Pick Disease of the Brain (Pick's Disease)

A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Also Known As:

Networked: 388 relevant articles (6 outcomes, 32 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease)
2.	Frontotemporal Dementia (Semantic Dementia)
3.	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
4.	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
5.	Corticobasal Degeneration

Experts

1.	Dickson, Dennis W: 10 articles (01/2021 - 11/2003)
2.	Trojanowski, John Q: 9 articles (01/2021 - 06/2002)
3.	Ferrer, Isidre: 9 articles (02/2016 - 03/2004)
4.	Ferrer, I: 9 articles (02/2013 - 01/2001)
5.	Hasegawa, Masato: 8 articles (01/2022 - 04/2004)
6.	Goedert, Michel: 8 articles (01/2020 - 11/2003)
7.	Puig, B: 7 articles (04/2006 - 01/2001)
8.	Yoshida, Mari: 6 articles (01/2022 - 10/2006)
9.	Miller, Bruce L: 6 articles (01/2018 - 06/2002)
10.	Warren, Jason D: 5 articles (01/2021 - 09/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pick Disease of the Brain:

1.	Proteins (Proteins, Gene)FDA Link 06/01/2013 - "C1q, the classical complement pathway protein binds Hirano bodies in Pick's disease." 10/01/2006 - "The present results demonstrate that glial acidic protein is a target of oxidative damage in the frontal cortex in Pick's disease." 10/01/2006 - "In Pick's disease, increased AGE, CML, CEL, HNE and MDAL bands of about 50 kDa were observed in the frontal cortex (but not in the occipital cortex) in association with increased density of glial acidic protein bands. " 01/05/2005 - "As the gene for this protein is encoded on chromosome 21 and maybe overexpressed due to the gene dosage hypothesis based upon the presence of a third chromosome in trisomy 21, we decided to study expression in Down syndrome (DS) brain and used brains of patients with Alzheimer's (AD) and Pick's disease (PD) as controls. " 01/01/2022 - "Here, we confirm TNAP protein upregulation in the brains of Alzheimer's patients and found a similar TNAP increase in Pick's disease patients and P301S mice, a well-characterized mouse model of tauopathies. "
2.	Amyloid (Amyloid Fibrils)IBA 01/01/2018 - "One mixed PPA patient with a negative amyloid PET scan had Pick disease at autopsy. " 01/01/2005 - "M146L mutant PS-1 may predispose to both Pick's disease and AD by affecting multiple intracellular pathways involving tau phosphorylation and amyloid metabolism." 09/01/1999 - "We present a patient with early-onset Pick's disease in which selective nigral degeneration, KP1 expression of ghost Pick bodies and amyloid P-positive astrocytes were found. " 09/01/1999 - "KP1 expression of ghost Pick bodies, amyloid P-positive astrocytes and selective nigral degeneration in early onset Picks disease." 06/01/1996 - "These two subjects, both homozygous for the APOE-epsilon4 allele, were primarily diagnosed as having Creutzfeldt-Jakob disease and Pick's disease in the absence of significant neocortical amyloid deposition. "
3.	alpha-Crystallin B ChainIBA 10/01/1995 - "The remaining brains have frontal lobe degeneration: the use of alpha B-crystallin immunostaining, on these, to detect ballooned neurons may help to define two groups of patients, one of which we believe may represent a variant of Pick's disease. " 08/01/1992 - "alpha B Crystallin was expressed by the majority of ballooned neurons of Pick's disease and CJD, but not by those of the other disorders. " 06/01/1995 - "We studied the distribution of alpha B-crystallin-positive degenerating neurons in cases with progressive supranuclear palsy, and compared them with those in Pick's disease. " 08/01/1992 - "Ubiquitin and srp 27 expression was also restricted to abnormal neurons of Pick's disease and CJD, but the proportion of stained cells was less than that expressing alpha B-crystallin. " 01/01/2008 - "Pick disease (PiD) is a frontotemporal dementia characterized by frontal and temporal atrophy, neuronal loss, gliosis, ballooned neurons that are positive for alpha-B crystallin and neurofilament, and the presence of tau- and ubiquitin-positive Pick bodies. "
4.	Glucose (Dextrose)FDA LinkGeneric 01/01/1993 - "Patients with Pick's disease revealed decreased glucose metabolism in frontal and temporal regions. " 12/01/1986 - "[Disorders of glucose metabolism in Pick's disease]." 12/01/1986 - "Pick's disease can be differentiated against presenile dementia represented by Alzheimer's disease in that the pattern of reduced metabolism characteristic of Alzheimer's disease is different from that of Pick's disease where in accordance with the clinical syndrome the glucose metabolism in the frontal and temporobasal regions in reduced, involving also the structures of the hippocampus and an equally significant reduction of glucose metabolism in the caudate nucleus. "
5.	CyclodextrinsIBA 10/01/2019 - "Cyclodextrins are helpful in animal models and human subjects/patients afflicted with Neimann-Pick disease, including improving the neurologic component of the disease. " 05/01/2013 - "[Treatment with cyclodextrin for Niemann Pick s disease]."
6.	CalciumIBA 03/01/2007 - "In addition, patients with Pick's disease, which is part of the spectrum of frontotemporal lobar degeneration, showed improvement on calcium EDTA. " 01/01/2001 - "Calcium/calmodulin-dependent kinase II (alpha- and beta-CaM kinase II), and phosphorylated mitogen-activated extracellular signal-regulated protein kinase (MAPK/ERK-P), phosphorylated protein kinase of 38 kDa (p38-P) and phosphorylated stress-activated protein kinase (SAPK/JNK-P) expression have been examined in Alzheimer disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). "
7.	NeuropeptidesIBA 11/26/2015 - "We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with neurotrophic effects, ameliorates the pathology in amyloid precursor protein transgenic (tg) mouse model of AD and 4R tau, however it is unclear if CBL ameliorates the deficits and neuropathology in the mouse model of Pick's disease over expressing 3R tau. "
8.	Edetic Acid (EDTA)FDA Link 03/01/2007 - "In addition, patients with Pick's disease, which is part of the spectrum of frontotemporal lobar degeneration, showed improvement on calcium EDTA. "
9.	Rivastigmine (Exelon)FDA LinkGeneric 06/01/2009 - "We report a case of frontotemporal dementia, Pick's disease, which improved with rivastigmine treatment. " 06/01/2009 - "[Rivastigmine in a case of autopsy proved frontotemporal dementia (Pick's disease)]."
10.	tau Proteins (tau Protein)IBA 01/01/2018 - "Structures of filaments from Pick's disease reveal a novel tau protein fold." 09/01/2011 - "We use thiazine red fluorescence to specifically label and detect the filamentous tau protein pathology associated with Pick's disease, as several labs have done previously. " 01/18/2011 - "Abnormal deposits of hyperphosphorylated and ubiquitinated tau protein are present in 30% of cases, which include the classic presentation of Pick disease with argyrophilic, intraneuronal inclusions known as Pick bodies. " 02/01/2008 - "Even though the inclusions are morphologically different, flame-shape structure for AD vs. spherical structure for Pick disease, both have filaments mainly composed of tau protein. " 12/01/2006 - "Surviving VENs were often dysmorphic, with pathological tau protein accumulation in Pick's disease. "

