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Pick Disease of the Brain (Pick's Disease)

A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)
Also Known As:
Pick's Disease; Brain Atrophy, Circumscribed Lobar; Pick Disease; Picks Disease of Brain; Atrophies, Lobar (Brain); Atrophy, Lobar (Brain); Disease, Pick; Disease, Pick's; Lobar Atrophies (Brain); Picks Disease; Circumscribed Lobar Atrophy of the Brain; Lobar Atrophy (Brain); Lobar Atrophy of the Brain
Networked: 286 relevant articles (5 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Frontotemporal Lobar Degeneration (Semantic Dementia)
3. Frontotemporal Dementia
4. Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
5. Dementia (Dementias)

Experts

1. Ferrer, I: 9 articles (02/2013 - 01/2001)
2. Trojanowski, John Q: 8 articles (01/2016 - 06/2002)
3. Lee, Virginia M-Y: 7 articles (01/2016 - 06/2002)
4. Ferrer, Isidre: 7 articles (12/2014 - 03/2004)
5. Puig, B: 7 articles (04/2006 - 01/2001)
6. Miller, Bruce L: 6 articles (12/2013 - 06/2002)
7. Grossman, Murray: 5 articles (01/2016 - 06/2002)
8. Tsuchiya, Kuniaki: 5 articles (05/2009 - 05/2003)
9. Revesz, T: 5 articles (06/2005 - 02/2000)
10. Arnold, Steven E: 4 articles (01/2016 - 02/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pick Disease of the Brain:
1. Amyloid (Amyloid Fibrils)IBA
2. alpha-Crystallin B ChainIBA
3. CalciumIBA
4. Glucose (Dextrose)FDA LinkGeneric
5. NeuropeptidesIBA
6. Edetic Acid (EDTA)FDA Link
7. rivastigmine (Exelon)FDA LinkGeneric
8. tau Proteins (tau Protein)IBA
9. Protein Isoforms (Isoforms)IBA
10. Apolipoproteins E (ApoE)IBA

Therapies and Procedures

1. Lasers (Laser)
2. Nursing Care
3. Pericardiectomy
4. Home Nursing (Nursing, Home)
5. Drug Therapy (Chemotherapy)