|1.||Der, Channing J: 7 articles (06/2014 - 06/2002)|
|2.||Frost, Jeffrey A: 6 articles (12/2014 - 01/2009)|
|3.||Rossman, Kent L: 5 articles (06/2014 - 04/2005)|
|4.||Gutkind, J Silvio: 5 articles (11/2013 - 09/2002)|
|5.||Collard, John G: 5 articles (07/2006 - 09/2004)|
|6.||Hu, Bo: 4 articles (06/2015 - 08/2007)|
|7.||Cheng, Shi-Yuan: 4 articles (06/2015 - 08/2007)|
|8.||Carr, Heather S: 4 articles (09/2013 - 02/2013)|
|9.||Kawasaki, Yoshihiro: 4 articles (08/2013 - 02/2007)|
|10.||Akiyama, Tetsu: 4 articles (08/2013 - 02/2007)|
09/01/2007 - "Autoinhibition of the Rho guanine nucleotide exchange factor ASEF is relieved by interaction with the APC tumor suppressor. "
11/15/2015 - "Considering that Abl has been reported to phosphorylate the guanine nucleotide exchange factor Sos1, eliciting its Rac-guanine nucleotide exchange factor activity, and Rac regulates podosome formation in myeloid cells and invadopodia formation in cancer cells, we addressed whether Sos1 is implicated in podosome formation and function in macrophages. "
11/01/2015 - "Neuroepithelial transforming gene 1 (Net-1), a Ras homolog family member A-specific guanine nucleotide exchange factor, has been shown to be upregulated in several human cancer types. "
08/01/2015 - "Triple functional domain protein (TRIO) is an evolutionarily conserved Dbl family guanine nucleotide exchange factors (GEFs) involved in cell proliferation and progression of some types of cancer. "
04/10/2015 - "Crk SH3-domain-binding guanine nucleotide-releasing factor (C3G) is involved in multiple signaling pathways and it has opposite roles in different cancers. "
|3.||Breast Neoplasms (Breast Cancer)
05/01/2013 - "Previous studies established that stimulation of ErbB receptors in breast cancer cells activates Rac1 and enhances motility via the Rac-guanine nucleotide exchange factor P-Rex1. "
12/01/2014 - "Neuroepithelial transforming gene 1 (Net1) is a RhoA subfamily-specific guanine nucleotide exchange factor that is overexpressed in human breast cancer and is required for breast cancer cell migration and invasion. "
12/01/2013 - "We report here that the RhoA-specific guanine nucleotide exchange factor Syx is required for the polarity of actively migrating brain and breast tumor cells. "
09/10/2010 - "We reported previously that MyoGEF, a guanine nucleotide exchange factor, plays a role in regulating breast cancer cell polarization and invasion. "
06/05/2009 - "The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration."
|4.||Neoplasm Metastasis (Metastasis)
05/01/2014 - "In this study we assessed the role of T cell lymphoma invasion and metastasis (TIAM1), a guanine nucleotide exchange factor for RAC1, in RAC1 and NOX2 activation and the onset of mitochondrial dysfunction in in vitro and in vivo models of glucotoxicity and diabetes. "
06/15/2012 - "In this study, we investigated the role of the guanine nucleotide exchange factor Vav3 in prostate cancer progression and metastasis and found that Vav3 expression correlated positively with prostate cancer cell migration and invasion. "
09/26/2005 - "In this study, we show that the Rac-specific guanine nucleotide exchange factor Tiam1 (T-lymphoma invasion and metastasis) controls the cell polarity of epidermal keratinocytes. "
01/08/2015 - "Here, we demonstrate that SIRT1 and SIRT2 positively regulate the levels of Rac1-GTP and the activity of T-cell lymphoma invasion and metastasis 1 (TIAM1), a Rac guanine nucleotide exchange factor (GEF). "
12/01/2013 - "The Par complex (Par3, Par6, and PKCζ) controls cell polarity in part by recruiting the Rac-specific guanine nucleotide exchange factor T-lymphoma invasion and metastasis 1 (Tiam1) to specialized cellular sites, where Tiam1 promotes local Rac1 activation and cytoskeletal remodeling. "
09/01/2007 - "Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study)."
11/01/2015 - "Leukemia-associated Rho guanine-nucleotide exchange factor (GEF [LARG]), a RhoA GEF, is highly expressed in platelets and may constitute a major upstream activator of RhoA. "
01/01/2014 - "A subsequent yeast 2-hybrid screen identified LARG; Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (also known as Arhgef12), as a potential novel TELO2 interactor. "
01/01/2014 - "The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling."
01/01/2011 - "The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells."
|1.||Peptide Elongation Factor 1 (1, EF)
|2.||Hyaluronic Acid (Hyaluronan)
|3.||rho guanine nucleotide exchange factors (rhoGEF)
|4.||rho GTP-Binding Proteins (rho GTP-Binding Protein)
|5.||Proteins (Proteins, Gene)
|6.||GTPase-Activating Proteins (GTPase-Activating Protein)
|7.||Messenger RNA (mRNA)
|10.||rab GTP-Binding Proteins