Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain)

367  relevant articles (16 outcomes, 45 trials/studies) found for this Disease

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Relationship Network

Disease Context: Research Results

Related Diseases

1.	Brain Edema (Cerebral Edema)
2.	Infection
3.	Anoxia (Hypoxia)
4.	Stroke (Strokes)
5.	Hepatic Encephalopathy

Experts

1.	Blomgren, K: 5 articles (04/2007 - 08/2000)
2.	Hagberg, H: 5 articles (04/2007 - 08/2000)
3.	Wang, X: 4 articles (04/2007 - 08/2000)
4.	Zhu, Changlian: 3 articles (08/2007 - 01/2004)
5.	Zhu, C: 3 articles (04/2007 - 08/2000)
6.	Gazzolo, Diego: 3 articles (03/2007 - 01/2004)
7.	Ikenoue, Tsuyomu: 3 articles (11/2005 - 02/2005)
8.	Burns, Kevin A: 2 articles (06/2008 - 11/2007)
9.	Kuan, Chia-Yi: 2 articles (06/2008 - 11/2007)
10.	Adhami, Faisal: 2 articles (06/2008 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Brain Hypoxia-Ischemia:

1.	OxygenIBA 04/01/2008 - "Efficacy of hyperbaric oxygen therapy under different pressures on neonatal hypoxic-ischemic encephalopathy]" 08/01/2005 - "The aim of the study was to determine whether neonates resuscitated with room air compared with 100 per cent oxygen in the delivery room were less likely to have hypoxic ischemic encephalopathy and/or death before discharge" 04/01/2008 - "OBJECTIVE: Some research has shown that hyperbaric oxygen (HBO) can decrease the rate of mortality and disability caused by hypoxic-ischemic encephalopathy (HIE) in neonates" 12/01/2007 - "Despite the relative frequency of neonatal hypoxic-ischemic encephalopathy, the immature brain sustains relatively less damage than an adult who experiences a similar crisis of oxygen and nutrient deprivation" 06/28/2002 - "We induced cerebral hypoxia-ischemia by bilateral clamping of the common carotid arteries and ventilation with 8% oxygen for 20 min followed by 3 h of reoxygenation/reperfusion" Order ALL the reference details at left...
2.	Insulin-Like Growth Factor I (IGF-1)IBA 11/23/2005 - "In conclusion, IGF-1 provided potent neuroprotection to OPCs and improved neurological functions following cerebral hypoxia-ischemia in the neonatal rat" 11/23/2005 - "IGF-1 treatment attenuated damages to OPCs and improved neurological functions after cerebral hypoxia-ischemia" 11/23/2005 - "IGF-1 protects oligodendrocyte progenitor cells and improves neurological functions following cerebral hypoxia-ischemia in the neonatal rat." 02/01/2007 - "OBJECTIVE: To study the serum levels of insulin-like growth factor I(IGF-I)and growth hormone (GH) in neonates with hypoxic-ischemic encephalopathy (HIE) and to investigate the relationship of serum levels of IGF-I and GH with the severity of HIE" 02/01/2007 - "Relationship between serum levels of insulin-like growth factor I and growth hormone and neonatal hypoxic-ischemic encephalopathy]" Order ALL the reference details at left...
3.	Lactic AcidFDA LinkGeneric 01/01/1986 - "We conclude that CSF lactate determinations may be helpful in the evaluation of perinatal hypoxic-ischemic encephalopathy." 01/01/2008 - "OBJECTIVE: To establish a simple and quick method that could be used to predict the occurrence of hypoxic ischemic encephalopathy (HIE) as early as possible by investigating the variations of nucleated red blood cells per 100 white blood cell (NRBC/100 WBC) counts and lactate levels in cord blood" 01/01/2008 - "The combined detection of umbilical cord nucleated red blood cells and lactate: early prediction of neonatal hypoxic ischemic encephalopathy." 11/01/1999 - "CONCLUSIONS: Our findings suggest that determination of the lactate concentration in fetal scalp blood is a more sensitive diagnostic tool than is determination of the pH value for predicting either an Apgar score <4 at 5 minutes or moderate to severe hypoxic-ischemic encephalopathy" 11/01/1999 - "The areas under the receiver operating characteristic curves were significantly higher for the lactate concentration than for the pH value with 2 outcome variables: Apgar score <4 at 5 minutes (P =.033) and moderate to severe hypoxic-ischemic encephalopathy (P =.015)" Order ALL the reference details at left...
