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Matrix Metalloproteinase 1 (Interstitial Collagenase)

A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.
Also Known As:
Interstitial Collagenase; MMP-1 Metalloproteinase; MMP1 Metalloproteinase; Matrix Metalloproteinase-1; Pro-Matrix Metalloproteinase-1; Promatrixmetalloproteinase-1; proMMP-1; MMP 1 Metalloproteinase; Metalloproteinase 1, Matrix; Metalloproteinase, MMP-1; Metalloproteinase, MMP1; Metalloproteinase-1, Pro-Matrix; Pro Matrix Metalloproteinase 1; Promatrixmetalloproteinase 1; proMMP 1
Networked: 887 relevant articles (7 outcomes, 110 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Brinckerhoff, Constance E: 12 articles (04/2013 - 01/2002)
2. D'Armiento, Jeanine: 7 articles (08/2015 - 01/2003)
3. Ray, Bimal K: 6 articles (12/2005 - 01/2003)
4. Ray, Alpana: 6 articles (12/2005 - 01/2003)
5. Friedland, Jon S: 5 articles (08/2015 - 10/2005)
6. Scully, Sean P: 5 articles (06/2012 - 11/2003)
7. Sorsa, Timo: 5 articles (12/2011 - 01/2007)
8. Ghahary, Aziz: 4 articles (11/2015 - 07/2010)
9. D'Armiento, Jeanine M: 4 articles (02/2015 - 04/2008)
10. Orbe, Josune: 4 articles (02/2015 - 04/2006)

Related Diseases

1. Fibrosis (Cirrhosis)
2. Liver Cirrhosis (Hepatic Cirrhosis)
3. Hypertension (High Blood Pressure)
08/01/2008 - "Longitudinal strain and torsion assessed by two-dimensional speckle tracking correlate with the serum level of tissue inhibitor of matrix metalloproteinase-1, a marker of myocardial fibrosis, in patients with hypertension."
11/01/2012 - "This study aimed to explore the efficacy of simvastatin on haemodynamic changes, pulmonary vascular remodelling and expression of matrix metalloproteinase-1 and -9 (MMP-1,9) in a carotid artery-jugular vein (CA-JV) shunt pulmonary artery hypertension (PAH) model in rats. "
01/01/2009 - "Aim of the study--investigation of dynamics of levels of serum markers of myocardial fibrosis matrix metalloproteinase-1 (MMP-1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1)--at the background of 3 months hypotensive therapy in 39 patients with arterial hypertension and paroxysmal form of atrial fibrillation. "
08/11/1998 - "We measured serum concentrations of carboxy-terminal telopeptide of collagen type I (CITP) as a marker of extracellular collagen type I degradation, of total matrix metalloproteinase-1 (MMP-1), or collagenase, of total tissue inhibitor of metalloproteinases 1 (TIMP-1), and of MMP-1/TIMP-1 complex in 37 patients with never-treated essential hypertension and in 23 normotensive control subjects. "
01/01/2007 - "Aim of the study was to investigate interrelationship between serum markers of myocardial fibrosis: matrix metalloproteinase -1 (MMP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1) and parameters of echocardiography in patients with arterial hypertension (AH) and paroxysmal form of atrial fibrillation (n=39). "
4. Cicatrix (Scar)
5. Hyperemia

Related Drugs and Biologics

1. Matrix Metalloproteinase 1 (Interstitial Collagenase)
2. Simvastatin (Zocor)
3. Collagen
4. Matrix Metalloproteinase 9 (Gelatinase B)
5. Transforming Growth Factors (Transforming Growth Factor)
6. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7. Matrix Metalloproteinase 13
8. C-Reactive Protein
9. Tissue Extracts
10. Type 2 Angiotensin Receptor

Related Therapies and Procedures

1. Transplants (Transplant)
2. Transplantation (Transplant Recipients)
3. Heterologous Transplantation (Xenotransplantation)
4. Microspheres (Microsphere)
5. Ligation