ischemic encephalopathy within 7 days of life. "
05/01/2009 - "The leading cause of morbidity and mortality after successful resuscitation is hypoxic-ischemic encephalopathy (HIE), which results in neuronal loss within the neocortex and the hippocampal formation. "
02/01/2004 - "We report here the results of experiments using newborn piglets subjected to severe transient cerebral hypoxia-ischemia followed by resuscitation. "
|4.||Chinese Traditional Medicine (Traditional Chinese Medicine)
03/01/2013 - "To investigate the protective effects of Shengui tablet (Chinese Traditional Medicine) on experimental cerebral ischemia by acute cerebral ischemia hypoxia in mice and bilateral ligation of the carotid artery in rats. "
03/01/1994 - "The protective effects of Kamikihi-To (KMK), a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia were investigated with various experimental models in mice and gerbils. "
03/01/1994 - "Protective effects of kamikihi-to, a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia in mice and gerbils."
|5.||Neonatal Intensive Care
06/01/2014 - "We reviewed all brain MRI studies from the neonatal intensive care unit (NICU) at our university medical center over a 4-year period to identify cases that were radiographically normal (23 cases) and those with diffuse, global hypoxic-ischemic encephalopathy (12 cases). "
06/01/2015 - "Between January 2011 and June 2013, 133 hypoxic-ischemic encephalopathy patients being followed up in the neonatal intensive care unit of Dr. Sami Ulus Maternity and Children's Hospital are prospectively evaluated. "
09/01/2012 - "The main outcomes were neonatal death, newborn respiratory distress, need for orotracheal intubation and neonatal intensive care unit (NICU), and hypoxic-ischemic-encephalopathy. "
02/01/2012 - "Twenty of 33 (61%) were admitted directly to the neonatal intensive care unit because of perinatal depression or evolving hypoxic-ischemic encephalopathy. "
03/01/1998 - " Also recorded in the amnioinfusion group were significant reductions in the following perinatal morbidity measures: 5-minute Apgar score below 7, neonatal intensive care admissions, neonatal ventilation, and hypoxic ischemic encephalopathy. "