4.	N-Methylaspartate (NMDA)IBA 03/01/2005 - "The effects of transient cerebral hypoxia-ischemia (HI) on phosphorylation of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor were investigated in 7 (P7)- and 21 (P21)-day-old rats" 02/01/1995 - "N-methyl-D-aspartate (NMDA) receptor antagonists have been demonstrated widely to be neuroprotective in cerebral ischemia, hypoxia, and traumatic brain injury" 03/10/1988 - "We assessed the cerebral protective effects of the noncompetitive N-methyl-D-aspartate antagonist dextromethorphan (DM; 10-35 mg/kg i.p.) in 8-day-old rats that were subjected to brain hypoxia-ischemia by tying one carotid artery and placing them in 8% O2-92% N2 for 2 h" 08/01/2002 - "The effect of cerebral hypoxia-ischemia (HI) on levels and tyrosine phosphorylation of the NMDA receptor was examined in 7- (P7) and 21 (P21)-day-old rats" 08/15/1998 - "The extracellular acidity that accompanies brain hypoxia-ischemia is known to reduce both NMDA and AMPA-kainate receptor-mediated currents and NMDA receptor-mediated neurotoxicity" Order ALL the reference details at left...
5.	Vitamin EFDA Link 01/01/1999 - "Twenty rat pups received an intraperitoneal injection of 30 mg/kg body weight methylprednisolone and vitamin E (100 U/kg) immediately following cerebral hypoxia-ischemia" 01/01/1999 - "To study the efficacy of methylprednisolone/vitamin E in reducing cerebral edema and improving the ultimate neuropathological outcome in perinatal cerebral hypoxia-ischemia, 40 seven-day postnatal rats were subjected to right common carotid artery ligation followed by exposure to 8% oxygen at 37 degrees C for 3 h" Order ALL the reference details at left...
6.	MethylprednisoloneFDA LinkGeneric 01/01/1999 - "Twenty rat pups received an intraperitoneal injection of 30 mg/kg body weight methylprednisolone and vitamin E (100 U/kg) immediately following cerebral hypoxia-ischemia" 01/01/1999 - "To study the efficacy of methylprednisolone/vitamin E in reducing cerebral edema and improving the ultimate neuropathological outcome in perinatal cerebral hypoxia-ischemia, 40 seven-day postnatal rats were subjected to right common carotid artery ligation followed by exposure to 8% oxygen at 37 degrees C for 3 h" Order ALL the reference details at left...
7.	Mannitol (Osmitrol)FDA LinkGeneric 08/01/1990 - "Twenty-seven rat pups received a subcutaneous injection of 0.1 ml mannitol in a dosage of 4 mg/kg body wt immediately following cerebral hypoxia-ischemia and every 12 hours thereafter for a total of four doses" 08/01/1990 - "To study the efficacy of mannitol in reducing cerebral edema and improving the ultimate neuropathologic outcome in perinatal cerebral hypoxia-ischemia, 67 7-day postnatal rats were subjected to unilateral common carotid artery ligation followed by exposure to 8% oxygen at 37 degrees C for 3 hours" Order ALL the reference details at left...
8.	ProstaglandinsIBA 11/01/1987 - "A possible role of endogenously formed cerebral prostaglandins in the development of adaptive protection against cerebral hypoxia/ischemia in mice." 02/01/2005 - "3) Release of prostaglandins, endothelin-1, complement proteins, and matrix metalloproteinase-9 by microvascular endothelial cells are other components in the complex mechanism of brain ischemia/hypoxia" Order ALL the reference details at left...
9.	Caffeine (No Doz)FDA LinkGeneric 03/01/2008 - "CONCLUSIONS AND CLINICAL IMPORTANCE: Doxapram is more effective than caffeine for rapid correction of hypercapnia in foals with hypoxic-ischemic encephalopathy." 03/01/2008 - "HYPOTHESIS: Caffeine and doxapram alleviate hypercapnia in foals with hypoxic-ischemic encephalopathy" 03/01/2008 - "Retrospective comparison of caffeine and doxapram for the treatment of hypercapnia in foals with hypoxic-ischemic encephalopathy." 12/01/2008 - "Current strategies to decrease the risk of cerebral palsy include interventions to prolong pregnancy (eg, 17alpha-progesterone), limiting the number of multiple gestations related to assisted reproductive technology, antenatal steroids for mothers expected to deliver prematurely, caffeine for extremely low birth weight neonates, and induced hypothermia for a subgroup of neonates diagnosed with hypoxic-ischemic encephalopathy." Order ALL the reference details at left...
10.	huperzine AIBA 09/13/2002 - "The significant protection against HI injury on behavior and neuropathology was produced by huperzine A at the dose of 0.1 mg/kg. These findings suggest that huperzine A might be beneficial in the treatment of hypoxic-ischemic encephalopathy in neonates." 01/01/2003 - "Huperzine A showed a therapeutic potential for the treatment of hypoxic-ischemic encephalopathy (HIE) caused by the perinatal asphyxia." Order ALL the reference details at left...

