Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)

A guanine nucleotide exchange factor that acts to restore EUKARYOTIC INITIATION FACTOR-2 to its GTP bound form.

Also Known As:

Eukaryotic Initiation Factor 2B; EIF2B; EIF2B-alpha; EIF2B-beta; EIF2B-delta; EIF2B-epsilon; EIF2B-gamma; Eukaryotic Initiation Factor-2B, alpha Subunit; Eukaryotic Initiation Factor-2B, beta Subunit; Eukaryotic Initiation Factor-2B, delta Subunit; Eukaryotic Initiation Factor-2B, epsilon Subunit; Eukaryotic Initiation Factor-2B, gamma Subunit; Eukaryotic Peptide Initiation Factor-2B; EIF 2B; EIF2B alpha; EIF2B beta; EIF2B delta; EIF2B epsilon; EIF2B gamma; Eukaryotic Initiation Factor 2B, alpha Subunit; Eukaryotic Initiation Factor 2B, beta Subunit; Eukaryotic Initiation Factor 2B, delta Subunit; Eukaryotic Initiation Factor 2B, epsilon Subunit; Eukaryotic Initiation Factor 2B, gamma Subunit; Eukaryotic Peptide Initiation Factor 2B; Peptide Initiation Factor EIF 2B; EIF-2B; EIF2B1; Peptide Initiation Factor EIF-2B

Networked: 152 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Ribosomal Proteins: 1138
    - Peptide Initiation Factors: 1364
      - Eukaryotic Initiation Factors: 22
        Eukaryotic Initiation Factor-2B: 152
        human EIF2B3 protein
        human EIF2B5 protein
        Nicotiana tabacum NeIF2Bbeta protein
        S cerevisiae GCD2 protein
        S cerevisiae GCD6 protein
        S cerevisiae GCD7 protein
        S cerevisiae GCN3 protein
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        Eukaryotic Initiation Factor-2B: 152
        human EIF2B3 protein
        human EIF2B5 protein
        Nicotiana tabacum NeIF2Bbeta protein
        S cerevisiae GCD2 protein
        S cerevisiae GCD6 protein
        S cerevisiae GCD7 protein
        S cerevisiae GCN3 protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        Eukaryotic Initiation Factor-2B: 152
        human EIF2B3 protein
        human EIF2B5 protein
        Nicotiana tabacum NeIF2Bbeta protein
        S cerevisiae GCD2 protein
        S cerevisiae GCD6 protein
        S cerevisiae GCD7 protein
        S cerevisiae GCN3 protein

Experts

1.	Proud, Christopher G: 12 articles (01/2022 - 10/2002)
2.	Boespflug-Tanguy, Odile: 9 articles (01/2020 - 06/2003)
3.	van der Knaap, Marjo S: 9 articles (01/2018 - 02/2002)
4.	Elroy-Stein, Orna: 8 articles (01/2021 - 10/2005)
5.	Pavitt, Graham D: 8 articles (11/2018 - 03/2004)
6.	Fogli, Anne: 8 articles (01/2013 - 06/2003)
7.	Schiffmann, Raphael: 8 articles (12/2009 - 06/2003)
8.	Wu, Ye: 7 articles (01/2021 - 02/2009)
9.	Scheper, Gert C: 6 articles (01/2013 - 11/2003)
10.	Kimball, Scot R: 6 articles (10/2011 - 11/2002)

