Parkinsonian Disorders (Parkinsonism)

4717  relevant articles (251 outcomes, 452 trials/studies) found for this Disease

Parkinsonism; Ramsay Hunt Paralysis Syndrome; Autosomal Dominant Juvenile Parkinson Disease; Autosomal Dominant Juvenile Parkinsonism; Autosomal Dominant Parkinsonism; Autosomal Recessive Juvenile Parkinson Disease; Autosomal Recessive Parkinsonism; Autosomal Recesssive Juvenile Parkinsonism; Chromosome 6-Linked Autosomal Recessive Parkinsonism; Experimental Parkinson Disease; Experimental Parkinsonism; Experimental Parkinsonism, MPTP-Induced; Familial Parkinson Disease, Autosomal Recessive; Juvenile Parkinson Disease; Juvenile Parkinson Disease, Autosomal Dominant; Juvenile Parkinson Disease, Autosomal Recessive; Juvenile Parkinsonism, Autosomal Dominant; Juvenile Parkinsonism, Autosomal Recessive; MPTP-Induced Experimental Parkinsonism; Parkinson Disease, Autosomal Dominant. Juvenile; Parkinson Disease, Experimental; Parkinson Disease, Familial, Autosomal Recessive; Parkinson Disease, Juvenile; Parkinson Disease, Juvenile, Autosomal Dominant; Parkinsonian Diseases; Parkinsonian Syndromes; Parkinsonism, Juvenile, Autosomal Dominant; Parkinsonism, Juvenile, Autosomal Recessive; Chromosome 6 Linked Autosomal Recessive Parkinsonism; Diseases, Experimental Parkinson; Dominant Parkinsonism, Autosomal; Experimental Parkinson Diseases; Experimental Parkinsonism, MPTP Induced; Experimental Parkinsonisms; Juvenile Parkinsonism; Juvenile Parkinsonism, Familial; Juvenile Parkinsonisms; MPTP Induced Experimental Parkinsonism; Parkinson Diseases, Experimental; Parkinsonism, Autosomal Dominant; Parkinsonism, Autosomal Recessive; Parkinsonism, Familial Juvenile; Parkinsonism, MPTP-Induced Experimental; Parkinsonisms, Experimental; Parkinsonisms, Juvenile; Recessive Parkinsonism, Autosomal; Familial Juvenile Parkinsonism; Parkinsonian Syndrome; Parkinsonism, Experimental; Parkinsonism, Juvenile

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dyskinesias (Dyskinesia)
2.	Parkinson Disease (Parkinson's Disease)
3.	Tremor (Tremors)
4.	Dementia (Dementias)
5.	Psychomotor Agitation (Akathisia)

Experts

1.	Calabresi, Paolo: 7 articles (02/2008 - 08/2002)
2.	Picconi, Barbara: 6 articles (01/2008 - 08/2002)
3.	Barone, Paolo: 5 articles (07/2008 - 05/2002)
4.	Langston, J William: 5 articles (06/2008 - 05/2002)
5.	Perl, Daniel P: 5 articles (01/2008 - 05/2002)
6.	Bernardi, Giorgio: 5 articles (07/2004 - 08/2002)
7.	Centonze, Diego: 5 articles (07/2004 - 08/2002)
8.	Onofrj, Marco: 4 articles (06/2008 - 11/2003)
9.	Thomas, Astrid: 4 articles (06/2008 - 11/2003)
10.	Wszolek, Z K: 4 articles (01/2008 - 09/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Parkinsonian Disorders:

