ADP-Ribosylation Factors (ADP-Ribosylation Factor)

MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(ADP-RIBOSE) TRANSFERASE of the CHOLERA TOXIN catalytic subunit. They are involved in vesicle trafficking and activation of PHOSPHOLIPASE D. This enzyme was formerly listed as EC 3.6.1.47

Also Known As:

Networked: 121 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Thelma, B K: 3 articles (01/2022 - 07/2018)
2.	Guerrini, Renzo: 3 articles (11/2013 - 01/2004)
3.	Kanjilal, Maumita: 2 articles (01/2021 - 07/2018)
4.	Kumar, Uma: 2 articles (01/2021 - 07/2018)
5.	Pandey, Anuj Kumar: 2 articles (01/2021 - 07/2018)
6.	Chano, Tokuhiro: 2 articles (01/2019 - 01/2019)
7.	Isono, Takahiro: 2 articles (01/2019 - 01/2019)
8.	Cheetham, Michael E: 2 articles (01/2018 - 08/2013)
9.	Hardcastle, Alison J: 2 articles (01/2018 - 08/2013)
10.	Webster, Andrew R: 2 articles (01/2018 - 08/2013)

Related Diseases

1.	Infections 01/01/2021 - "Using human THP1-derived macrophages as a model, we found that infection of Mtb H37Ra transiently reduced the level of ASAP1, an ADP ribosylation factor (Arf)-GTPase activating protein. " 01/01/2010 - "However, the ADP ribosylation factors (Arfs), also belonging to the regulatory GTP-binding proteins and playing a central role in membrane trafficking, have not been reported yet in shrimp and their relationship with WSSV infection is completely unknown to date. " 11/01/2017 - "The three differentially expressed genes, Single von Willebrand factor type C domain protein (pmSVC), P53 protein gene (pmP53) and ADP ribosylation factor (pmArf) were up-regulated against WSSV infection and were further characterized by gene silencing to study the role of these shrimp immune genes on WSSV multiplication. " 06/28/2011 - "During Pseudomonas syringae pathovar tomato (Pst) DC3000 infection of Arabidopsis, a host ADP ribosylation factor guanine nucleotide exchange factor, AtMIN7, is destabilized by the pathogen effector HopM1 through the host 26S proteasome. " 01/01/2018 - "The phagocytosis of hyalinocytes seemed to be enhanced during the infection, because several proteins that involved in phagocytosis, including clathrin heavy chain, ADP ribosylation factor 4 and Alpha2 macroglobulin were up-regulated in hyalinocytes upon WSSV infection. "
2.	Breast Neoplasms (Breast Cancer) 11/15/2019 - "Up-regulated ADP-Ribosylation factor 3 promotes breast cancer cell proliferation through the participation of FOXO1." 03/29/2016 - "ADP-ribosylation factor (ARF) 1 has emerged as a key regulator of invasion in breast cancer cells. " 10/15/2009 - "ADP ribosylation factor like 2 (Arl2) regulates breast tumor aggressivity in immunodeficient mice." 01/01/2020 - "In this study, we investigated the role of activating transcription factor 3 (ATF3) and ADP-ribosylation factor like-4 (ARL4) in human breast cancer, and the associated mechanisms. " 10/01/2020 - "The biological function of ADP ribosylation factor like GTPase 5B (ARL5B) in breast cancer cells was evaluated by wound healing assay and Transwell invasion assay. "
3.	Carcinogenesis 10/30/2023 - "The expression of ADP-ribosylation factor (Arf)-like 4c (Arl4c) has been shown to induce cell proliferation, and is thereby involved in epithelial morphogenesis and tumorigenesis. " 01/01/2019 - "Recently, a growing number of ADP ribosylation factor (ARF) family members has been suggested to be critical in tumorigenesis. " 01/01/2016 - "The aim of this study was to investigate the expression of ADP-ribosylation factor (ARF)-like 4c (Arl4c) in colorectal cancer (CRC) in Chinese populations and an AOM/DSS-induced mouse colorectal carcinogenesis model, and its prognostic value in patients with CRC. " 01/01/2016 - "ADP-ribosylation factor (ARF)-like 4c (Arl4c) has been reported to promote tumorigenesis in colorectal and lung cancers and may represent a novel therapeutic target. " 06/01/2023 - "ADP-ribosylation factor (ARF)-like 4c (ARL4C), the expression of which is reportedly induced by p63 and/or the MEK/ERK-MAPK pathway in OSCC cells, has been shown to promote tumorigenesis. "
4.	Rheumatoid Arthritis 01/01/2021 - "ADP ribosylation factor like protein 15 (ARL15) was identified as a novel susceptibility gene for rheumatoid arthritis (RA) based on a genomewide association study in a north Indian cohort. " 01/01/2022 - "Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis." 07/01/2018 - "Functional characterisation of ADP ribosylation factor-like protein 15 in rheumatoid arthritis synovial fibroblasts." 11/07/2023 - "The ADP ribosylation factor like protein 15 (ARL15) gene encodes for an uncharacterized GTPase associated with rheumatoid arthritis (RA) and other metabolic disorders. " 12/01/2017 - "Objective To establish the methods for detecting single nucleotide polymorphisms (SNPs) of ADP-ribosylation factor-like GTPase 15 (ARL15), major histocompatibility complex class II-DM alpha (HLA-DMA ) and nuclear factor kappa B subunit 2 (NFKB2) genes using high resolution melting (HRM) technology, and to explore the association of those SNPs with the susceptibility of rheumatoid arthritis (RA) in northwestern Han Chinese population. "
5.	Colorectal Neoplasms (Colorectal Cancer) 03/01/2014 - "microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma." 01/01/2016 - "The aim of this study was to investigate the expression of ADP-ribosylation factor (ARF)-like 4c (Arl4c) in colorectal cancer (CRC) in Chinese populations and an AOM/DSS-induced mouse colorectal carcinogenesis model, and its prognostic value in patients with CRC. " 02/15/1998 - "We have used cDNAs coding for novel ADP-ribosylation factor-like molecules (ARL184 and ARL184Delta) to alter 19-9 antigen glycoprotein secretion in cultured human colorectal carcinoma cells SW1116 by transfection and cloning. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	GTP-Binding Proteins (G-Protein)
3.	Enzymes
4.	Activating Transcription Factor 3
5.	Virulence Factors (Pathogenicity Factors)
6.	Membrane Transport Proteins (Biological Pump)
7.	Calcineurin
8.	von Willebrand Factor
9.	Serine (L-Serine)
10.	Peptide Hydrolases (Proteases)

Related Therapies and Procedures

1.	Therapeutics