|1.||Zamponi, Gerald W: 3 articles (07/2014 - 01/2012)|
|2.||Higaki, Jitsuo: 3 articles (12/2013 - 06/2006)|
|3.||Silverman, Richard B: 3 articles (07/2013 - 01/2012)|
|4.||Luan, Chi-Hao: 3 articles (07/2013 - 01/2012)|
|5.||Kang, Soosung: 3 articles (07/2013 - 01/2012)|
|6.||Cooper, Garry: 3 articles (07/2013 - 01/2012)|
|7.||Porreca, Frank: 3 articles (06/2012 - 09/2003)|
|8.||Kim-Mitsuyama, Shokei: 3 articles (12/2011 - 01/2005)|
|9.||Tao, Jin: 3 articles (09/2007 - 10/2005)|
|10.||Hess, Ellen J: 3 articles (01/2006 - 01/2003)|
|1.||Hypertension (High Blood Pressure)
09/01/1994 - "These studies test the hypothesis that increased L-type calcium channel activity in vasculature is a hallmark or general characteristic of hypertension. "
09/05/2014 - "This has been explained by the depolarized resting potential of VSM in comparison with heart muscle cells and during hypertension, because both favor the "high affinity" inactivated state of the L-type calcium channel (LCC). "
07/01/2014 - "1,4-Dihydropyridines (DHPs) are an important class of L-type calcium channel blockers that are used to treat conditions such as hypertension and angina. "
05/01/2009 - "In different rodent models of hypertension, vascular voltage-gated L-type calcium channel (Ca(L)) current and vascular tone is increased because of increased expression of the noncardiac form of the Ca(L) (Ca(v)1.2). "
01/01/2009 - "Impaired control of L-type voltage-dependent calcium channels in experimental hypertension."
|2.||Alzheimer Disease (Alzheimer's Disease)
04/01/2012 - "Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease."
11/01/1999 - "L-type calcium channels in the hippocampus and cerebellum of Alzheimer's disease brain tissue."
03/01/2011 - "Several large population-based or clinical trial studies have suggested that certain dihydropyridine (DHP) L-type calcium channel blockers (CCBs) used for the treatment of hypertension may confer protection against the development of Alzheimer disease (AD). "
08/01/1995 - "Preliminary evidence suggests that nimodipine, an L-type calcium channel blocker, is effective in treating some patients with rapidly cycling affective disorders and some phases of Alzheimer's disease, i.e., two syndromes associated with transient or permanent reductions in cerebrospinal fluid (CSF) somatostatin, respectively. "
01/01/1995 - "Role of L-type calcium channel modulation in nonconvulsive epilepsy in rats."
01/01/2000 - "The aim of the present investigation was to compare the antiepileptic efficacy of the specific L-type calcium channel blocker nifedipine in hippocampal and neocortical slice preparations in the Mg2+-free model of epilepsy. "
09/18/2015 - "L-type Calcium Channel Blockers Enhance Trafficking and Function of Epilepsy-associated α1(D219N) Subunits of GABA(A) Receptors."
10/31/1997 - "It is concluded that L-type calcium channels are involved in strychnine-induced epilepsy, but to a greater extent in the neocortex than in the hippocampus."
09/16/1996 - "In human neocortical slices the specific L-type calcium channel blocker verapamil had been shown to be antiepileptic in the low Mg(2+)-model of epilepsy. "
|4.||Bipolar Disorder (Mania)
10/01/2012 - "One of the most consistent genetic findings to have emerged from bipolar disorder genome wide association studies (GWAS) is with CACNA1C, a gene that codes for the α(1C) subunit of the Ca(v)1.2 voltage-dependent L-type calcium channel (LTCC). "
01/05/2010 - "Variations in voltage-dependent calcium channel L-type, alpha 1C subunit (CACNA1C) gene have been associated with bipolar disorder in a recent meta-analysis of genome-wide association studies [Ferreira et al., 2008]. "
03/01/2014 - "Motivated by genetic association data implicating L-type calcium channels in bipolar disorder liability, we sought to estimate the tolerability, safety, and efficacy of isradipine in the adjunctive treatment of bipolar depression. "
09/29/1999 - "Moreover, the L-type calcium channel blocker verapamil is reported to be effective in mania, but it may exacerbate schizophrenia. "
05/01/2008 - "Given the ready availability of L-type calcium channel blockers, our results have clinical ramifications for the treatment of seizures associated with HH lesions."
05/01/2008 - "GABAA receptor-mediated excitation, due in part to differential expression of NKCC1 and KCC2 and subsequent activation of L-type calcium channels, may contribute to seizure genesis in HH tissue. "
12/01/2015 - "Germline mutations in CACNA1D, which codes for an L-type calcium channel, have so far only been found in 2 cases with a syndrome of primary aldosteronism, seizures, and neurologic abnormalities. "
04/01/2006 - "In conclusion, our study provides further evidence on the antiepileptic effect of L-type calcium channel blocker nifedipine by showing its protective effect on seizure activity induced by PTX."
12/01/1999 - "We used this model to study the influence of nicardipine, an antagonist of L-type voltage-dependent calcium channels, on kindling seizure development as well as related learning impairments. "
|3.||N-Type Calcium Channels (N-Type Calcium Channel)
|5.||Calcium Channel Blockers (Blockers, Calcium Channel)
|7.||Calcium Channels (Calcium Channel)
|10.||Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
|1.||Artificial Respiration (Mechanical Ventilation)
|2.||Positive-Pressure Respiration (PEEP)
|5.||Vagus Nerve Stimulation