SOS1 Protein

A mammalian homolog of the DROSOPHILA SON OF SEVENLESS PROTEIN. It is a guanine nucleotide exchange factor for RAS PROTEINS.

Also Known As:

mSOS1 Protein; Son of Sevenless Homolog 1

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        ras Guanine Nucleotide Exchange Factors: 25
        Son of Sevenless Proteins: 4
        SOS1 Protein: 15
        human SOS1 protein: 1
        mouse Sos1 protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        ras Guanine Nucleotide Exchange Factors: 25
        Son of Sevenless Proteins: 4
        SOS1 Protein: 15
        human SOS1 protein: 1
        mouse Sos1 protein

Experts

1.	Ha, Si: 1 article (01/2022)
2.	Liu, Guodong: 1 article (01/2022)
3.	Liu, Yan: 1 article (01/2022)
4.	Mao, Honggang: 1 article (01/2022)
5.	Zhang, Xiaoyan: 1 article (01/2022)
6.	Zhang, Zun: 1 article (01/2022)
7.	Cheng, Min: 1 article (09/2021)
8.	Dai, Jiemin: 1 article (09/2021)
9.	Sun, Feiji: 1 article (09/2021)
10.	Ye, Xiaolin: 1 article (09/2021)

Related Diseases

1.	Hypoxia (Hypoxemia) 07/01/2017 - "There were 12 pathways, which significantly responded to hypoxia (P<0.05) and the pathway with the highest significance was the chemokine signaling pathway (P=0.0001), which comprised 28 genes, including C‑C motif ligand (CCL)1, C‑X‑C motif ligand (CXCL)9, CXCL10, son of sevenless homolog 1, AKT serine/threonine kinase 2, Rho‑associated protein kinase 1, vav guanine nucleotide exchange factor 1, CCL17, arrestin β1 and C‑C motif chemokine receptor 2. In conclusion, the present study showed that leptin and hypoxia altered the proﬁles of gene expression in L929 cells. "
2.	Neoplasms (Cancer) 01/01/2023 - "Blocking the interaction between Ras and Son of Sevenless homolog 1 (SOS1) has been an attractive therapeutic strategy for treating cancers involving oncogenic Ras mutations. " 11/20/2016 - "The association of Ras and Sos1 protein expression with the tumor-free survival time of the patients awaits further investigation with a larger sample size." 01/01/2022 - "miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma." 04/29/2021 - "Bioinformatic analyses predicted that APEX1 might interact with cell division cycle 42 (CDC42) and son of sevenless homolog 1 (SOS1), which are involved in tumor metastasis. "
3.	Neoplasm Metastasis (Metastasis) 12/31/2022 - "The influence of son of sevenless homolog 1 (SOS1) on invasion and metastasis of hepatocellular carcinoma (HCC) cells was investigated. " 04/29/2021 - "Bioinformatic analyses predicted that APEX1 might interact with cell division cycle 42 (CDC42) and son of sevenless homolog 1 (SOS1), which are involved in tumor metastasis. "
4.	Thymoma (Thymic Carcinoma) 08/01/2013 - "Employing leading-edge subset analysis and real-time PCR assays, we observed that several genes, such as growth factor receptor-bound protein 2 (Grb2), son of sevenless homolog 1 (Sos1), SHC (Src homology 2 domain containing) transforming protein 1 (Shc1), mitogen-activated protein kinase kinase 1 (Map2k1), v-akt murine thymoma viral oncogene homolog 3 (Akt3), Elk1, ribosomal protein S6 kinase, 90 kDa, polypeptide 3 (Rps6kA3), glycogen synthase kinase 3β (Gsk3β) and casein kinase 2, alpha 1 polypeptide (Csnk2A1), which are involved in mitogenic growth factor signaling pathways, were commonly downregulated in the VSELs. "
5.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2022 - "miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma."

Related Drugs and Biologics

1.	Proto-Oncogene Proteins c-vav
2.	Leptin
3.	Chemokine Receptors
4.	Arrestin
5.	Chemokines
6.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
7.	Protein Kinases (Protein Kinase)
8.	Ligands
9.	GRB2 Adaptor Protein
10.	MAP Kinase Kinase 1