1.	Levodopa (L Dopa)FDA LinkGeneric 08/01/2006 - "Parkinsonism improved dramatically after levodopa therapy" 03/01/2003 - "All 3 patients responded dramatically to treatment with levodopa, and parkinsonism spontaneously improved or remitted over months" 01/01/2008 - "Camptocormia in parkinsonism is defined by marked anteroflexion of the trunk, which is relieved by lying down together with minimal or no response to levodopa" 01/01/2007 - "We describe a patient with juvenile levodopa-responsive Parkinsonism who reported a dramatic response to cigarette smoking with transient but marked improvement of motor symptoms associated with oculogyric crises and psychotic behavior" 12/01/1999 - "However, a marked improvement of all clinical symptoms with a low dose of L-dopa was reported in AR-DRD/parkinsonism patients" Order ALL the reference details at left...
2.	Dopamine (Intropin)FDA LinkGeneric 01/01/1996 - "Behavioral measures of parkinsonism that are more clinically relevant than rotometry have been developed for rats with severe unilateral dopamine depletions, and the validity of these measures is supported by reports that these parkinsonian symptoms are attenuated by drugs that are effective in the clinical setting" 07/01/1992 - "Furthermore, the data emphasize the importance of hypothalamic pathology in the development of Parkinsonism and suggest that intrahypothalamic administration of dopamine blocking agents might be useful in the treatment of Parkinsonism." 09/01/1998 - "Efficacy of grafted immortalized dopamine neurons in an animal model of parkinsonism: a review." 11/26/1992 - "Bilateral implantation of fetal mesencephalic tissue can induce substantial long-term functional improvement in patients with parkinsonism and severe dopamine depletion and is accompanied by increased uptake of fluorodopa by the striatum" 04/01/2008 - "Subsequent PET studies showed progressive loss of all pre-synaptic dopamine markers in the striatum with expression of parkinsonism" Order ALL the reference details at left...
3.	Carbidopa (Lodosyn)FDA LinkGeneric 02/01/1977 - "Effect of MK-486 alone on Parkinsonism; studies on the clinical symptoms and catecholamine concentrations in the blood, urine and cerebrospinal fluid]" 10/01/1978 - "Need for uncombined carbidopa to treat parkinsonism." 03/01/1980 - "The new carbidopa-levodopa ratio was 1:4. During 15 months, this treatment produced a moderate decrease in the severity of parkinsonism and a marked decrease in peripheral adverse reactions, without a significant increase in the central adverse effects of levodopa" 01/01/1997 - "Low-dose pergolide together with L-carbidopa is effective in the treatment of parkinsonism without side effects, even in advanced stages of the disease" 07/01/1990 - "1. We have used gait analysis to investigate the efficacy of maintenance therapy with a levodopa/carbidopa combination in patients with idiopathic Parkinsonism, who do not have overt fluctuations in control in relation to administration of medication" Order ALL the reference details at left...
4.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/01/1988 - "During the first few weeks following 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) administration, all monkeys gradually developed a parkinsonian syndrome, which partially, but not completely improved within 30-40 days in 2 animals" 09/01/1995 - "2. The efficacy of D-1 receptor agonists in the treatment of experimental parkinsonism in MPTP-treated primates is demonstrated" 07/01/2007 - "In the absence of human studies, we used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate models of Parkinsonism to verify correlation between the SPECT, immunohistochemical and behavioural data" 01/01/2006 - "Propagation of signals from the gastro-intestinal system towards the occipital cortex within sleep-wake cycle was investigated in three monkeys used in the study of sleep impairment in a chronic MPTP model of parkinsonism" 09/01/2004 - "The present studies were conducted to further define the nature of the cognitive impairment in a nonhuman primate model of early parkinsonism consequent to chronic low dose MPTP exposure and to further validate this model in monkeys trained to perform a battery of attentional and executive function tasks" Order ALL the reference details at left...
5.	Bromocriptine (Parlodel)FDA LinkGeneric 10/01/2005 - "TREATMENT AND OUTCOME: His parkinsonism responded well to treatment with bromocriptine, but he continued to stutter" 04/01/1987 - "Bromocriptine at doses of 20 mg/day or below may yield effective symptomatic improvement in de novo parkinsonism and may be considered as the initial treatment in young parkinsonian patients with only mild-to-moderate disability." 10/01/1978 - "However, the degree of improvement in the signs of parkinsonism was related to plasma bromocriptine levels was achieved" 03/01/1994 - "We conducted this study to determine whether bromocriptine, an agent widely used for treating parkinsonism, possesses antioxidant effects" 01/01/1978 - "Experimental and clinical studies on bromocriptine in the Parkinsonian syndrome." Order ALL the reference details at left...
