Asperger Syndrome (Asperger's Syndrome)

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66 relevant articles (4 outcomes, 16 trials/studies) found for this Disease

Description: A childhood disorder predominately affecting boys and similar to autism (AUTISTIC DISORDER). It is characterized by severe, sustained, clinically significant impairment of social interaction, and restricted repetitive and stereotyped patterns of behavior. In contrast to autism, there are no clinically significant delays in language or cognitive development. (From DSM-IV)

Also Known As:

Asperger's Syndrome; Aspergers Syndrome; Asperger's Disorder; Asperger Disorder; Aspergers Disorder

Relationship Network

Disease Context: Research Results

Mental Disorders: 1709

Mental Disorders Diagnosed in Childhood

Pervasive Child Development Disorders: 3

Asperger Syndrome: 66

Related Diseases

1.	Schizophrenia (Dementia Praecox)
2.	Autistic Disorder (Autism)
3.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
4.	Attention Deficit and Disruptive Behavior Disorders (Oppositional Defiant Disorder)
5.	Conduct Disorder

Experts

1.	Daly, Eileen: 2 articles (05/2006 - 10/2002)
2.	Murphy, Declan G M: 2 articles (05/2006 - 10/2002)
3.	Schmitz, Nicole: 2 articles (05/2006 - 10/2002)
4.	Nieminen-von Wendt, Taina: 2 articles (06/2005 - 01/2003)
5.	von Wendt, Lennart: 2 articles (06/2005 - 01/2003)
6.	Vanhala, Raija: 2 articles (04/2004 - 01/2003)
7.	Oktem, F: 1 article (09/2007)
8.	Devrimci-Ozguven, H: 1 article (09/2007)
9.	Munir, K M: 1 article (09/2007)
10.	Baskak, B: 1 article (09/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asperger Syndrome:

