rac1 GTP-Binding Protein

A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls the development of filopodia and lamellipodia in cells and thereby influences cellular motility and adhesion. It is also involved in activation of NADPH OXIDASES. This enzyme was formerly listed as EC 3.6.1.47.

Also Known As:

Networked: 112 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Jun: 4 articles (01/2021 - 12/2015)
2.	Hudson, Laurie G: 3 articles (01/2021 - 10/2015)
3.	Wandinger-Ness, Angela: 3 articles (01/2021 - 10/2015)
4.	Bu, Fan: 3 articles (01/2021 - 10/2018)
5.	McCullough, Louise D: 3 articles (01/2021 - 10/2018)
6.	Munshi, Yashasvee: 3 articles (01/2021 - 10/2018)
7.	Li, Yi: 2 articles (01/2022 - 01/2020)
8.	Liu, Xuan: 2 articles (01/2022 - 01/2020)
9.	Wang, Li: 2 articles (01/2022 - 01/2020)
10.	Yuan, Hong: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2023 - "MicroRNA‑194‑5p attenuates hypoxia/reoxygenation‑induced apoptosis in H9C2 cardiomyocytes by inhibiting the over‑activation of RAC1 protein." 05/01/2009 - "In response to hypoxia, the levels of Rac1 protein significantly increased, reaching the maximum at 4 h, and then slowly declined. " 06/25/2006 - "To investigate the role and mechanism of Rac1 protein in the process of the human umbilical vein endothelial cell (HUVEC) senescence, we used hypoxia as a model for modulating HUVECs entering replicative senescence in vitro. " 07/01/2015 - "NO probably induces this phenotype via hypoxia-inducible factor 1α and cell division control protein 42 and Ras-related C3 botulinum toxin substrate 1 pathways. " 09/13/2011 - "Hypoxia resulted in overactivation of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activation of downstream pathways including G(αi) and Ras-related C3 botulinum toxin substrate 1. These data identify stereotyped and selective hypoxia-induced cerebral cortical disruption requiring LPA(1) signaling, inhibition of which can reduce or prevent disease-associated sequelae, and may take us closer to therapeutic treatment of fetal hypoxia-induced CNS disorders and possibly other forms of hypoxic injury."
2.	Fetal Hypoxia 09/13/2011 - "Hypoxia resulted in overactivation of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activation of downstream pathways including G(αi) and Ras-related C3 botulinum toxin substrate 1. These data identify stereotyped and selective hypoxia-induced cerebral cortical disruption requiring LPA(1) signaling, inhibition of which can reduce or prevent disease-associated sequelae, and may take us closer to therapeutic treatment of fetal hypoxia-induced CNS disorders and possibly other forms of hypoxic injury."
3.	Neoplasms (Cancer) 03/01/2023 - "Ras-related C3 botulinum toxin substrate 1 (Rac1) is abnormally expressed in a variety of tumors and plays an important role in the proliferation, invasion, and migration of tumor cells. " 01/01/2023 - "Rac1 protein could be used as an independent tumor diagnostic marker and survival predictor. " 06/11/2020 - "We have reviewed the distribution of patterns regarding the frequency of Ras-related C3 botulinum toxin substrate 1 (RAC1)-alteration(s) and their modes of actions in various cancers. " 09/23/2011 - "In particular, the role of RhoA (Ras homolog gene family, member A), Rac1 (Ras-related C3 botulinum toxin substrate 1) and Cdc42 (cell division cycle 42) in cancer progression induced by each of the three oncogenes is described. " 07/20/2022 - "Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). "
4.	Neoplasm Metastasis (Metastasis) 05/01/2021 - "Previously, we demonstrated the importance of VASP and Ras-related C3 botulinum toxin substrate 1 interactions in osteosarcoma cell migration and metastasis using Mg-63 and Saos2 cells. " 02/07/2018 - "BACKGROUND Ras-related C3 botulinum toxin substrate 1 (Rac1) is implicated in a variety of cellular functions and is related to tumor growth and metastasis. " 09/01/2020 - "Ras-related C3 botulinum toxin substrate 1 (Rac1), which is commonly upregulated in human cancer types, has been recognized as a key molecular component in tumorigenesis, invasion and metastasis. " 01/01/2018 - "We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and β1-integrin/FAK/Src signaling. " 06/08/2022 - "The contribution of the Rac1 protein to tumorigenesis, tumor progression, epithelial-mesenchymal transition of bladder cancer cells and their metastasis has been analyzed. "
5.	Breast Neoplasms (Breast Cancer) 09/01/2020 - "Although several studies have demonstrated immunolocalization of Rac1 protein in human breast carcinoma tissues, activation status of Rac1 still remains to be elucidated. " 12/08/2016 - "Results in this report indicate that Rac1 protein expression is increased in the breast cancer cells that survived HFR compared with parental cells. " 05/01/2015 - "Molecular data showed that EHD2 inhibited breast cancer migration and invasion probably by dampening the expression of Ras-related C3 botulinum toxin substrate 1 (Rac1). " 01/01/2020 - "Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein." 06/15/2000 - "In Northern and Western blot experiments both Rac1 RNA and Rac1 protein had a significantly higher expression in breast cancer tissues compared to normal breast tissue samples. "

Related Drugs and Biologics

1.	G-Protein-Coupled Receptor Kinase 2
2.	Proteins (Proteins, Gene)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Phosphotransferases (Kinase)
5.	Small Interfering RNA (siRNA)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Protein Tyrosine Phosphatases
8.	Amyloid beta-Peptides
9.	Enzymes
10.	Homer Scaffolding Proteins (Homer 1)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Transplantation