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ral Guanine Nucleotide Exchange Factor

A guanine nucleotide exchange factor that stimulates the dissociation of GDP from RAL GTP-BINDING PROTEINS. It also has GDP exchange activity towards other MONOMERIC GTP-BINDING PROTEINS.
Also Known As:
ral-GDS; ral GDS; ral GDP Dissociation Stimulator; ralGDS
Networked: 31 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Esteller, Manel: 2 articles (06/2015 - 08/2013)
2. Pinyol, Roser: 1 article (06/2015)
3. Méndez-González, Jesús: 1 article (06/2015)
4. HEPTROMIC Consortium: 1 article (06/2015)
5. Cornella, Helena: 1 article (06/2015)
6. Portela, Anna: 1 article (06/2015)
7. Llovet, Josep M: 1 article (06/2015)
8. Imbeaud, Sandrine: 1 article (06/2015)
9. Fuster, Josep: 1 article (06/2015)
10. Zucman-Rossi, Jessica: 1 article (06/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Cardiomegaly (Heart Hypertrophy)
3. Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
4. Squamous Cell Carcinoma (Epidermoid Carcinoma)
5. Breast Neoplasms (Breast Cancer)
01/01/2015 - "Our data suggest that RILP suppresses the invasion of breast cancer cells by interacting with RalGDS to inhibit its GEF activity for RalA. "
01/01/2015 - "RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS."
07/01/2014 - "BMI showed a positive association with the methylation of extracellular superoxide dismutase (r = 0.21, p < 0.05), Ras-association (RalGDS/AF-6) domain family member 1 (RASSF1A) (r = 0.31, p < 0.001), and breast cancer type 1 susceptibility protein (r = 0.19, p < 0.05); and inverse association with methylation of BNIP3 (r = -0.48, p < 0.0001). "
12/01/2004 - "In comparison with the normal mucosa of the non-cancer patients, the following 14 genes displayed no tumor associated changes: breast cancer 1, early onset (BRCA1), cadherin 1, type 1, E-cadherin (epithelial) (CDH1), death-associated protein kinase 1 (DAPK1), DNA (cytosine-5-)-methyltransferase 1 (DNMT1), melanoma antigen, family A, 1 (directs expression of antigen MZ2-E) (MAGEA1), tumor suppressor candidate 3 (N33), cyclin-dependent kinase inhibitor 1A (p21, Cip1) (p21(WAF1)), cyclin-dependent kinase inhibitor 1B (p27, Kip1) (p27(KIP1)), phosphatase and tensin homolog (mutated in multiple advanced cancers 1) (PTEN), retinoic acid receptor, beta (RAR- , Ras association (RalGDS/AF-6) domain family 1 C (RASSF1C), secreted frizzled-related protein 1 (SFRP1), tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) (TIMP3), and von Hippel-Lindau syndrome (VHL). "

Related Drugs and Biologics

1. Cyclin-Dependent Kinase Inhibitor p16
2. retinoic acid receptor beta
3. FRZB protein
4. Estrogen Receptor alpha
5. Ephrin-B2 (Ephrin B2)
6. Monomeric GTP-Binding Proteins
7. Progesterone Receptors (Progesterone Receptor)
8. Insulin (Novolin)
9. GTP Phosphohydrolases (GTPases)
10. Cadherins (E-Cadherin)