Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)

Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.

Also Known As:

Guanine Nucleotide Exchange Factor; GDP Dissociation Factor; GDP Dissociation Stimulators; GDP-GTP Exchange Protein; Guanine-Nucleotide-Releasing Factor; Exchange Factors, GDP; Factors, GDP Exchange; Factors, GDP-GTP Reversing; GDP GTP Exchange Protein; GDP GTP Reversing Factors; Guanine Nucleotide Releasing Factor; Reversing Factors, GDP-GTP; GDP Exchange Factors; GDP-GTP Reversing Factors; Guanine Nucleotide Releasing Factors

Networked: 592 relevant articles (2 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        Rho Guanine Nucleotide Exchange Factors: 186
        Eukaryotic Initiation Factor-2B: 152
        ral Guanine Nucleotide Exchange Factor: 50
        ras Guanine Nucleotide Exchange Factors: 25
        T-Lymphoma Invasion and Metastasis-inducing Protein 1: 23
        Guanine Nucleotide-Releasing Factor 2: 19
        C9orf72 Protein: 12
        cytohesin-1: 6
        human RCC1 protein: 1
        Arabidopsis AT1G01960 protein
        Arabidopsis At3g43300 protein
        Arabidopsis BET5 protein
        Arabidopsis GNL1 protein
        Arabidopsis GNOM protein
        Arabidopsis MON1 protein
        Arabidopsis RopGEF1 protein
        Arabidopsis RopGEF10 protein
        Arabidopsis RopGEF12 protein
        Arabidopsis RopGEF2 protein
        Arabidopsis ROPGEF4 protein
        Arabidopsis RopGEF7 protein
        Arabidopsis RopGEF8 protein
        Arabidopsis Vps9a protein
        C elegans AGEF-1 protein
        C elegans BRIS-1 protein
        C elegans CGEF-1 protein
        C elegans Ect-2 protein
        C elegans exc-5 protein
        C elegans GBF-1 protein
        C elegans Glo-4 protein
        C elegans GRP-1 protein
        C elegans pxf-1 protein
        C elegans RABX-5 protein
        C elegans ran-3 protein
        C elegans REI-1 protein
        C elegans RHGF-1 protein
        C elegans RHGF-2 protein
        C elegans RIC-8 protein
        C elegans RPM-1 protein
        C elegans UIG-1 protein
        Dictyostelium darlin protein
        Drosophila ALS2 protein
        Drosophila CG9175 protein
        Drosophila Crag protein
        Drosophila Efa6 protein
        Drosophila Epac protein
        Drosophila Exn protein
        Drosophila garz protein
        Drosophila GEFmeso protein
        Drosophila Herc2 protein
        Drosophila Hfp protein
        Drosophila Pbl protein
        Drosophila PDZ-GEF protein
        Drosophila Pura protein
        Drosophila RCC1 protein
        Drosophila rhoGEF3 protein
        Drosophila RhoGEF4 protein
        Drosophila ric8a protein
        Drosophila sif protein
        Drosophila Siz protein
        Drosophila spri protein
        Drosophila Step protein
        Drosophila strat protein
        Drosophila trio protein
        Drosophila Vav protein
        Drosophila Zir protein
        human ALS2 protein
        human ALS2CL protein
        human ANKRD27 protein
        human ARFGEF1 protein
        human ARFGEF2 protein
        human ARFGEF3 protein
        human ARHGAP35 protein
        human ARHGEF15 protein
        human ARHGEF16 protein
        human ARHGEF19 protein
        human ARHGEF26 protein
        human ARHGEF28 protein
        human ARHGEF38 protein
        human ARHGEF40 protein
        human BCAR3 protein
        human CYTH4 protein
        human DEF6 protein
        human DENND1A protein
        human DENND1B protein
        human DENND1C protein
        human DENND2D protein
        human DENND3 protein
        human Dennd4C protein
        human DENND5A protein
        human DENND6A protein
        human DOCK10 protein
