|1.||Dou, Q Ping: 3 articles (01/2008 - 07/2002)|
|2.||Zhang, Jun: 2 articles (03/2011 - 10/2003)|
|3.||Heneka, Michael T: 2 articles (01/2004 - 08/2002)|
|4.||Smith, David M: 2 articles (09/2003 - 07/2002)|
|5.||Kazi, Aslamuzzaman: 2 articles (09/2003 - 07/2002)|
|6.||Feinstein, Douglas L: 2 articles (08/2002 - 08/2002)|
|7.||Simons, M: 2 articles (12/2001 - 08/2000)|
|8.||Sato, K: 2 articles (12/2001 - 08/2000)|
|9.||Gao, Y: 2 articles (12/2001 - 08/2000)|
|10.||Post, M J: 2 articles (12/2001 - 08/2000)|
04/10/2008 - "In primary human keratinocytes transformed by Ras and I kappa B alpha, c-Myc increases the fraction of tumor-initiating cells by 150-fold, enabling tumor formation and serial propagation with as few as 500 cells. "
04/01/2004 - "Decreased I kappa B alpha expression correlated with high tumor grade (P = 0.015). "
11/01/1994 - "Our results raise the interesting possibility that I kappa B alpha represents a potential tumor suppressor activity."
04/01/2007 - "To establish that inhibition of Ad-mda7-mediated NF-kappaB activation results in enhanced tumor cell killing, H1299 cells that overexpress the dominant-negative I kappa B alpha (dnI kappa B alpha) were treated with Ad-mda7 in vitro. "
12/24/2004 - "Stable expression of a super-repressor form of I kappa B alpha (I kappa B alpha M) in the UTC cell line FRO results in enhanced sensitivity to drug-induced apoptosis, to the loss of the ability of these cells to form colonies in soft agar, and to induce tumor growth in nude mice. "
01/01/2000 - "This is accomplished by inhibiting I kappa B degradation in endotoxin shock and this may prove useful for the treatment of endotoxin shock."
06/01/1997 - "Effect of calpain inhibitor I, an inhibitor of the proteolysis of I kappa B, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat."
11/01/2005 - "In heat shock group the activity of NF-KappaB complexes was lower than that in brain edema group, and the expression of I-Kappa B alpha higher than that in brain edema group at corresponding time points. "
11/21/2001 - "These data suggest that heat shock influences expression of IL-12 through the I-kappa B/NF-kappa B pathway."
06/15/1997 - "We showed that yeast endogenous kinase cascades activated by pheromone, hypo- or hyperosmotic shock cannot modulate NF-kappa B activity in our system, and that the p38 human MAP kinase does not act directly on the p65/I kappa B alpha complex."
|3.||Septic Shock (Toxic Shock Syndrome)
01/01/1998 - "The need for previous induction of I kappa B-alpha could provide a molecular explanation for the limited efficacy of these agents in the therapy of septic shock."
06/01/1997 - "1. We compared the effects of calpain inhibitor I (inhibitor of the proteolysis of I kappa B and, hence, of the activation of nuclear factor kappa B (NF kappa B) and dexamethasone on (i) the circulatory failure, (ii) multiple organ dysfunction and (iii) induction of the inducible isoforms of nitric oxide (NO) synthase (iNOS) and cyclo-oxygenase (COX-2) in anaesthetized rats with endotoxic shock. "
08/01/2003 - "In vitro colony-forming assays revealed that the overexpression of the stable I kappa B alpha by AxI kappa B alpha Delta N infection significantly suppressed cell growth after irradiation in both cell lines as compared to infection with a control vector, AxLacZ. "
11/03/2000 - "Last, we show that synthesis of I kappa B alpha is increased during ASFV infection, indicating RelA-independent transcription of the I kappa B alpha gene."
08/01/1999 - "The normal cell lines, although able to be successfully infected, did not show a significant decrease in cell viability or proliferation with adenoviral-mediated I kappa B alpha M infection. "
08/01/1994 - "Furthermore, a virus-induced degradation of I kappa B alpha (MAD3) protein is observed between 2 and 8 h after infection; at later times, de novo synthesis of I kappa B alpha restores I kappa B alpha to levels found in uninduced cells and correlates with the down regulation of IFN-beta transcription. "
01/01/2005 - "To date, mutations in the extracellular domain of TLR4 itself, IRAK-4, NEMO (IKK gamma), and I kappa B alpha have been identified and profoundly affect the host response to infection."
02/15/1997 - "We show here that hypoxia, but not reoxygenation, induces the activation of NF-kappa B through the degradation of a major inhibitor of NF-kappa B, I kappa B alpha. "
10/15/1994 - "We postulate that Src activation by hypoxia may be one of the earliest events that precedes Ras activation in the signaling cascade which ultimately leads to the phosphorylation and dissociation of the inhibitory subunit of NF-kappa B, I kappa B alpha."
09/01/2001 - "In this study, we show that I kappa B alpha M expression inhibits stress-induced NF-kappa B activation and prevents BFA-, hypoxia-, and OA-induced resistance to etoposide. "
01/17/2003 - "Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation."
10/15/1994 - "We have previously shown that hypoxia causes the activation of nuclear factor-kappa B (NF-kappa B), and the phosphorylation of its inhibitory subunit, I kappa B alpha, on tyrosine residues. "
|1.||NF-kappa B (NF-kB)
|3.||Messenger RNA (mRNA)
|4.||I-kappa B Kinase
|5.||DNA (Deoxyribonucleic Acid)
|6.||tax Gene Products (tax Gene Product)
|7.||Collagen Type II (Type II Collagen)
|8.||Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
|9.||Casein Kinase II (Casein Kinase 2)
|10.||HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)
|1.||Drug Therapy (Chemotherapy)