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Asperger Syndrome (Asperger's Syndrome)

A childhood disorder predominately affecting boys and similar to autism (AUTISTIC DISORDER). It is characterized by severe, sustained, clinically significant impairment of social interaction, and restricted repetitive and stereotyped patterns of behavior. In contrast to autism, there are no clinically significant delays in language or cognitive development. (From DSM-IV)
Also Known As:
Asperger's Syndrome; Aspergers Syndrome; Asperger's Disorder; Asperger Disorder; Aspergers Disorder
Networked: 141 relevant articles (8 outcomes, 39 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Autistic Disorder (Autism)
2. Schizophrenia (Dementia Praecox)
3. Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
4. Seizures (Seizure)
5. Attention Deficit and Disruptive Behavior Disorders (Oppositional Defiant Disorder)

Experts

1. McDougle, Christopher J: 6 articles (08/2012 - 10/2006)
2. Baron-Cohen, Simon: 5 articles (01/2014 - 08/2006)
3. Posey, David J: 5 articles (08/2012 - 10/2006)
4. Hollander, Eric: 5 articles (12/2011 - 01/2003)
5. Wasserman, Stacey: 4 articles (12/2011 - 09/2004)
6. Hollander, E: 4 articles (07/2001 - 02/2000)
7. Cartwright, C: 4 articles (07/2001 - 02/2000)
8. Rinehart, Nicole J: 3 articles (04/2015 - 04/2010)
9. Tonge, Bruce J: 3 articles (04/2015 - 04/2010)
10. Gillberg, Christopher: 3 articles (07/2014 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asperger Syndrome:
1. Risperidone (Risperdal Consta)FDA LinkGeneric
12/01/2005 - "Open-label risperidone for Asperger's disorder: negative symptom spectrum response."
12/01/2005 - "We investigated whether risperidone, which is effective in treating the negative symptoms of schizophrenia, would improve such symptoms observed in Asperger's disorder in a prospective, open-label trial. "
10/01/2014 - "An observational cohort study of 40 children (34 males, six females; median age 7y range 3-18y) with autistic disorder, pervasive developmental disorder not otherwise specified, or Asperger syndrome diagnosed using the Autism Diagnostic Interview-Revised and treated with risperidone for at least 3 months. "
07/01/2009 - "[Hyperprolactinemia in a child diagnosed with Asperger syndrome and hyperkinetic disorder treated with risperidone]."
02/01/2002 - "Charts for 106 children and adolescents (males n = 81 or 76.4%; females n = 25 or 23.6%), presenting with attention deficit and/or hyperactivity disorder (n = 49 or 46.2%), conduct disorder (n = 13 or 12.3%), oppositional-defiant disorder (n = 5 or 4.7%), behavioural problems not otherwise specified (n = 2 or 1.9%), autism (n = 8 or 7.5%), Asperger's syndrome (n = 8 or 7.5%), pervasive developmental disorder (PDD) not otherwise specified (n = 4 or 3.8%), anxiety (n = 6 or 5.7%), depression (n = 2 or 1.9%), dysthymia (n = 2 or 1.9%), schizophrenia (n = 4 or 3.8%), adjustment disorder (n = 1 or 0.9%) and obsessive-compulsive disorder (n = 2 or 1.9%) were reviewed retrospectively to determine the tolerability and potential efficacy of risperidone treatment for a variety of psychiatric disorders. "
2. aripiprazole (Abilify)FDA Link
3. tranilast (N 5')IBA
03/01/2011 - "The sample was composed of 11 children diagnosed with Autism (n=6) and Asperger syndrome (n=5) by a multidisciplinary team, that attended specialized speech-language pathology therapy at the institution were the study was carried out. "
11/01/2003 - "Six of the seven family members with this mutation had OCD (n=5) or obsessive-compulsive personality disorder (n=1) and some also met diagnostic criteria for multiple other disorders (Asperger's syndrome, social phobia, anorexia nervosa, tic disorder and alcohol and other substance abuse/dependence). "
06/01/2001 - "Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperger's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine. "
02/01/2002 - "Charts for 106 children and adolescents (males n = 81 or 76.4%; females n = 25 or 23.6%), presenting with attention deficit and/or hyperactivity disorder (n = 49 or 46.2%), conduct disorder (n = 13 or 12.3%), oppositional-defiant disorder (n = 5 or 4.7%), behavioural problems not otherwise specified (n = 2 or 1.9%), autism (n = 8 or 7.5%), Asperger's syndrome (n = 8 or 7.5%), pervasive developmental disorder (PDD) not otherwise specified (n = 4 or 3.8%), anxiety (n = 6 or 5.7%), depression (n = 2 or 1.9%), dysthymia (n = 2 or 1.9%), schizophrenia (n = 4 or 3.8%), adjustment disorder (n = 1 or 0.9%) and obsessive-compulsive disorder (n = 2 or 1.9%) were reviewed retrospectively to determine the tolerability and potential efficacy of risperidone treatment for a variety of psychiatric disorders. "
4. 5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA
5. MelatoninIBA
6. ZincIBA
7. CopperIBA
8. Diazepam (Valium)FDA LinkGeneric
9. Oxytocin (Pitocin)FDA LinkGeneric
10. Protons (Proton)IBA

Therapies and Procedures

1. Vagus Nerve Stimulation
2. Neurofeedback
3. Rehabilitation
4. Psychology Biofeedback (Biofeedback)
5. Acupressure (Shiatsu)