I-kappa B Proteins (I kappa B)

A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.

Also Known As:

Networked: 150 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dou, Q Ping: 3 articles (01/2008 - 07/2002)
2.	Zhang, Jun: 2 articles (03/2011 - 10/2003)
3.	Horwitz, Marshall S: 2 articles (03/2008 - 12/2005)
4.	Heneka, Michael T: 2 articles (01/2004 - 08/2002)
5.	Kazi, Aslamuzzaman: 2 articles (09/2003 - 07/2002)
6.	Smith, David M: 2 articles (09/2003 - 07/2002)
7.	Feinstein, Douglas L: 2 articles (08/2002 - 08/2002)
8.	Gao, Y: 2 articles (12/2001 - 08/2000)
9.	Li, M: 2 articles (12/2001 - 08/2000)
10.	Post, M J: 2 articles (12/2001 - 08/2000)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 01/01/2000 - "This is accomplished by inhibiting I kappa B degradation in endotoxin shock and this may prove useful for the treatment of endotoxin shock." 01/01/1998 - "The need for previous induction of I kappa B-alpha could provide a molecular explanation for the limited efficacy of these agents in the therapy of septic shock."
2.	Neoplasms (Cancer) 07/11/2016 - "In line with in vitro observations, western blot analysis revealed decreased phosphorylation of I-kappa-B-alpha in excised Lipo-EF24-treated xenograft tumor tissues. " 04/10/2008 - "In primary human keratinocytes transformed by Ras and I kappa B alpha, c-Myc increases the fraction of tumor-initiating cells by 150-fold, enabling tumor formation and serial propagation with as few as 500 cells. " 04/01/2004 - "Decreased I kappa B alpha expression correlated with high tumor grade (P = 0.015). " 11/01/1994 - "Our results raise the interesting possibility that I kappa B alpha represents a potential tumor suppressor activity." 07/01/2017 - "They were divided into cardia and non-cardia cancer in order to study a single-nucleotide polymorphism of the nuclear factor-κB signaling pathway important node molecules P50 and I kappa B encoding genes NFKB1 and NFKBIA by desorption ionization time of flight mass spectrometry analysis and by matrix-assisted laser mass spectrometry. "
3.	Infections 08/01/2003 - "In vitro colony-forming assays revealed that the overexpression of the stable I kappa B alpha by AxI kappa B alpha Delta N infection significantly suppressed cell growth after irradiation in both cell lines as compared to infection with a control vector, AxLacZ. " 11/03/2000 - "Last, we show that synthesis of I kappa B alpha is increased during ASFV infection, indicating RelA-independent transcription of the I kappa B alpha gene." 08/01/1999 - "The normal cell lines, although able to be successfully infected, did not show a significant decrease in cell viability or proliferation with adenoviral-mediated I kappa B alpha M infection. " 01/01/2005 - "To date, mutations in the extracellular domain of TLR4 itself, IRAK-4, NEMO (IKK gamma), and I kappa B alpha have been identified and profoundly affect the host response to infection." 06/01/2001 - "parvum triggers host cell apoptosis in bystander uninfected biliary epithelial cells, which may limit spread of the infection, it directly activates the NF-kappaB/I(kappa)B system in infected biliary epithelia thus protecting infected cells from death and facilitating parasite survival and propagation."
4.	Hypoxia (Hypoxemia) 02/15/1997 - "We show here that hypoxia, but not reoxygenation, induces the activation of NF-kappa B through the degradation of a major inhibitor of NF-kappa B, I kappa B alpha. " 10/15/1994 - "We postulate that Src activation by hypoxia may be one of the earliest events that precedes Ras activation in the signaling cascade which ultimately leads to the phosphorylation and dissociation of the inhibitory subunit of NF-kappa B, I kappa B alpha." 09/01/2001 - "In this study, we show that I kappa B alpha M expression inhibits stress-induced NF-kappa B activation and prevents BFA-, hypoxia-, and OA-induced resistance to etoposide. " 01/17/2003 - "Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation." 10/15/1994 - "We have previously shown that hypoxia causes the activation of nuclear factor-kappa B (NF-kappa B), and the phosphorylation of its inhibitory subunit, I kappa B alpha, on tyrosine residues. "
5.	Wounds and Injuries (Trauma) 07/01/2001 - "LPS did not induce I kappa B expression in PBMCs from trauma patients, but strong induction was obtained with staphylococci, suggesting that this defect is not universal and depends on the nature of the activating signal. " 07/01/2001 - "The ex vivo expression of I kappa B alpha was higher in PBMCs of controls than of trauma patients. " 11/01/2006 - "Mechanisms of microvascular wound repair I. Role of mitosis, oxygen tension, and I-kappa B." 03/01/2003 - "I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma." 07/01/2001 - "Long-term-impaired expression of nuclear factor-kappa B and I kappa B alpha in peripheral blood mononuclear cells of trauma patients."

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	Messenger RNA (mRNA)
5.	I-kappa B Kinase
6.	DNA (Deoxyribonucleic Acid)
7.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
8.	tax Gene Products (tax Gene Product)
9.	Collagen Type II (Type II Collagen)
10.	Casein Kinase II (Casein Kinase 2)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Lasers (Laser)
4.	Vagus Nerve Stimulation
5.	Stents