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Asperger Syndrome (Asperger's Syndrome)

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A childhood disorder predominately affecting boys and similar to autism (AUTISTIC DISORDER). It is characterized by severe, sustained, clinically significant impairment of social interaction, and restricted repetitive and stereotyped patterns of behavior. In contrast to autism, there are no clinically significant delays in language or cognitive development. (From DSM-IV)

Also Known As:

Asperger's Syndrome; Aspergers Syndrome; Asperger's Disorder; Asperger Disorder; Aspergers Disorder

Networked: 89 relevant articles (5 outcomes, 21 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Mental Disorders: 1866
- Mental Disorders Diagnosed in Childhood
  - Pervasive Child Development Disorders: 275
    - Asperger Syndrome: 89

Related Diseases

1.	Schizophrenia (Dementia Praecox)
2.	Autistic Disorder (Autism)
3.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
4.	Seizures (Seizure)
5.	Attention Deficit and Disruptive Behavior Disorders (Oppositional Defiant Disorder)

Experts

1.	Hollander, Eric: 4 articles (02/2007 - 01/2003)
2.	Hollander, E: 4 articles (07/2001 - 02/2000)
3.	Cartwright, C: 4 articles (07/2001 - 02/2000)
4.	Posey, David J: 3 articles (06/2009 - 10/2006)
5.	McDougle, Christopher J: 3 articles (06/2009 - 10/2006)
6.	Baron-Cohen, Simon: 3 articles (11/2008 - 08/2006)
7.	Wasserman, Stacey: 3 articles (02/2007 - 09/2004)
8.	Novotny, Sherie: 3 articles (10/2006 - 01/2003)
9.	Thompson, Michael: 2 articles (03/2010 - 03/2010)
10.	Thompson, Lynda: 2 articles (03/2010 - 03/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asperger Syndrome:

1.	Risperidone (Risperdal Consta)FDA LinkGeneric 12/01/2005 - "Open-label risperidone for Asperger's disorder: negative symptom spectrum response." 12/01/2005 - "We investigated whether risperidone, which is effective in treating the negative symptoms of schizophrenia, would improve such symptoms observed in Asperger's disorder in a prospective, open-label trial. " 07/01/2009 - "[Hyperprolactinemia in a child diagnosed with Asperger syndrome and hyperkinetic disorder treated with risperidone]" 02/01/2002 - "Charts for 106 children and adolescents (males n = 81 or 76.4%; females n = 25 or 23.6%), presenting with attention deficit and/or hyperactivity disorder (n = 49 or 46.2%), conduct disorder (n = 13 or 12.3%), oppositional-defiant disorder (n = 5 or 4.7%), behavioural problems not otherwise specified (n = 2 or 1.9%), autism (n = 8 or 7.5%), Asperger's syndrome (n = 8 or 7.5%), pervasive developmental disorder (PDD) not otherwise specified (n = 4 or 3.8%), anxiety (n = 6 or 5.7%), depression (n = 2 or 1.9%), dysthymia (n = 2 or 1.9%), schizophrenia (n = 4 or 3.8%), adjustment disorder (n = 1 or 0.9%) and obsessive-compulsive disorder (n = 2 or 1.9%) were reviewed retrospectively to determine the tolerability and potential efficacy of risperidone treatment for a variety of psychiatric disorders. " 01/01/1999 - "A 15-year-old adolescent male, with Asperger's disorder, Tourette's disorder and obsessive-compulsive disorder, on a tetracycline-risperidone-sertraline treatment regimen, had an acute exacerbation of motor and vocal tics. " Order ALL the reference details at left...
2.	tranilast (N 5')IBA 11/01/2003 - "Six of the seven family members with this mutation had OCD (n=5) or obsessive-compulsive personality disorder (n=1) and some also met diagnostic criteria for multiple other disorders (Asperger's syndrome, social phobia, anorexia nervosa, tic disorder and alcohol and other substance abuse/dependence). " 06/01/2001 - "Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperger's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine. " 02/01/2002 - "Charts for 106 children and adolescents (males n = 81 or 76.4%; females n = 25 or 23.6%), presenting with attention deficit and/or hyperactivity disorder (n = 49 or 46.2%), conduct disorder (n = 13 or 12.3%), oppositional-defiant disorder (n = 5 or 4.7%), behavioural problems not otherwise specified (n = 2 or 1.9%), autism (n = 8 or 7.5%), Asperger's syndrome (n = 8 or 7.5%), pervasive developmental disorder (PDD) not otherwise specified (n = 4 or 3.8%), anxiety (n = 6 or 5.7%), depression (n = 2 or 1.9%), dysthymia (n = 2 or 1.9%), schizophrenia (n = 4 or 3.8%), adjustment disorder (n = 1 or 0.9%) and obsessive-compulsive disorder (n = 2 or 1.9%) were reviewed retrospectively to determine the tolerability and potential efficacy of risperidone treatment for a variety of psychiatric disorders. " Order ALL the reference details at left...
3.	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 05/01/2006 - "RESULTS: People with Asperger's syndrome had a significant reduction in cortical 5-HT2A receptor binding in the total, anterior, and posterior cingulate; bilaterally in the frontal and superior temporal lobes; and in the left parietal lobe. " 05/01/2006 - "CONCLUSIONS: The authors' findings suggest that adults with Asperger's syndrome have abnormalities in cortical 5-HT2A receptor density and that this deficit may underlie some clinical symptoms." 05/01/2006 - "METHOD: The authors investigated cortical 5-HT2A receptor binding in eight adults with Asperger's syndrome and in 10 healthy comparison subjects with single photon emission computed tomography and the selective 5-HT2A receptor ligand 123I iodinated 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (123I-5-I-R91150). " 05/01/2006 - "Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study." Order ALL the reference details at left...
4.	MelatoninIBA 01/01/2003 - "In this open clinical trial, the effectiveness of melatonin was studied in a sample of 15 children with Asperger disorder (13 boys, 2 girls) aged 6-17 years using several questionnaires and actigraph measurements. " 01/01/2003 - "Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder." 01/01/2003 - "In conclusion, melatonin may provide an interesting new and well-tolerated treatment option for children with Asperger disorder suffering from chronic insomnia. " Order ALL the reference details at left...
5.	Carbon MonoxideIBA 03/01/2010 - "The present study aimed to provide clinical data regarding co-morbidity of psychiatric disorders in individuals diagnosed with Asperger's disorder (AD). " 03/01/2010 - "High rates of psychiatric co-morbidity in individuals with Asperger's disorder." 01/01/2007 - "This case report provides preliminary support for CO-OP as an intervention for children with Asperger's Syndrome that supports both skill acquisition and generalization and transfer of skills and strategies." 01/01/2007 - "Two case studies are reported that provide preliminary evidence of the effects of CO-OP on the everyday lives of two siblings (aged 9 years and 11 years) with Asperger's Syndrome. " 07/01/2002 - "Case history of co-morbid Asperger's syndrome and paraphilic behaviour." Order ALL the reference details at left...
6.	mofezolac (N 22)IBA 03/01/2007 - "Assessment groups were: Group 1: n = 81 children with Asperger Syndrome (AS) or high-functioning autism (HFA); Group 2: n = 22 children diagnosed PDD-NOS with average IQ; and Group 3: n = 372 randomly selected controls from primary and secondary schools. " 01/01/1996 - "This study examined group differences in language and pragmatic functions across sex-, age- and IQ-matched samples of Asperger syndrome (N = 22), high-functioning autism (N = 11), deficits in attention, motor control and perception (DAMP) (N = 11), and speech and language disorder (SLD) (N = 11) groups. " 02/01/1998 - "Forty-two adults with PDDs (autistic disorder, N = 22; Asperger's disorder, N = 6; and PDD not otherwise specified [NOS], N = 14) participated in a 12-week, open-label, systematic trial of sertraline. " Order ALL the reference details at left...
7.	nasIBA 03/01/1992 - "Evidence for alterations in season of birth of autistic children in 5 previous reports was tested using a national sample of 1435 autistic persons and those with Asperger's syndrome from the National Autistic Society (NAS) compared with 196 clinic patients from the Children's Department of Maudsely Hospital and their 121 sibling controls, both confined to births between 1947-80. " 12/01/2005 - "This study examines the outcome of a supported employment service (NAS Prospects) for adults with autism or Asperger syndrome (IQ 60+) over an 8 year period. " 08/01/2009 - "METHODS: Both parents of 54 subjects (46 males and 8 females; age range 4-28 years) with diagnosed PDD (43 with autistic disorder, 2 with childhood disintegrative disorder, 3 with Asperger Syndrome, 6 with pervasive development disorder NAS) were enrolled in the study. " Order ALL the reference details at left...
8.	olanzapine (Zyprexa)FDA Link 02/01/2006 - "An open trial of olanzapine in children and adolescents with Asperger Disorder." 10/01/2006 - "Eleven patients with a diagnosis of either autism, Asperger's syndrome, or PDD not otherwise specified (PDD-NOS) and aged 6-14 years were randomized into an 8-week double-blind, placebo-controlled, parallel treatment study with olanzapine. " Order ALL the reference details at left...
9.	Protons (Proton)IBA 10/01/2002 - "Asperger syndrome: a proton magnetic resonance spectroscopy study of brain." 01/01/2009 - "[Proton magnetic resonance spectroscopy in Asperger's syndrome: correlations with neuropsychological test scores]" 09/01/2007 - "Proton MR spectroscopy: higher right anterior cingulate N-acetylaspartate/choline ratio in Asperger syndrome compared with healthy controls." 11/01/2007 - "METHODS: N-acetylaspartate (NAA)/creatine (Cr) and choline/Cr ratios in the right medial temporal lobe (MTL), medial prefrontal cortex, and cerebellar vermis were measured in 38 individuals with ASD (mean age = 12.9 years), including 12 with autism, 15 with Asperger's Disorder, and 11 with pervasive developmental disorder not otherwise specified (PDD-NOS), and 16 matched healthy control subjects (mean age = 11.5 years) with proton magnetic resonance spectroscopy. " Order ALL the reference details at left...
10.	Aminosalicylic Acid (PAS)FDA Link 02/01/2009 - "In the present study, we investigated mind reading abilities in a group of adults with Asperger Syndrome (AS) by using the faux pas task, an advanced test of theory of mind (Baron-Cohen et al. (1999). " 03/01/2010 - "The HFA and Asperger syndrome groups were impaired in performance of the Strange stories test and the Faux-pas test and reported more theory of mind problems than the neurotypical adults. " 02/01/2009 - "Faux pas detection and intentional action in Asperger Syndrome. " 09/01/1998 - "Bilateral orbito-frontal lesion patients performed similarly to individuals with Asperger"s syndrome, performing well on simpler tests and showing deficits on tasks requiring more subtle social reasoning, such as the ability to recognize a faux pas. " 10/01/1999 - "Recognition of faux pas by normally developing children and children with Asperger syndrome or high-functioning autism." Order ALL the reference details at left...

