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Selective Estrogen Receptor Modulators (SERM)

A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63)
Also Known As:
SERM; Selective Estrogen Receptor Modulator; SERMs; Estrogen Receptor Modulator, Selective; Estrogen Receptor Modulators, Selective
Networked: 1321 relevant articles (111 outcomes, 209 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Jordan, V Craig: 30 articles (07/2013 - 01/2002)
2. Komm, Barry S: 18 articles (09/2015 - 09/2005)
3. Thatcher, Gregory R J: 15 articles (05/2014 - 10/2003)
4. Jordan, V C: 14 articles (01/2007 - 01/2000)
5. Bolton, Judy L: 13 articles (05/2014 - 10/2003)
6. Gennari, Luigi: 12 articles (04/2012 - 04/2004)
7. McDonnell, Donald P: 10 articles (11/2015 - 07/2002)
8. Vogel, Victor G: 10 articles (01/2015 - 03/2004)
9. Mirkin, Sebastian: 8 articles (08/2015 - 11/2013)
10. Wickerham, D Lawrence: 8 articles (01/2015 - 01/2005)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Osteoporosis
3. Neoplasms (Cancer)
4. Postmenopausal Osteoporosis
5. Leiomyoma (Uterine Fibroids)

Related Drugs and Biologics

1. Selective Estrogen Receptor Modulators (SERM)
2. Tamoxifen
3. Raloxifene (Evista)
4. Estrogens (Estrogen)
5. Hormones
6. Aromatase Inhibitors
7. tartrate salt cis- 1R- (4'- pyrrolidinoethoxyphenyl)- 2S- phenyl- 6- hydroxy- 1,2,3,4- tetrahydronaphthalene (Lasofoxifene)
8. Toremifene (Fareston)
9. Diphosphonates
10. Estradiol (Estrace)

Related Therapies and Procedures

1. Chemoprevention
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Drug Therapy (Chemotherapy)
4. Estrogen Replacement Therapy
5. Heterologous Transplantation (Xenotransplantation)