A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Also Known As:
Ob Gene Product; Obese Gene Product; Gene Product, Ob; Gene Product, Obese; Ob Protein; Obese Protein
Networked: 12695 relevant articles (438 outcomes, 2314 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Mantzoros, Christos S: 78 articles (01/2016 - 03/2002)
2. Myers, Martin G: 39 articles (06/2015 - 05/2003)
3. Matarese, Giuseppe: 37 articles (09/2015 - 04/2002)
4. Gorden, Phillip: 29 articles (01/2016 - 02/2002)
5. Kalra, Satya P: 29 articles (12/2015 - 05/2002)
6. Rahmouni, Kamal: 28 articles (09/2015 - 02/2002)
7. Xue, Hui: 28 articles (08/2014 - 01/2002)
8. Gertler, Arieh: 27 articles (06/2015 - 06/2005)
9. Schwartz, Michael W: 27 articles (01/2015 - 03/2002)
10. Elmquist, Joel K: 25 articles (07/2015 - 04/2002)

Related Diseases

1. Body Weight (Weight, Body)
01/01/2014 - "However, treating obese people with exogenous leptin was unsuccessful in most cases since most of them present already high circulating leptin levels to which they do not respond anymore defining the so-called state of "leptin resistance." Indeed, leptin therapy is unsuccessful to lower body weight in commonly obese people but effective in people with rare single gene mutations of the leptin gene. "
01/01/2014 - "These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin. "
01/01/2013 - "Genetically obese females reared by lean dams showed normalized early levels of leptin and reduced body weight, food intake and body fat at adulthood; normalized estrous cycle structure and food intake across the cycle, improved hormonal profile and peripheral leptin sensitivity and a remarkable progress in self-control when exposed to a high fat/palatable diet. "
06/01/2005 - "Recent studies indicate that the passive range of motion exercise of the extremities results in a significantly greater increase of body weight, increased bone mineralization, increased bone formation markers and leptin levels, and attenuation of the natural post-natal decline in bone SOS. "
05/01/2002 - "In the present study, we tested the hypothesis that a single daily injection of the gut peptide CCK, together with continuous leptin infusion, would produce significantly greater loss of body weight than leptin alone. "
2. Obesity
3. Insulin Resistance
4. Weight Loss (Weight Reduction)
5. Weight Gain

Related Drugs and Biologics

1. Insulin (Novolin)
2. Glucose (Dextrose)
3. Adiponectin
4. Resistin
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. Triglycerides (Triacylglycerol)
7. Blood Glucose (Blood Sugar)
8. Hormones
9. Leptin Receptors
10. Adipokines

Related Therapies and Procedures

1. Caloric Restriction
2. Bariatric Surgery
3. Injections
4. Gastric Bypass (Roux-en-Y Gastric Bypass)
5. Gastrectomy