|4.||Herpes Genitalis (Genital Herpes)
|5.||Encephalitis (Encephalitis, Rasmussen)
|1.||Shoji, Hiroshi: 5 articles (09/2012 - 02/2002)|
|2.||Dalmau, Josep: 4 articles (03/2015 - 12/2012)|
|3.||Jackson, Alan C: 3 articles (09/2015 - 06/2006)|
|4.||Studahl, Marie: 3 articles (09/2015 - 04/2009)|
|5.||Gnann, John W: 3 articles (09/2015 - 02/2002)|
|6.||Whitley, Richard J: 3 articles (09/2015 - 02/2002)|
|7.||Leypoldt, Frank: 3 articles (03/2015 - 07/2013)|
|8.||Armangue, Thaís: 3 articles (03/2015 - 07/2013)|
|9.||Hu, Shuxian: 3 articles (10/2013 - 05/2008)|
|10.||de Vries, Erik F J: 3 articles (03/2012 - 11/2009)|
|1.||Acyclovir (Aciclovir)FDA LinkGeneric
08/01/2013 - "The effective cure rate of acyclovir emphasizes the importance of an early diagnosis and treatment in reducing the considerable mortality and the morbidity in patients with Herpes Simplex Encephalitis (HSE). "
05/01/2012 - "In the 1980s the outcome of patients with herpes simplex encephalitis was shown to be dramatically improved with aciclovir treatment. "
04/01/2012 - "In the 1980s the outcome of patients with herpes simplex encephalitis was shown to be dramatically improved with aciclovir treatment. "
12/01/2011 - "Although a high proportion remains unexplained, the most frequently identified cause in all countries was always herpes simplex virus type 1. The generalisation of acyclovir dramatically improved the survival rate of herpes simplex encephalitis patients. "
09/01/2015 - "Despite the proven efficacy of acyclovir (ACV) therapy, herpes simplex encephalitis (HSE) continues to cause substantial morbidity and mortality. "
|2.||Vidarabine (Vira-A)FDA Link
01/01/2009 - "Many marine natural products have successfully advanced to the late stages of clinical trials, as for example ara-A (vidarabine), an anti-viral drug used against the herpes simplex encephalitis virus. "
02/05/1981 - "To learn more about the treatment of herpes simplex encephalitis with vidarabine, we conducted an uncontrolled study of 132 patients referred to 22 hospitals because of suspected disease. "
02/01/1983 - "Recurrent herpes simplex encephalitis: recovery of virus after Ara-A treatment."
09/01/1982 - "[Early adenine arabinoside therapy in herpes simplex encephalitis (HSE)]."
04/01/1982 - "Herpes simplex encephalitis: poor outcome despite adenine arabinoside therapy."
09/01/2009 - "Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection."
02/01/2008 - "Ten patients were diagnosed with herpes simplex CNS disease, 9 with herpes simplex encephalitis and 1 with neonatal herpes. "
09/29/1984 - "Herpes simplex encephalitis, neonatal herpes infections, chronic hepatitis B."
02/01/2010 - "Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are important human pathogens that cause a variety of diseases from mild skin diseases such as herpes labialis and herpes genitalis to life-threatening diseases such as herpes encephalitis and neonatal herpes. "
10/01/1998 - "These viruses cause a variety of clinical illnesses including genital herpes, oral-facial infections, cutaneous infections, ocular infections, neonatal herpes, herpes encephalitis, disseminated infection, and erythema multiforme. "
|4.||Antiviral Agents (Antivirals)IBA
07/01/1996 - "In addition, since the introduction of antiviral drugs in the treatment of herpes encephalitis in its initial stages, the prognosis of the disease has improved. "
01/01/2009 - "Effect of combinations of antiviral drugs on herpes simplex encephalitis."
09/01/2008 - "The morbidity and mortality of herpes simplex encephalitis have decreased since the 1980s with the use of antivirals, but have remained stable in the last couple of years. "
02/01/2002 - "In recent years, advances in the diagnosis and treatment of herpes simplex encephalitis (HSE) have been achieved due to the prevalence of antiviral drugs and the introduction of the polymerase chain reaction (PCR) to test the cerebrospinal fluid. "
03/01/2000 - "The higher oral bioavailability of newer antiviral agents allows part of the extended treatment period of patients with herpes simplex encephalitis to be carried out as an ambulatory oral regimen."
|5.||DNA (Deoxyribonucleic Acid)IBA
08/01/1998 - "One patient had a twofold increase in HSV DNA levels after 1 week of therapy and died on day 8. The application of this assay may be helpful in establishing the prognosis and in the monitoring of patients with herpes simplex encephalitis."
12/01/2000 - "The aim of this study was to analyze the diagnosis found in a series of patients in which the diagnosis of Herpes simplex encephalitis (HSE) was ruled out by a negative polymerase chain reaction (PCR) result for HSV DNA in cerebrospinal fluid (CSF) samples. "
01/01/1999 - "In a two-centre study, the routine DNA preparation and PCR amplification protocols were compared for herpes simplex virus (HSV) detection in cerebrospinal fluids (CSFs) of 43 patients with suspected herpes simplex encephalitis (HSE). "
01/01/1999 - "Two-centre study comparing DNA preparation and PCR amplification protocols for herpes simplex virus detection in cerebrospinal fluids of patients with suspected herpes simplex encephalitis."
02/01/1997 - "Previous studies have shown the diagnostic utility of qualitative detection of herpes simplex virus (HSV) DNA by the polymerase chain reaction (PCR) in cerebrospinal fluid samples (CSF) from patients with herpes simplex encephalitis (HSE). "
06/01/2013 - "However, the increasing use of polymerase chain reaction to detect viral DNA in the cerebrospinal fluid has allowed the expansion of the spectrum of radiologic findings possibly associated with herpes simplex encephalitis. "
08/01/2009 - "Prognostic value of intrathecal antibody production and DNA viral load in cerebrospinal fluid of patients with herpes simplex encephalitis."
