|1.||Neubig, Richard R: 7 articles (06/2015 - 03/2002)|
|2.||Hooks, Shelley B: 6 articles (08/2015 - 01/2008)|
|3.||Traynor, John R: 5 articles (06/2015 - 07/2004)|
|4.||Hurst, Jillian H: 4 articles (01/2010 - 02/2008)|
|5.||Huang, Xinyan: 3 articles (06/2010 - 05/2007)|
|6.||Murph, Mandi M: 2 articles (08/2015 - 01/2010)|
|7.||Jutkiewicz, Emily M: 2 articles (06/2015 - 06/2010)|
|8.||Yang, Shuying: 2 articles (01/2015 - 03/2013)|
|9.||Li, Yi-Ping: 2 articles (01/2015 - 03/2013)|
|10.||Mende, Ulrike: 2 articles (07/2011 - 03/2006)|
03/03/2006 - "In this study, we report a marked decrease in RGS2 (but not other major cardiac RGS proteins (RGS3-RGS5)) that occurs prior to hypertrophy development in different models with enhanced G(q/11) signaling (transgenic expression of activated Galpha(q)(*) and pressure overload due to aortic constriction). "
10/01/2006 - "We investigated the potential role of RGS proteins on alpha1-adrenergic receptor signals associated with hypertrophy in primary cultures of neonatal rat cardiomyocytes. "
05/01/2004 - "This article reviews the role of G alpha q in the development of pressure overload hypertrophy and discusses the relationships between G alpha q and beta-adrenergic receptors, RGS proteins, and the proapoptotic factor, Nix/Bnip3L."
09/15/2004 - "These data provide the first evidence that RGS proteins may be important modulators of cancer risk and validate RGS6 as a target for further study."
06/01/2013 - "Together, these data suggest that (i) RGS proteins may have a combined and cell-specific role in a control of cancer cell function, and (ii) a given RGS protein may regulate the progression of various cancers through a common mechanism."
06/01/2013 - "Furthermore, significant changes in the expression of certain RGS proteins trended toward the same direction across various cancers. "
06/01/2013 - "We assessed if common trends might exist in the expression of various RGS proteins in several types of cancer by examining microarray data using the Oncomine database. "
06/01/2013 - "Increasing evidence suggest that the expression of certain RGS proteins is changed dramatically in various cancers, and in some instances, the control of cancer cell proliferation or migration by RGS proteins has been demonstrated. "
|3.||Parkinson Disease (Parkinson's Disease)
10/01/2003 - "In connection with the previously documented acute regulation of RGS proteins after modulation of the dopaminergic transmission [Geurts et al., Neurosci Lett 2002;333:146-50], the present study demonstrates that alteration in their genetic expression can be long-lasting and this could reflect the adaptation processes that occur in certain pathological states, such as Parkinson's disease."
06/17/2015 - "These results expand our understanding of the mechanism and specificity of TDZD RGS inhibitors and support the potential for therapeutic targeting of RGS proteins in Parkinson's disease and other neural disorders. "
06/17/2015 - "Regulators of G protein signaling (RGS) proteins, especially RGS4, play significant roles in epilepsy and Parkinson's disease. "
10/01/2014 - "Regulators of G-protein signalling (RGS) proteins are implicated in striatal G-protein coupled receptor (GPCR) sensitisation in the pathophysiology of l-DOPA-induced abnormal involuntary movements (AIMs), also known as dyskinesia (LID), in Parkinson's disease (PD). "
|4.||Ovarian Neoplasms (Ovarian Cancer)
01/01/2009 - "Thus, multiple RGS proteins are expressed at significantly different levels in cells derived from cancerous and normal ovarian cells and at least two candidate RGS transcripts have been identified to account for the reported regulation of LPA signalling pathways in ovarian cancer cells."
01/01/2009 - "We have recently reported that RGS proteins endogenously expressed in SKOV-3 ovarian cancer cells dramatically attenuate LPA stimulated cell signalling. "
02/01/2008 - "These data establish RGS proteins as novel regulators of LPA signaling in ovarian cancer cells."
02/01/2008 - "To determine the effect of endogenous RGS proteins on LPA signaling in ovarian cancer cells, we compared LPA activity in SKOV-3 ovarian cancer cells expressing G(i) subunit constructs that are either insensitive to RGS protein regulation (RGSi) or their RGS wild-type (RGSwt) counterparts. "
02/01/2008 - "Finally, LPA-stimulated SKOV-3 cell migration, as measured in a wound-induced migration assay, was enhanced in cells expressing Galpha(i2) RGSi as compared to cells expressing Galpha(i2) RGSwt, suggesting that endogenous RGS proteins in ovarian cancer cells normally attenuate this LPA effect. "
|5.||Sick Sinus Syndrome
01/01/2012 - "Together, these studies identify RGS proteins, especially RGS6, as new therapeutic targets for diseases such as sick sinus syndrome or other maladies involving abnormal autonomic control of the heart."
05/01/2007 - "Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block."
05/01/2007 - "The severe carbachol-induced sinus bradycardia in Galpha(i2)G184S mice suggests a possible role for alterations of Galpha(i2) or RGS proteins in sick sinus syndrome and pathological AV block."
|1.||GTP-Binding Proteins (G-Protein)
|2.||mu Opioid Receptors (mu Opioid Receptor)
|4.||GTPase-Activating Proteins (GTPase-Activating Protein)
|5.||Proteins (Proteins, Gene)
|6.||lysophosphatidic acid (MOPA)
|10.||GTP Phosphohydrolases (GTPases)
|1.||Drug Therapy (Chemotherapy)