omega-Agatoxin IVA

A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.

Also Known As:

Networked: 20 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Asakura, K: 2 articles (08/2000 - 04/2000)
2.	Kagawa, K: 2 articles (08/2000 - 04/2000)
3.	Kanemasa, T: 2 articles (08/2000 - 04/2000)
4.	Minagawa, K: 2 articles (08/2000 - 04/2000)
5.	Ninomiya, M: 2 articles (08/2000 - 04/2000)
6.	Allana, T N: 1 article (07/2008)
7.	Lin, J-W: 1 article (07/2008)
8.	Chen, Chien-Chuan: 1 article (01/2006)
9.	Cheng, Jen-Kun: 1 article (01/2006)
10.	Chiou, Lih-Chu: 1 article (01/2006)

Related Diseases

1.	Neurogenic Inflammation 08/04/2000 - "In this study, we investigated the effect of alpha-eudesmol, which potently inhibits the presynaptic omega-agatoxin IVA-sensitive (P/Q-type) Ca(2+) channel, on neurogenic inflammation following electrical stimulation of rat trigeminal ganglion. " 08/04/2000 - "We also suggest that the omega-agatoxin IVA-sensitive Ca(2+) channel blocker, alpha-eudesmol, may become useful for the treatment of the neurogenic inflammation in the trigemino-vascular system such as migraine."
2.	Reflex Epilepsy (Photosensitive Epilepsy) 07/01/1996 - "Omega-Conotoxin MVIIC (0.1, 0.3 micrograms ICV/mouse) and omega-agatoxin IVA (0.1, 0.3, 1 micrograms ICV), which act predominantly at P- and/or Q-type calcium channels, prevented clonic and tonic sound-induced seizures in this animal model of reflex epilepsy (ED50 values with 95% confidence limits for protection against clonic sound-induced seizures were 0.09 (0.04-0.36) micrograms ICV and 0.09 (0.05-0.15) micrograms ICV respectively and against tonic seizures 0.07 (0.03-0.16) micrograms ICV and 0.08 (0.04-0.13) micrograms ICV, respectively). "
3.	Seizures (Absence Seizure) 07/01/1996 - "Omega-Conotoxin MVIIC (0.1, 0.3 micrograms ICV/mouse) and omega-agatoxin IVA (0.1, 0.3, 1 micrograms ICV), which act predominantly at P- and/or Q-type calcium channels, prevented clonic and tonic sound-induced seizures in this animal model of reflex epilepsy (ED50 values with 95% confidence limits for protection against clonic sound-induced seizures were 0.09 (0.04-0.36) micrograms ICV and 0.09 (0.05-0.15) micrograms ICV respectively and against tonic seizures 0.07 (0.03-0.16) micrograms ICV and 0.08 (0.04-0.13) micrograms ICV, respectively). "
4.	Migraine Disorders (Migraine) 08/04/2000 - "We also suggest that the omega-agatoxin IVA-sensitive Ca(2+) channel blocker, alpha-eudesmol, may become useful for the treatment of the neurogenic inflammation in the trigemino-vascular system such as migraine."
5.	Hypotension (Low Blood Pressure) 01/01/1999 - "This study assesses the effect of neuronal voltage-sensitive Ca2+ channel blockers, omega-conotoxin GVIA (CTX), and omega-agatoxin IVA (AgTX) on the vasodilation and release of calcitonin gene-related peptide (CGRP), both of which were induced by either application of capsaicin or acute stepwise hypotension. "

Related Drugs and Biologics

1.	alpha-eudesmol
2.	Q-Type Calcium Channels (Q-Type Calcium Channel)
3.	omega-conotoxin-MVIIC
4.	omega-Conotoxin GVIA
5.	Calcitonin Gene-Related Peptide
6.	Capsaicin (Zostrix)
7.	omega-Agatoxin IVA
8.	Nimodipine (Modus)
9.	Glutamic Acid (Glutamate)
10.	Verapamil (Calan)

Related Therapies and Procedures

1.	Ligation