Therapies and Procedures

1.	Ligation 02/01/2008 - "coli O55:B5, 0.2mg/kg for 3 days, then 0.1mg/kg for 2 days) daily for 5 days after unilateral cerebral hypoxia-ischemia (right carotid ligation followed by 35min in 10% O2) in 10-day-old mice resulted in increased right forebrain tissue damage (35.6% reduction in right hemisphere volume compared to 20.6% reduction in saline-injected controls), in bilateral reductions in corpus callosum area (by 12%) and myelin basic protein immunostaining (by 19%), and in suppression of injury-related right subventricular zone cellular proliferation" 02/01/1987 - "Cerebral hypoxia-ischemia was produced in 1-week-old rats by exposing them to 8% O2-92% N2 commencing 4 to 6 h after unilateral carotid artery ligation" 07/01/2003 - "Unilateral cerebral hypoxia-ischemia (HI) was induced in 7-day-old rats by ligation of the left carotid artery and hypoxia (7.7% O2) for 55 min. AIF release from mitochondria and AIF translocation to nuclei was detected immediately after HI, and only in damaged areas, as judged by the concurrent loss of MAP-2" 06/18/1997 - "The most frequently used model of neonatal cerebral hypoxia-ischemia consists of a 7-day postnatal rat model with combined common carotid artery ligation and hypoxemia" 09/01/1990 - "In a preceding paper, we showed that the exposure to hypoxia after unilateral carotid artery ligation of sucking rat on 7 days of age caused various pathological changes in the ipsilateral forebrain, which had close similarity to human perinatal hypoxic-ischemic encephalopathy" Order ALL the reference details at left...
2.	Induced Hypothermia 05/01/2007 - "This article highlights the pathophysiology of hypoxic-ischemic encephalopathy and the rationale behind the effectiveness of induced hypothermia" 05/01/2007 - "Induced hypothermia for neonates with hypoxic-ischemic encephalopathy." 01/16/2004 - "Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia." 07/01/2003 - "There also have been preliminary clinical studies of induced hypothermia in patients with severe stroke, newborn hypoxic-ischemic encephalopathy, neurologic infection, and hepatic encephalopathy, with promising results" 12/01/2008 - "Current strategies to decrease the risk of cerebral palsy include interventions to prolong pregnancy (eg, 17alpha-progesterone), limiting the number of multiple gestations related to assisted reproductive technology, antenatal steroids for mothers expected to deliver prematurely, caffeine for extremely low birth weight neonates, and induced hypothermia for a subgroup of neonates diagnosed with hypoxic-ischemic encephalopathy." Order ALL the reference details at left...
3.	Neonatal Intensive Care 03/01/1998 - "Also recorded in the amnioinfusion group were significant reductions in the following perinatal morbidity measures: 5-minute Apgar score below 7, neonatal intensive care admissions, neonatal ventilation, and hypoxic ischemic encephalopathy" 01/01/1998 - "METHODS: Five hundred forty-five consecutive neonatal intensive care unit deaths (338 autopsied, rate 62%) in a regional tertiary/quaternary care neonatal intensive care unit for referred infants (65,000 annual births) were classified in six clinical diagnostic groups (anomalies, cardiac anomalies, hypoxic ischemic encephalopathy, prematurity and its complications, infections, and other) and rated in three levels of certainty of clinical diagnosis as "gold standard" certainty, almost complete certainty, and less certain than the latter" 09/01/2002 - "All infants transferred to the neonatal intensive care unit were studied, and those with neonatal seizures secondary to hypoxic ischemic encephalopathy were identified" 09/01/2001 - "Between 1994 and 2000, 30 full-term newborns affected by seizures secondary to hypoxic-ischemic encephalopathy, underwent computerised, polygraphic, video-EEG recordings during the first 48 hours of life, in our neonatal intensive care unit" 06/01/1993 - "In order to check the prognostic implications of EEG tracings in hypoxic-ischemic encephalopathy (HIE), we carried out prospective EEG recordings in 116 newborn babies (65 term and 51 premature) admitted to our neonatal intensive care unit as a result of perinatal asphyxia" Order ALL the reference details at left...
4.	Chinese Traditional Medicine (Traditional Chinese Medicine) 03/01/1994 - "The protective effects of Kamikihi-To (KMK), a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia were investigated with various experimental models in mice and gerbils" 03/01/1994 - "Protective effects of kamikihi-to, a traditional Chinese medicine, against cerebral ischemia, hypoxia and anoxia in mice and gerbils." Order ALL the reference details at left...
5.	Resuscitation 01/01/2008 - "A trend toward a decrease in the risk of hypoxic ischemic encephalopathy stage 2 and 3 was noted with resuscitation in 21% O(2) in the analysis of all studies (typical RR 0.88, 95% CI 0.72, 1.08)" 02/01/2004 - "We report here the results of experiments using newborn piglets subjected to severe transient cerebral hypoxia-ischemia followed by resuscitation" 07/01/1989 - "Health workers must be familiar with proper resuscitation techniques, especially avoidance of excessive suctioning of the pharynx, and be alert to signs of hypoxic ischemic encephalopathy" 07/01/1978 - "Resuscitation after global brain ischemia-anoxia." 02/01/2001 - "The perinatal variables associated to risk of neurologic sequelae on univariate analysis are variables of neonatal resuscitation (1 minute Apgar score < or = 4, 5 minute Apgar score < or = 6, endotracheal intubation, severity of PA) and variables of systemic manifestations (hypoxic-ischemic encephalopathy, cardiovascular and multi-systemic dysfunction, and mechanical ventilation)" Order ALL the reference details at left...