Therapies and Procedures

1.	Vagus Nerve Stimulation 03/01/2007 - "We describe the efficacy of vagus nerve stimulation therapy in reducing seizure severity as well as improving the behavioral components of his Asperger syndrome. " 03/01/2007 - "Effects of vagus nerve stimulation in a patient with temporal lobe epilepsy and Asperger syndrome: case report and review of the literature." Order ALL the reference details at left...
2.	Psychology Biofeedback (Biofeedback) 03/01/2010 - "This paper summarizes data from a review of neurofeedback (NFB) training with 150 clients with Asperger's Syndrome (AS) and 9 clients with Autistic Spectrum Disorder (ASD) seen over a 15 year period (1993-2008) in a clinical setting. " 03/01/2010 - "Neurofeedback outcomes in clients with Asperger's syndrome." 03/01/2010 - "(A second paper, Outcomes using EEG Biofeedback Training in Clients with Asperger's Syndrome, summarizes clinical outcomes obtained with more than 150 clients.) Patterns seen with QEEG assessment are then presented. " 03/01/2010 - "Functional neuroanatomy and the rationale for using EEG biofeedback for clients with Asperger's syndrome." 06/01/2005 - "This article reports the pilot study of electroencephalogram (EEG) biofeedback to improve focusing and decrease anxiety in 10 adolescent boys diagnosed with Asperger's syndrome attending a therapeutic day school. " Order ALL the reference details at left...
3.	Therapeutics 12/01/2004 - "[Considerations about echolalia in children with Asperger's syndrome: proposing an approach for language therapeutics]" Order ALL the reference details at left...
4.	Play Therapy (Therapy, Play) 11/01/2009 - "I will discuss a case of my own with Asperger's syndrome in which union and separation in the play therapy occurred simultaneously. " Order ALL the reference details at left...
5.	Language Therapy (Language Training) 10/01/2008 - "METHOD: twenty subjects with ages between four and twelve years, diagnosed with autism or asperger syndrome (DSM-IV-TR, 2002) by a multidisciplinary team, with no associated disorders, and who were enrolled in language therapy for at least six months were assessed. " Order ALL the reference details at left...

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