06/01/1998 - "Chronic active destructive herpes simplex encephalitis with recovery of viral DNA 12 years after disease onset."
06/25/1994 - "Herpes simplex encephalitis may be diagnosed using modern laboratory techniques for detection of viral DNA without the need for brain biopsy. "
10/01/1991 - "Autopsy neuropathological findings in 'burnt out' herpes simplex encephalitis and use of the polymerase chain reaction to detect viral DNA."
|7.||valacyclovir (valaciclovir)FDA LinkGeneric
09/01/2015 - "Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy."
09/01/2015 - "Editorial Commentary: Failure of Adjunctive Valacyclovir to Improve Outcomes in Herpes Simplex Encephalitis."
07/01/2011 - "Valacyclovir for herpes simplex encephalitis."
03/01/2000 - "Use of oral valaciclovir in a 12-year-old boy with herpes simplex encephalitis."
05/01/2006 - "Of these, 9 were subjects with neuropsychiatric signs and symptoms and 12 were asymptomatic subjects, including 10 subjects from a valaciclovir multiple sclerosis trial and 2 subjects with recurrent herpes encephalitis. "
09/01/1983 - "The mortality of herpes simplex encephalitis and neonatal herpes simplex virus infections has been reduced to 34 and 30%, respectively, a decrease of approximately 10% for each disease. "
09/01/1983 - "Herpes simplex encephalitis and neonatal herpes simplex virus infections are important consequences of herpes simplex virus infections of humans. "
08/10/1980 - "[Herpes simplex encephalitis and neonatal herpes simplex infections]."
09/19/1981 - "A sensitive and specific radioimmunosorbent assay for serum and cerebrospinal fluid (CSF) IgG antibodies against Herpesvirus simplex has been evaluated as an early diagnostic test for herpes encephalitis. "
09/01/1983 - "The NIAID Collaborative Antiviral Study Group has been able to demonstrate that vidarabine therapy decreases the mortality and improves morbidity for both herpes simplex encephalitis and neonatal herpes simplex virus infections. "
01/01/1986 - "For rapid diagnosis of Herpes encephalitis in rabbits, demonstration of herpes simplex virus antigens in CSF by means of an indirect ELISA is superior to the other methods investigated."
07/01/1999 - "Twenty one cerebrospinal fluid (CSF)/brain tissue (16 CSF and 5 brain tissue) from patients clinically suspected of herpes simplex encephalitis (HSE) were collected during one year period and was subjected for the detection of HSV type I and type II antigen by direct Immunofluorescence (DIF). "
09/01/1991 - "There are no typical clinical signs for herpes encephalitis, CT, NMR, EEG findings as well as antigen and antibody-tests do naturally take their time. "
11/01/1989 - "[Detection of antigen and antibody in herpes simplex encephalitis]."
03/01/1989 - "Experimental murine herpes simplex encephalitis: immunohistochemical detection of virus antigens."
|10.||Cytarabine (Cytosar-U)FDA LinkGeneric
08/07/1976 - "This report supports the observation by some authors that cytosine arabinoside may be of value in the treatment of herpes simplex encephalitis."
03/01/1973 - "Cytosine arabinoside therapy for herpes simplex encephalitis--clinical experience with six patients."
08/01/1972 - "Cytarabine treatment of herpes simplex encephalitis."
08/07/1976 - "Herpes simplex encephalitis: treatment with surgical decompression and cytosine arabinoside."
09/01/1978 - "Efficacy of adenine arabinoside (Ara-A) and cytarabine (Ara-C) in the treatment herpes encephalitis in animal model."
08/01/2015 - "Unusual Clinical Presentation and Role of Decompressive Craniectomy in Herpes Simplex Encephalitis."
07/01/2008 - "A case of herpes simplex encephalitis revealed by decompressive craniectomy."
12/01/2003 - "There are anecdotal reports of patients with refractory intracranial hypertension due to herpetic encephalitis that were treated with decompressive craniectomy with good results. "
08/01/2015 - "We describe improved outcome of decompressive craniectomy in a 7-year-old boy with severe herpes simplex encephalitis and medically refractory intracranial hypertension, along with a brief review of the literature. "
07/01/2009 - "[Late refractory intracranial hypertension treated by decompressive craniectomy in severe herpetic encephalitis]."
|2.||Intensive Care (Surgical Intensive Care)
01/01/1985 - "The frequency of HSV infection in intensive care patients and the use of Klapper's index for the diagnosis of herpes encephalitis in these patients are then discussed."
01/09/1988 - "The prognosis of herpes simplex encephalitis has improved owing to advances in intensive care and to the advent of antiviral treatments, notably acyclovir the effectiveness of which has been demonstrated by several therapeutic trials. "
07/01/1986 - "Problems and developments of antiviral chemotherapy can be demonstrated with herpes encephalitis: optimum medical intensive care and early acyclovir therapy reduce lethality from approx. "
12/01/1990 - "Sphenoidal electrodes study of the internal face of the temporal lobe could record such activity in herpes encephalitis. "
12/01/1990 - "Faced with uncertain diagnosis of herpes encephalitis, it may be useful to insert sphenoidal electrodes to record deep periodic discharges, not seen on surface electrodes, in order to confirm the diagnosis."
12/01/1990 - "Sphenoidal electrodes were inserted in 4 patients known to have herpes encephalitis. "
12/01/1990 - "[Value of sphenoidal electrodes in the EEG diagnosis of herpes encephalitis]."