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trkA Receptor

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Also Known As:
Receptor, trkA; Neurotrophic Tyrosine Kinase Receptor Type 1; Proto-Oncogene Products c-trk; c-trk Protein; gp140 c-trk; p140-trkA; trk1 Transforming Tryrosine Kinase; Proto Oncogene Products c trk; Proto Oncogene Protein trk; Proto-Oncogene Protein, trk; Receptor, NTRK1; c trk Protein; c-trk, Proto-Oncogene Products; c-trk, gp140; gp140 c trk; p140 trkA; trk Proto Oncogene Protein; trk, Proto-Oncogene Protein; NTRK1 Receptor; Proto-Oncogene Protein trk; Receptor, Neurotrophic Tyrosine Kinase Type 1; gp140(c-TRK); trk Proto-Oncogene Protein
Networked: 114 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Brodeur, G M: 6 articles (01/2001 - 04/2000)
2. Eggert, A: 6 articles (01/2001 - 04/2000)
3. Ikegaki, N: 6 articles (01/2001 - 04/2000)
4. Cattaneo, Antonino: 5 articles (10/2013 - 07/2004)
5. Lazarovici, Philip: 4 articles (01/2007 - 06/2003)
6. Liu, X G: 4 articles (01/2001 - 07/2000)
7. Eggert, Angelika: 3 articles (11/2014 - 03/2002)
8. Covaceuszach, Sonia: 3 articles (01/2011 - 07/2004)
9. Saragovi, H Uri: 3 articles (06/2007 - 02/2004)
10. Davidson, Ben: 3 articles (01/2007 - 06/2003)

Related Diseases

1. Pheochromocytoma
2. Neoplasms (Cancer)
3. Pain (Aches)
4. Inflammation
5. Pterygium

Related Drugs and Biologics

1. Protein-Tyrosine Kinases (Tyrosine Kinase)
2. Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
3. Nerve Growth Factor (NGF)
4. Carbon Monoxide
5. Nerve Growth Factor Receptors (Neurotrophin Receptors)
6. Neutralizing Antibodies
7. Angiogenesis Inducing Agents (Angiogenesis Factor)
8. Phosphotransferases (Kinase)
9. Tropomyosin
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Intravitreal Injections
2. Intraocular Injections
3. Intradermal Injections
4. Analgesia