6.	Amantadine (Aman)FDA LinkGeneric 08/15/1998 - "Amantadine is an antiviral agent that was unexpectedly found to cause symptomatic improvement in patients with Parkinsonism, although its mechanism of action remains to be elucidated" 02/02/1973 - "Efficacy of amantadine sulfate as a infusion solution in the treatment of parkinsonian syndrome]" 07/10/1970 - "This release may account for the reported efficacy of amantadine hydrochloride in the treatment of human parkinsonism." 09/01/2008 - "INTRODUCTION: Amantadine hydrochloride is an antiviral medication used as therapy for parkinsonism and as a cognitive enhancer" 11/01/2005 - "Once a parkinsonian syndrome was diagnosed, he was begun on amantadine and completely recovered within 1 week with no relapse of symptoms" Order ALL the reference details at left...
7.	Selegiline (E250)FDA LinkGeneric 01/01/1987 - "Therapeutic efficacy of R-(-)-deprenyl as adjuvant therapy in advanced parkinsonism." 01/01/1983 - "In a limited trial, deprenyl has produced promising results during this phase of parkinsonism" 01/01/1993 - "These results show that selegiline is safe and effective as monotherapy in early parkinsonism" 01/01/1993 - "The French Selegiline Multicenter Trial was carried out in 1990 to investigate whether the disability of de novo patients with parkinsonism could be improved during the first 3 months by monotherapy with selegiline (10 mg/day)" 03/14/2006 - "The authors present advantages and limitations of futility designs along with examples derived from the data archive of a large Phase III efficacy study of treatments to delay PD progression, the Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism (DATATOP) trial" Order ALL the reference details at left...
8.	Haloperidol (Haldol)FDA LinkGeneric 08/15/1995 - "These data suggest that the protective effects of GM1 ganglioside cotreatment on haloperidol-induced alterations in cholinergic systems can be relevant for protecting against the complications of neuroleptic-induced parkinsonism." 08/01/1995 - "Abnormal positron emission tomographic scanning results in a fourth patient, whose signs and symptoms had improved with psychotherapy and haloperidol therapy, emphasizes the possibility that prominent psychogenic features may be superimposed on organic parkinsonism in some patients" 05/01/1996 - "The aim of the present study was to find out whether haloperidol-induced rigidity was similar to that seen in parkinsonism" 11/01/1993 - "All patients completed the study, with the exception of one haloperidol-treated patient who developed severe parkinsonism" 03/28/2007 - "The D2 antagonist haloperidol produces parkinsonism in humans, and also induces motor effects in rats, such as suppression of locomotion" Order ALL the reference details at left...
9.	Clozapine (Clozaril)FDA LinkGeneric 08/01/2004 - "The HB was improved by very low-dose clozapine but the HB did not improve the parkinsonism" 03/11/1999 - "Multiple open-label studies have reported that treatment with clozapine at low doses ameliorates psychosis without worsening parkinsonism" 01/01/2001 - "OBJECTIVE: To report the results of the 12-week, prospective, open label extension of the 4-week, multicenter, placebo-controlled, double-blind PSYCLOPS (PSYchosis and CLOzapine in the treatment of Parkinsonism) trial" 05/01/2002 - "Only the atypical antipsychotic clozapine improves psychosis without worsening of parkinsonism" 02/01/2002 - "5) In practice, when adjusting antiparkinsonian treatment fails to strike a balance between psychotic and parkinsonism disorders, clozapine is the standard neuroleptic" Order ALL the reference details at left...
10.	Antipsychotic Agents (Antipsychotics)IBA 09/01/2000 - "Treatment of these symptoms is a dilemma in patients with parkinsonism because traditional antipsychotics that are usually effective in older people will often worsen motor symptoms and counteract the effect of antiparkinsonian medications" 10/01/2008 - "The present study was performed to investigate olfactory function in depressed patients with drug-induced parkinsonism under treatment with D2-blocking neuroleptic drugs compared to depressed controls on similar neuroleptic dose without EPS (no-EPS), and neuroleptic-naive depressed controls (no-NL)" 01/01/1999 - "In six patients who met the criteria of HIV-associated psychosis and who had previously developed moderate parkinsonism as a result of the use of typical neuroleptic agents, CZP was added in an open, rising dose study" 01/01/1996 - "Future studies of parkinsonism in AD should employ standardized clinical rating scales and should exclude patients on neuroleptics or analyze their results separately" 09/01/1988 - "The main result of this study was the demonstration of 1) an inverse relationship between parkinsonism and TD, and 2) an inconsistent response to withdrawal of various neuroleptics" Order ALL the reference details at left...