Therapies and Procedures

1.	Therapeutics 05/01/1995 - "Pick's disease: possible new directions in prophylaxis and therapy." 01/01/1940 - "Hepatosplenomegaly Resembling Niemann-Pick's Disease: Recovery Following Liver Therapy." 09/01/2003 - "At the Frontotemporal Dementia and Pick's Disease Conference, recent data concerning the epidemiology, diagnosis, and therapy of frontotemporal dementia were presented. " 06/01/2001 - "In this article the authors review the phenotype of these Tg mice and discuss how the availability of relevant animal model of tauopathies will facilitate discovery of more effective therapies to treat Pick's disease and related disorders characterized by filamentous tau pathology in selectively vulnerable regions of the CNS." 01/01/2020 - "No effective therapeutics to treat neurodegenerative diseases exist, despite significant attempts to find drugs that can reduce or rescue the debilitating symptoms of tauopathies such as Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis, or Pick's disease. "
2.	Lasers (Laser) 12/01/2005 - "As a model, pick bodies were chosen and laser-microdissected from three different brain regions of two patients with Pick's disease. " 02/01/2008 - "In this study, we used laser scanning confocal microscopy to characterize and compare the processing of tau protein during Pick disease with that found in AD. " 03/01/2006 - "By utilizing a novel combinatorial method of a Laser Microdissection System and Western blot analysis, we demonstrate that a distinct isoform of abnormally phosphorylated tau (69 kDa, Tau 69) predominantly aggregated in laser-microdissected Pick bodies (PBs) in sporadic Pick's disease. "
3.	Nursing Care 04/20/1983 - "Nursing care study: a patient with Pick's disease."
4.	Pericardiectomy 01/01/1936 - "Pericardiectomy in a Case of Pick's Disease."
5.	Ligation 01/01/2022 - "Immunofluorescent and proximity-ligation assays revealed altered SFPQ/FUS-interactions in the neuronal nuclei of progressive supranuclear palsy, corticobasal degeneration and amyotrophic lateral sclerosis-TDP cases but not in Alzheimer's disease, Pick's disease and globular glial tauopathy cases. "