Son of Sevenless Proteins (Son of Sevenless Protein)

A class of RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS that are genetically related to the Son of Sevenless gene from DROSOPHILA. Sevenless refers to genetic mutations in DROSOPHILA that cause loss of the R7 photoreceptor which is required to see UV light.

Also Known As:

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Baltanás, Fernando C: 1 article (01/2018)
2.	Bustelo, Xosé R: 1 article (01/2018)
3.	Calzada, Nuria: 1 article (01/2018)
4.	Fuentes-Mateos, Rocío: 1 article (01/2018)
5.	García-Navas, Rósula: 1 article (01/2018)
6.	Gómez, Carmela: 1 article (01/2018)
7.	Jimeno, David: 1 article (01/2018)
8.	Liceras-Boillos, Pilar: 1 article (01/2018)
9.	Lorenzo-Martín, L Francisco: 1 article (01/2018)
10.	Menacho-Marquez, Mauricio: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1993 - "Given the proposed role of Sos proteins in ras regulation, and the frequent occurrence of activated ras alleles in tumor cells, we were interested in determining whether the Sos genes may also be activated inappropriately by DNA rearrangement in tumor cells. " 01/01/2018 - "These observations underscore the essential role of Sos proteins in cellular proliferation and migration and support the consideration of these RasGEFs as potential biomarkers/therapy targets in Ras-driven epidermal tumors."
2.	Carcinogenesis 04/01/2000 - "These results suggest that the amplification of both Grb2 and SOS proteins plays an important role in the carcinogenesis of human bladder cancer."
3.	Renal Cell Carcinoma (Grawitz Tumor) 09/01/1997 - "The significance of Ras guanine nucleotide exchange factor, son of sevenless protein, in renal cell carcinoma cell lines."
4.	Urinary Bladder Neoplasms (Bladder Cancer) 04/01/2000 - "Significance of the Grb2 and son of sevenless (Sos) proteins in human bladder cancer cell lines." 04/01/2000 - "These results suggest that the amplification of both Grb2 and SOS proteins plays an important role in the carcinogenesis of human bladder cancer." 04/01/2000 - "On the other hand, expression of Grb2 and Sos proteins was substantially increased in all human bladder cancer cell lines examined in comparison with cultured normal urothelial cells, whether codon 12 of H-ras was mutated or not. " 04/01/2000 - "However, the significance of Grb2 and Sos proteins, which is related to EGF-triggered Ras activation, has not been elucidated in human bladder cancer. "

Related Drugs and Biologics

1.	ras Guanine Nucleotide Exchange Factors
2.	Biomarkers (Surrogate Marker)
3.	Epidermal Growth Factor (EGF)
4.	Codon (Codons)

Related Therapies and Procedures

1.	Therapeutics