|1.||Pham, Christine T N: 6 articles (03/2012 - 02/2002)|
|2.||Wolters, Paul J: 4 articles (07/2014 - 02/2004)|
|3.||Caughey, George H: 3 articles (07/2014 - 02/2004)|
|4.||Zhang, Y: 3 articles (06/2002 - 02/2000)|
|5.||Hart, T C: 3 articles (06/2002 - 02/2000)|
|6.||Hart, P S: 3 articles (06/2002 - 02/2000)|
|7.||Turk, Dusan: 2 articles (04/2014 - 03/2004)|
|8.||Chandran, Kartik: 2 articles (01/2014 - 03/2013)|
|9.||Lima, Heriberto: 2 articles (01/2014 - 03/2013)|
|10.||Guentsch, Arndt: 2 articles (01/2014 - 09/2012)|
|1.||Asthma (Bronchial Asthma)
06/26/2002 - "These results indicate that the variant may play a role in regulating the biological activities of cathepsin C, involved in the pathogenesis of bronchial asthma."
01/01/2007 - "The few studies that have been done have identified many novel candidate genes and pathways in asthma pathogenesis, including ALOX15 and serine proteinase inhibitors cathepsin C and G. "
03/01/2008 - "In this study, we show that the absence of dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease found in neutrophils, dampens the acute inflammatory response and the subsequent mucous cell metaplasia that accompanies the asthma phenotype induced by Sendai virus infection. "
10/01/2010 - "Genetic studies have shown that mutations in the major gene locus of chromosome 11q14 with loss of function of cathepsin C gene are responsible for Papillon-Lefevre syndrome. "
01/01/2014 - "Papillon-Lefevre syndrome (PLS) without cathepsin C mutation: A rare early onset partially penetrant variant of PLS."
10/01/2010 - "The exact cause for periodontal destruction in patients with Papillon-Lefevre syndrome is not known but it is thought to be due to defect in neutrophil function, immune suppression and mutations in cathepsin C gene."
08/01/2010 - "A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome."
12/30/2009 - "Papillon-Lefevre syndrome is a rare autosomal recessive disorder caused by cathepsin C gene mutation leading to the deficiency of cathepsin C enzymatic activity. "
01/01/2014 - "Collectively, these findings imply that the lack of protease 3 activation by dysfunctional cathepsin C in PLS patients leads to the deficit of antimicrobial and immunomodulatory functions of LL-37 in the gingiva, allowing for infection with A. "
05/01/2011 - "Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function."
03/01/2008 - "Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infection."
02/16/2007 - "Cathepsin C inhibitors also limited the in vivo infection of T. "
12/01/2006 - "Increased susceptibility to infection has been reported among individuals with the cathepsin C (CTSC) gene mutation. "
|4.||Periodontal Diseases (Periodontal Disease)
01/01/2014 - "However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases."
12/01/1999 - "A more complete understanding of the functional physiology of cathepsin C carries significant implications for understanding normal and abnormal skin development and periodontal disease susceptibility."
02/01/2001 - "Papillon-Lefèvre syndrome (PLS) has recently been shown to be caused by mutations in the cathepsin C gene resulting in periodontal disease and palmoplantar keratosis. "
12/01/1999 - "Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis."
01/01/2014 - "The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases. "
|5.||Abdominal Aortic Aneurysm
11/01/2007 - "Evaluation of: Pagano MB, Bartoli MA, Ennis TL et al.: Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms. "
02/20/2007 - "Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms."
11/01/2007 - "Role of cathepsin C in elastase-induced mouse abdominal aortic aneurysms."
11/01/2007 - "In this study, the authors used dipeptidyl peptidase I (DPPI) gene-targeted mice and an aortic elastase perfusion-induced mouse abdominal aortic aneurysm (AAA) model to examine the role of DPPI, also termed cathepsin C, in the development of AAA. "
|1.||Cysteine Proteases (Cysteine Protease)
|4.||Proteins (Proteins, Gene)
|6.||dipeptidyl peptidase II
|7.||Serine Proteases (Serine Protease)
|8.||Myeloblastin (Proteinase 3)
|10.||Peptide Hydrolases (Proteases)