Therapies and Procedures

1.	Pallidotomy 01/01/2005 - "The effect of pallidotomy for alleviation of akinetic parkinsonism is modest but significant, and continues to be effective for at least 2 years" 12/01/1999 - "The akinesia of Parkinsonism is relieved by pallidotomy and subthalamic nucleotomy, but not by thalamotomy" 11/01/1999 - "CONCLUSION: Pallidotomy helped improve overall motor function in patients with parkinsonism and, for some patients, also improved postural stability." 05/01/2002 - "A second contralateral pallidotomy may reduce parkinsonism, although to a lesser degree compared with the first pallidotomy and with an increased risk for adverse effects." 01/01/2000 - "Although surgical options such as pallidotomy offer improvement of parkinsonism beyond the realm of pharmacologic treatment, judicious administration of drugs in combination can generally solve most problems of PD." Order ALL the reference details at left...
2.	Transplants (Transplant) 04/01/1993 - "Clinical neuromythology X. Faithful fashion: survival status of the brain transplant cure for parkinsonism." 05/01/1990 - "Clinical neuromythology VII. Artificial intelligence: the brain transplant cure for parkinsonism." 01/01/1990 - "Although behavioral recovery occurred in only those monkeys that received appropriate transplants (fetal SN to host CN) and not in those that received inappropriate grafts (fetal cerebellum to CN or fetal SN to cortex), the CSF HVA levels did not distinguish those monkeys with improved parkinsonism from those that remained severely parkinsonian" 10/01/1997 - "Studies in nonhuman primates with experimental parkinsonism have shown that intrastriatal cografts of autologous adrenal medulla and peripheral nerve yield greater behavioral improvement and graft survival than do adrenal medulla grafts alone" 02/01/1996 - "It is suggested that labeling and identification of living donor cells with FLM is feasible and thus can provide a powerful tool to study the mechanisms underlying graft-induced amelioration of neurological deficits in parkinsonism by enabling physiological assessments of grafted cells." Order ALL the reference details at left...
3.	Deep Brain Stimulation 04/01/2008 - "OBJECTIVES: To study the frequency of different gene mutations in patients with early-onset parkinsonism and bilateral subthalamic nucleus deep brain stimulation (STN-DBS) and the short- and long-term surgical outcome in mutation-positive (MUT+) and -negative (MUT-) patients" 09/01/2008 - "The finding that anterior but not posterior PPTg affects motor activity has significance for developing therapeutic strategies for Parkinsonism using deep brain stimulation aimed here." 11/23/2007 - "Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonism." 11/15/2007 - "Deep brain stimulation for the treatment of atypical parkinsonism." 08/01/2007 - "Recent identification of novel deep brain stimulation targets such as the pedunculopontine nucleus may help treat the balance and gait disorder in atypical parkinsonian disorders in the near future" Order ALL the reference details at left...
4.	Transplantation (Transplant Recipients) 01/01/1991 - "Formation of a European network of the groups involved in clinical and preclinical studies related to intracerebral transplantation for Parkinsonism." 03/01/1990 - "Continued transplantation studies in animal models of parkinsonism are necessary for better elucidation of these factors." 06/01/2005 - "In subjects who did not meet Core Assessment Program for Intracerebral Transplantations diagnostic criteria for PD at baseline, the presence of cardinal signs of parkinsonism was not associated with lower baseline UPSIT scores nor with a subsequent decline" 11/01/2002 - "These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism." 08/01/1996 - "The transplantation of catecholaminergic tissues is a possible therapy for parkinsonism" Order ALL the reference details at left...
5.	Activities of Daily Living (ADL) 11/01/1993 - "This report demonstrates the efficacy of extremely weak MF in reversing some of the cognitive abnormalities in Parkinsonism, notably neglect and visuoperceptive deficits, which contribute significantly to impairment of the patient's daily living activities." 06/01/1992 - "Eleven patients were recruited in this open trial and were objectively assessed by Unified Rating Scale for Parkinsonism of Columbia University, Modified Hoehn and Yahr Staging and Schwab and England activities of daily living" 10/01/2007 - "Depression was associated with a younger age and age at onset and female gender, but not with severity of parkinsonism, cognition or activities of daily living or laterality of motor symptoms" 03/01/1999 - "Multiple falls were associated with DLB, parkinsonism, previous falls, greater impairment of activities of daily living and older age" 02/01/1993 - "Reversible gait abnormalities with characteristics of a 'lower-half parkinsonism' were associated with a disorder of axial movement, disability (as assessed by an activities of daily living score), and low mental test score" Order ALL the reference details at left...