Related Diseases

1.	Ischemia 10/01/2002 - "Thus, several different processes contributed to ischemia-induced suppression of the initiation of protein synthesis: a long-lasting dephosphorylation of eIF2B epsilon and p70 S6K starting during ischemia, a transient phosphorylation of eIF2alpha during early reperfusion, and a marked decrease of eIF2B epsilon, eIF4G1, and p70 S6K protein levels starting during vascular occlusion (eIF4G1). " 10/01/2002 - "eIF2B epsilon and p70 S6 kinase were completely dephosphorylated during ischemia and phosphorylation did not recover completely following reperfusion. " 10/01/2002 - "In this study, we investigated ischemia-induced changes in protein levels and phosphorylation states of the initiation factors eIF2alpha, eIF2B epsilon, and eIF4G1 and of p70 S6 kinase, proteins playing a central role in the control of the initiation of translation. " 08/01/2006 - "Activation of Akt stimulated signaling through the protein kinase mammalian target of rapamycin, as evidenced by increased phosphorylation of two of its effectors, the ribosomal protein S6 kinase and the eukaryotic initiation factor eIF4E binding protein 1. Ischemia and reperfusion also resulted in increased phosphorylation of eIF2 and eIF2B. "
2.	Bipolar Disorder (Manic Depressive Psychosis) 02/01/2007 - "For unknown reasons, oligodendrocytes appear to be particularly prone to defects in the translation initiation complex (EIF2B) and the convergence of these environmental and genomic signalling pathways on this area might well explain their vulnerability in bipolar disorder." 11/01/2007 - "eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?" 07/12/2002 - "We used Western blot analysis to quantify the protein level of the catalytic epsilon (epsilon) subunit of eIF-2B in brains of rats fed lithium chloride (LiCl) for 6 weeks so as to produce a brain lithium concentration that is therapeutically effective in bipolar disorder. "
3.	Leukoencephalopathies 04/01/2014 - "The previous studies have shown that mutations in five subunits of eIF2B cause white matter disease of the brain and thus EIF2B is the main culprit in development of white matter disease. " 04/01/2010 - "[Advances in functional study of EIF2B mutations in leukoencephalopathy with vanishing white matter]." 01/01/2021 - "Thereby, it illuminates the central involvement of astrocytes in Vanishing White Matter Disease (VWMD), a genetic neurodegenerative leukodystrophy caused by homozygous hypomorphic mutations in genes encoding any of the 5 subunits of eIF2B." 01/01/2021 - "Mutations within eIF2B result in the fatal disease, leukoencephalopathy with vanishing white matter (VWM). " 06/01/2020 - "eIF2B gene mutations cause leukoencephalopathy called vanishing white matter disease (VWM) in humans and slow growth (Slg-) and general control derepression (Gcd-) phenotypes in Saccharomyces cerevisiae. "
4.	Sepsis (Septicemia) 01/01/1996 - "In the present study, we investigated the expression of two subunits of eIF-2B, i.e., the beta- and epsilon-subunits during sepsis. " 08/01/2010 - "In an effort to restore a deficit in eIF2B activity, we utilized an established model of chronic sepsis in which skeletal muscle eIF2B activity is known to be impaired. " 01/01/1996 - "The expression of both beta- and epsilon-subunits of eIF-2B in gastrocnemius was decreased approximately 50% from control values during the first 5 days after induction of sepsis. " 01/01/1996 - "Altered expression of eukaryotic initiation factor 2B in skeletal muscle during sepsis." 01/01/1996 - "Expression of eIF-2B epsilon was not altered in heart during sepsis or in gastrocnemius from nonseptic abscess animals. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 04/15/2015 - "By modulating eIF2B function, ISRIB promises to be an invaluable tool in proof-of-principle studies aiming to ameliorate cognitive defects resulting from neurodegenerative diseases. " 01/01/2020 - "Here, we discuss the recent reports on the structure, function, and regulation of eIF2B; the preclinical data on the use of ISR inhibitors for the treatment of neurodegenerative disorders; and how the new structural and biochemical information can inform and influence the use of eIF2B as a therapeutic target." 01/01/2017 - "Further dissection of the signaling network associated with eIF2B function will help generating therapeutic strategies for VWM disease and possibly other neurodegenerative disorders." 07/01/2012 - "Leukodystrophy with vanishing white matter (VWM) is a neurodegenerative disorder with autosomal recessive traits that is caused by alteration of the eukaryotic translation initiation factor-2B (EIF2B). " 01/01/2022 - "Deregulated ISR has been linked to neurodegenerative disorders and cancer, positioning EIF2B as a promising therapeutic target. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Lithium Chloride
3.	Lithium
4.	Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)
5.	Peptide Initiation Factors (Initiation Factor)
6.	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
7.	Cuprizone
8.	Eukaryotic Initiation Factor-2 (EIF 2)
9.	Phosphotransferases (Kinase)
10.	Amino Acids

Related Therapies and Procedures

1.	Pneumonectomy (Lung Volume Reduction)
2.	Immunotherapy