Matrix Metalloproteinase 2 (Gelatinase A)

A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.

Also Known As:

Gelatinase A; 72-kDa Gelatinase; 72-kDa Type IV Collagenase; MMP-2 Metalloproteinase; MMP2 Metalloproteinase; Matrix Metalloproteinase-2; 72 kDa Gelatinase; 72 kDa Type IV Collagenase; Gelatinase, 72-kDa; MMP 2 Metalloproteinase; Metalloproteinase 2, Matrix; Metalloproteinase, MMP-2; Metalloproteinase, MMP2

Networked: 3284 relevant articles (55 outcomes, 402 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Shun-Fa: 37 articles (10/2021 - 02/2002)
2.	Lovett, David H: 29 articles (01/2019 - 07/2002)
3.	Hsieh, Yih-Shou: 24 articles (10/2019 - 02/2002)
4.	Chung, Jing-Gung: 22 articles (05/2018 - 03/2006)
5.	Schulz, Richard: 20 articles (02/2022 - 08/2002)
6.	Sawicki, Grzegorz: 17 articles (06/2021 - 09/2002)
7.	Yang, Jai-Sing: 14 articles (01/2014 - 11/2009)
8.	Chu, Shu-Chen: 13 articles (09/2012 - 01/2003)
9.	Chen, Pei-Ni: 11 articles (10/2021 - 02/2004)
10.	Sawicka, Jolanta: 11 articles (06/2021 - 05/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Moreover, PFEE-C and PFEE-W significantly increased ROS generation in H22 cells and suppressed H22 cell migration through reducing the levels of matrix metalloproteinase -2 and -9. Further, PFEE-C inhibited H22 tumor growth in mouse model and improved the survival of tumor mice. " 01/01/2021 - "In present study, nanoparticles with the characteristics of photothermal/matrix metalloproteinase-2 (MMP-2) dual-responsive, tumor targeting, and size-variability were designed for enhancing the antitumor efficacy and achieving "on-demand" drug release markedly. " 01/01/2019 - "5 compounds of the total 17 showed significant cytotoxicity toward the studied cancer cultures and were submitted to further detailed analysis, including studies examining their influence on gelatinase A and B expression, as well as on the cancer cells migration and adhesion to an extracellular matrix. " 04/01/2018 - "The results of the present study demonstrated that Rap2c overexpression promoted the migratory and invasive ability of cancer cells, and increased the activity of matrix metalloproteinase-2 (MMP2). " 11/01/2016 - "Subsequently, the present study investigated the association between the expression of nuclear EIF5A2 and matrix metalloproteinase-2 (MMP-2), which is an important factor for promoting cancer cell invasion. "
2.	Fibrosis (Cirrhosis) 07/01/2013 - "These changes were associated with altered myocardial substrate utilization and improved mitochondrial capacity and efficiency, as well as reduced oxidative stress, fibrosis, and intracellular matrix metalloproteinase 2 content. " 01/01/2023 - "The target gene matrix metalloproteinase 2 (MMP2) was selected for further study, and it was found to be related to the fibrosis process and the genes regulating fibrosis. " 04/03/2023 - "The role of matrix metalloproteinase-2 in lung fibrosis is unclear. " 04/03/2023 - "Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis. " 01/01/2023 - "The 16 common target genes of SH against cardiac fibrosis and HF included MMP2 (matrix metalloproteinase 2), and p38. "
3.	Inflammation (Inflammations) 01/01/2022 - "Matrix metalloproteinase-2 (MMP2) is involved in extracellular matrix (ECM) degradation, inflammation and angiogenesis to regulate the development and recovery of IS. " 10/20/2021 - "Synovial fluid matrix metalloproteinase 2 (MMP2) was measured in all samples using the western blot method as a positive control of OA inflammation. " 01/01/2019 - "However, whether matrix metalloproteinase-2 is detrimental or protective in early stages of allergic airway inflammation remains unclear. " 01/01/2019 - "Several evidence has demonstrated the involvement of matrix metalloproteinase-2 in allergic airway inflammation. " 12/01/2014 - "Increased levels of the matrix metalloproteinases-2 and -9 (also referred to gelatinase-A and -B, respectively) can be detected in intestinal inflammation. "
4.	Brain Ischemia (Cerebral Ischemia) 01/01/2017 - "Our recent studies showed that 2-h cerebral ischemia induced BBB damage in non-infarcted area and secreted matrix metalloproteinase-2 (MMP-2) accounted for this disruption. " 04/12/2002 - "In a study of cerebral ischemia, gelatinase A (MMP-2) was seen in astrocytic end-feet and stromelysin-1 (MMP-3) in microglia. " 12/03/2013 - "Matrix metalloproteinase-2 deletions protect against hemorrhagic transformation after 1 h of cerebral ischemia and 23 h of reperfusion." 06/14/2012 - "Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion." 12/01/2003 - "During focal cerebral ischemia, matrix metalloproteinase-2 (MMP-2) can contribute to the loss of microvessel integrity within ischemic regions by degrading the basal lamina. "
5.	Hyperplasia 05/01/2010 - "Serum levels of matrix metalloproteinase-2 as a marker of intimal hyperplasia." 09/16/2003 - "Deficiency of gelatinase a suppresses smooth muscle cell invasion and development of experimental intimal hyperplasia." 09/01/2003 - "Assessment of indirect hemagglutination and zymography procedures in evaluation of gelatinase a in patients with benign and malignant prostate hyperplasia." 07/01/2005 - "In this study, we analysed the circulating form of gelatinase A (MMP-2) in patients suffering from either benign prostate hyperplasia (n=54) or prostate cancer (n=26) versus normal individuals as control (n=26). " 09/01/2003 - "In this study, we have analyzed the circulating form of gelatinase A (MMP-2) in patients suffering from either benign prostate hyperplasia (n= 54) or prostate cancer (n= 26) and normal individuals as control (n= 26). "

Related Drugs and Biologics

1.	Collagen
2.	Matrix Metalloproteinase 9 (Gelatinase B)
3.	Proteins (Proteins, Gene)
4.	Messenger RNA (mRNA)
5.	Peptides (Polypeptides)
6.	Matrix Metalloproteinases (MMPs)
7.	Tissue Inhibitor of Metalloproteinase-2
8.	Tissue Inhibitor of Metalloproteinase-1
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Enzymes

Related Therapies and Procedures

1.	Debridement
2.	Aftercare (After-Treatment)
3.	Chemoradiotherapy
4.	Ligation
5.	Therapeutics