cdc25 Phosphatases

A subclass of dual specificity phosphatases that play a role in the progression of the CELL CYCLE. They dephosphorylate and activate CYCLIN-DEPENDENT KINASES.

Also Known As:

Cell Division Cycle 25B protein; Dual Specificity Phosphatase Cdc25A; Dual Specificity Phosphatase Cdc25B; Dual Specificity Phosphatase Cdc25C; M-Phase Inducer Phosphatase 1; M-Phase Inducer Phosphatase 2; M-Phase Inducer Phosphatase 3; cdc25 Phosphatase; cdc25A Phosphatase; cdc25B Phosphatase; cdc25C Phosphatase; M Phase Inducer Phosphatase 1; M Phase Inducer Phosphatase 2; M Phase Inducer Phosphatase 3; Phosphatase, cdc25; Phosphatase, cdc25A; Phosphatase, cdc25B; Phosphatase, cdc25C; Phosphatases, cdc25

Networked: 109 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ducommun, Bernard: 6 articles (04/2009 - 01/2003)
2.	Lavecchia, Antonio: 5 articles (12/2020 - 12/2008)
3.	Bagrel, Denyse: 4 articles (04/2022 - 10/2011)
4.	Park, Hwangseo: 4 articles (08/2009 - 08/2008)
5.	Quaranta, Muriel: 4 articles (03/2009 - 01/2003)
6.	Carr, Brian I: 4 articles (10/2008 - 05/2003)
7.	Braud, Emmanuelle: 3 articles (12/2012 - 10/2008)
8.	Garbay, Christiane: 3 articles (12/2012 - 10/2008)
9.	Kolb, Stéphanie: 3 articles (12/2012 - 10/2008)
10.	Battaglia, Eric: 3 articles (10/2012 - 10/2011)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2009 - "Two-photon imaging of multicellular tumor spheroids: a novel method for evaluating the efficacy of CDC25 phosphatase inhibitors." 04/07/2022 - "Cdc25 phosphatases have been considered promising targets for anticancer development due to the correlation of their overexpression with a wide variety of cancers. " 09/01/2020 - "Cell division cycle 25 (CDC25) phosphatases, a kind of cell cycle regulators, have become an attractive target for drug discovery, as they have been found to be over-expressed in various human cancer cells. " 01/01/2019 - "CDC25 phosphatases play a critical role in the regulation of the cell cycle and thus represent attractive cancer therapeutic targets. " 07/07/2017 - "Cell division cycle phosphatases CDC25 A, B and C are involved in modulating cell cycle processes and are found overexpressed in a large panel of cancer typology. "
2.	Prostatic Neoplasms (Prostate Cancer) 07/01/2010 - "The antiproliferative efficacy of Cdc25 phosphatase inhibitor 7-chloro-6-(2-morpholin-4-ylethylamino) quinoline-5, 8-dione (DA 3003-2) was investigated in the PC-3 asynchronous human prostate cancer cell line using a cell-based assay. " 10/01/2011 - "Down-regulation of CK2 activity results in a decrease in the level of cdc25C phosphatase in different prostate cancer cell lines." 07/01/2005 - "Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer." 07/01/2010 - "In addition, overexpression of Cdc25 phosphatases in prostate cancer is correlated with disease progression. " 01/01/2004 - "These results indicate Cdc25A phosphatase regulates Raf-1/MEK/Erk kinase activation in human prostate cancer cells."
3.	Melanoma (Melanoma, Malignant) 01/01/2019 - "Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines." 12/01/2020 - "The dual phosphatases CDC25 are involved in cell cycle regulation and overexpressed in many tumours, including melanoma. " 03/01/2006 - "Two-dimensional electrophoresis in conjunction with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis or computer matching with a protein database further revealed that the MMTC-induced apoptosis is accompanied by increased levels of caspase-1, checkpoint suppressor-1, caspase-4, NF-kappaB inhibitor, AP-2, c-Jun-N-terminal kinase, melanoma inhibitor, granzyme K, G1/S specific cyclin D3, cystein rich protein, Ras-related protein Rab-37 or Ras-related protein Rab-13, and reduced levels of EMS (oncogene), ATP synthase, tyrosine-phosphatase, Cdc25c, 14-3-3 protein or specific structure of nuclear receptor. "
4.	Retinoblastoma (Glioblastoma, Retinal) 04/01/2015 - "These findings demonstrate an important role of CDC25 phosphatase proteins and inhibition of these proteins may have therapeutic potential in retinoblastoma." 04/01/2015 - "Expression of CDC25A and CDC25B phosphatase proteins in human retinoblastoma and its correlation with clinicopathological parameters." 05/01/2006 - "This study was designed to analyse, at messenger RNA (mRNA) level, cyclins and CDKs involved in the retinoblastoma pathway, as well as cell division cycle 25a phosphatase (CDC25a), which activates some of the CDKs that were analysed. "
5.	Glioma (Gliomas) 10/01/2010 - "This study evaluated the role of CDC25 phosphatases in human glioma proliferation. "

Related Drugs and Biologics

1.	Cyclins
2.	Messenger RNA (mRNA)
3.	Proteins (Proteins, Gene)
4.	Phosphotransferases (Kinase)
5.	Cyclin-Dependent Kinases (cdk Proteins)
6.	14-3-3 Proteins (14-3-3 Protein)
7.	Protein Isoforms (Isoforms)
8.	Cyclin B
9.	Cyclin A
10.	CDC2 Protein Kinase (Protein p34cdc2)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)