1.	Risperidone (Risperdal Consta)FDA Link 12/01/2005 - "Open-label risperidone for Asperger's disorder: negative symptom spectrum response." 12/01/2005 - "We investigated whether risperidone, which is effective in treating the negative symptoms of schizophrenia, would improve such symptoms observed in Asperger's disorder in a prospective, open-label trial" 02/01/2002 - "Charts for 106 children and adolescents (males n = 81 or 76.4%; females n = 25 or 23.6%), presenting with attention deficit and/or hyperactivity disorder (n = 49 or 46.2%), conduct disorder (n = 13 or 12.3%), oppositional-defiant disorder (n = 5 or 4.7%), behavioural problems not otherwise specified (n = 2 or 1.9%), autism (n = 8 or 7.5%), Asperger's syndrome (n = 8 or 7.5%), pervasive developmental disorder (PDD) not otherwise specified (n = 4 or 3.8%), anxiety (n = 6 or 5.7%), depression (n = 2 or 1.9%), dysthymia (n = 2 or 1.9%), schizophrenia (n = 4 or 3.8%), adjustment disorder (n = 1 or 0.9%) and obsessive-compulsive disorder (n = 2 or 1.9%) were reviewed retrospectively to determine the tolerability and potential efficacy of risperidone treatment for a variety of psychiatric disorders" 01/01/1999 - "A 15-year-old adolescent male, with Asperger's disorder, Tourette's disorder and obsessive-compulsive disorder, on a tetracycline-risperidone-sertraline treatment regimen, had an acute exacerbation of motor and vocal tics" Order ALL the reference details at left...
2.	tranilast (N 5')IBA 11/01/2003 - "Six of the seven family members with this mutation had OCD (n=5) or obsessive-compulsive personality disorder (n=1) and some also met diagnostic criteria for multiple other disorders (Asperger's syndrome, social phobia, anorexia nervosa, tic disorder and alcohol and other substance abuse/dependence)" 06/01/2001 - "Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperger's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine" 02/01/2002 - "Charts for 106 children and adolescents (males n = 81 or 76.4%; females n = 25 or 23.6%), presenting with attention deficit and/or hyperactivity disorder (n = 49 or 46.2%), conduct disorder (n = 13 or 12.3%), oppositional-defiant disorder (n = 5 or 4.7%), behavioural problems not otherwise specified (n = 2 or 1.9%), autism (n = 8 or 7.5%), Asperger's syndrome (n = 8 or 7.5%), pervasive developmental disorder (PDD) not otherwise specified (n = 4 or 3.8%), anxiety (n = 6 or 5.7%), depression (n = 2 or 1.9%), dysthymia (n = 2 or 1.9%), schizophrenia (n = 4 or 3.8%), adjustment disorder (n = 1 or 0.9%) and obsessive-compulsive disorder (n = 2 or 1.9%) were reviewed retrospectively to determine the tolerability and potential efficacy of risperidone treatment for a variety of psychiatric disorders" Order ALL the reference details at left...
3.	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 05/01/2006 - "RESULTS: People with Asperger's syndrome had a significant reduction in cortical 5-HT2A receptor binding in the total, anterior, and posterior cingulate; bilaterally in the frontal and superior temporal lobes; and in the left parietal lobe" 05/01/2006 - "CONCLUSIONS: The authors' findings suggest that adults with Asperger's syndrome have abnormalities in cortical 5-HT2A receptor density and that this deficit may underlie some clinical symptoms." 05/01/2006 - "METHOD: The authors investigated cortical 5-HT2A receptor binding in eight adults with Asperger's syndrome and in 10 healthy comparison subjects with single photon emission computed tomography and the selective 5-HT2A receptor ligand 123I iodinated 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (123I-5-I-R91150)" 05/01/2006 - "Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study." Order ALL the reference details at left...
4.	MelatoninIBA 01/01/2003 - "In this open clinical trial, the effectiveness of melatonin was studied in a sample of 15 children with Asperger disorder (13 boys, 2 girls) aged 6-17 years using several questionnaires and actigraph measurements" 01/01/2003 - "Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder." 01/01/2003 - "In conclusion, melatonin may provide an interesting new and well-tolerated treatment option for children with Asperger disorder suffering from chronic insomnia" Order ALL the reference details at left...
5.	mofezolac (N 22)IBA 03/01/2007 - "Assessment groups were: Group 1: n = 81 children with Asperger Syndrome (AS) or high-functioning autism (HFA); Group 2: n = 22 children diagnosed PDD-NOS with average IQ; and Group 3: n = 372 randomly selected controls from primary and secondary schools" 01/01/1996 - "This study examined group differences in language and pragmatic functions across sex-, age- and IQ-matched samples of Asperger syndrome (N = 22), high-functioning autism (N = 11), deficits in attention, motor control and perception (DAMP) (N = 11), and speech and language disorder (SLD) (N = 11) groups" 02/01/1998 - "Forty-two adults with PDDs (autistic disorder, N = 22; Asperger's disorder, N = 6; and PDD not otherwise specified [NOS], N = 14) participated in a 12-week, open-label, systematic trial of sertraline" Order ALL the reference details at left...
6.	olanzapine (Zyprexa)FDA Link 02/01/2006 - "An open trial of olanzapine in children and adolescents with Asperger Disorder." 10/01/2006 - "Eleven patients with a diagnosis of either autism, Asperger's syndrome, or PDD not otherwise specified (PDD-NOS) and aged 6-14 years were randomized into an 8-week double-blind, placebo-controlled, parallel treatment study with olanzapine" Order ALL the reference details at left...
7.	Protons (Proton)IBA 10/01/2002 - "Asperger syndrome: a proton magnetic resonance spectroscopy study of brain." 09/01/2007 - "Proton MR spectroscopy: higher right anterior cingulate N-acetylaspartate/choline ratio in Asperger syndrome compared with healthy controls." 11/01/2007 - "METHODS: N-acetylaspartate (NAA)/creatine (Cr) and choline/Cr ratios in the right medial temporal lobe (MTL), medial prefrontal cortex, and cerebellar vermis were measured in 38 individuals with ASD (mean age = 12.9 years), including 12 with autism, 15 with Asperger's Disorder, and 11 with pervasive developmental disorder not otherwise specified (PDD-NOS), and 16 matched healthy control subjects (mean age = 11.5 years) with proton magnetic resonance spectroscopy" Order ALL the reference details at left...
8.	Sertraline (Zoloft)FDA LinkGeneric 02/01/1998 - "Forty-two adults with PDDs (autistic disorder, N = 22; Asperger's disorder, N = 6; and PDD not otherwise specified [NOS], N = 14) participated in a 12-week, open-label, systematic trial of sertraline" 01/01/1999 - "A 15-year-old adolescent male, with Asperger's disorder, Tourette's disorder and obsessive-compulsive disorder, on a tetracycline-risperidone-sertraline treatment regimen, had an acute exacerbation of motor and vocal tics" Order ALL the reference details at left...
9.	Serotonin (5 Hydroxytryptamine)IBA 03/01/2001 - "Alleviation of sleep disturbance and repetitive behavior by a selective serotonin re-uptake inhibitor in a boy with Asperger's syndrome." 05/01/2006 - "Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study." Order ALL the reference details at left...
10.	Oxytocin (Pitocin)FDA LinkGeneric 01/01/2003 - "This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges" 02/15/2007 - "METHODS: Oxytocin and placebo challenges were administered to 15 adult subjects diagnosed with autism or Asperger's disorder, and comprehension of affective speech (happy, indifferent, angry, and sad) in neutral content sentences was tested" Order ALL the reference details at left...

Therapies and Procedures

1.	Therapeutics 12/01/2004 - "Considerations about echolalia in children with Asperger's syndrome: proposing an approach for language therapeutics]" Order ALL the reference details at left...
2.	Biofeedback (Psychology) (Biofeedback) 06/01/2005 - "This article reports the pilot study of electroencephalogram (EEG) biofeedback to improve focusing and decrease anxiety in 10 adolescent boys diagnosed with Asperger's syndrome attending a therapeutic day school" 06/01/2005 - "Effects of electroencephalogram biofeedback with Asperger's syndrome." Order ALL the reference details at left...

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