        human DOCK11 protein
        human DOCK2 protein
        human DOCK3 protein
        human Dock5 protein
        human DOCK6 protein
        human DOCK7 protein
        human DOCK8 protein
        human DOCK9 protein
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - GTP-Binding Protein Regulators
      - Guanine Nucleotide Exchange Factors: 592
        Rho Guanine Nucleotide Exchange Factors: 186
        Eukaryotic Initiation Factor-2B: 152
        ral Guanine Nucleotide Exchange Factor: 50
        ras Guanine Nucleotide Exchange Factors: 25
        T-Lymphoma Invasion and Metastasis-inducing Protein 1: 23
        Guanine Nucleotide-Releasing Factor 2: 19
        C9orf72 Protein: 12
        cytohesin-1: 6
        human RCC1 protein: 1
        Arabidopsis AT1G01960 protein
        Arabidopsis At3g43300 protein
        Arabidopsis BET5 protein
        Arabidopsis GNL1 protein
        Arabidopsis GNOM protein
        Arabidopsis MON1 protein
        Arabidopsis RopGEF1 protein
        Arabidopsis RopGEF10 protein
        Arabidopsis RopGEF12 protein
        Arabidopsis RopGEF2 protein
        Arabidopsis ROPGEF4 protein
        Arabidopsis RopGEF7 protein
        Arabidopsis RopGEF8 protein
        Arabidopsis Vps9a protein
        C elegans AGEF-1 protein
        C elegans BRIS-1 protein
        C elegans CGEF-1 protein
        C elegans Ect-2 protein
        C elegans exc-5 protein
        C elegans GBF-1 protein
        C elegans Glo-4 protein
        C elegans GRP-1 protein
        C elegans pxf-1 protein
        C elegans RABX-5 protein
        C elegans ran-3 protein
        C elegans REI-1 protein
        C elegans RHGF-1 protein
        C elegans RHGF-2 protein
        C elegans RIC-8 protein
        C elegans RPM-1 protein
        C elegans UIG-1 protein
        Dictyostelium darlin protein
        Drosophila ALS2 protein
        Drosophila CG9175 protein
        Drosophila Crag protein
        Drosophila Efa6 protein
        Drosophila Epac protein
        Drosophila Exn protein
        Drosophila garz protein
        Drosophila GEFmeso protein
        Drosophila Herc2 protein
        Drosophila Hfp protein
        Drosophila Pbl protein
        Drosophila PDZ-GEF protein
        Drosophila Pura protein
        Drosophila RCC1 protein
        Drosophila rhoGEF3 protein
        Drosophila RhoGEF4 protein
        Drosophila ric8a protein
        Drosophila sif protein
        Drosophila Siz protein
        Drosophila spri protein
        Drosophila Step protein
        Drosophila strat protein
        Drosophila trio protein
        Drosophila Vav protein
        Drosophila Zir protein
        human ALS2 protein
        human ALS2CL protein
        human ANKRD27 protein
        human ARFGEF1 protein
        human ARFGEF2 protein
        human ARFGEF3 protein
        human ARHGAP35 protein
        human ARHGEF15 protein
        human ARHGEF16 protein
        human ARHGEF19 protein
        human ARHGEF26 protein
        human ARHGEF28 protein
        human ARHGEF38 protein
        human ARHGEF40 protein
        human BCAR3 protein
        human CYTH4 protein
        human DEF6 protein
        human DENND1A protein
        human DENND1B protein
        human DENND1C protein
        human DENND2D protein
        human DENND3 protein
        human Dennd4C protein
        human DENND5A protein
        human DENND6A protein
        human DOCK10 protein
        human DOCK11 protein
        human DOCK2 protein
        human DOCK3 protein
        human Dock5 protein
        human DOCK6 protein
        human DOCK7 protein
        human DOCK8 protein
        human DOCK9 protein

Experts

1.	Hadano, Shinji: 13 articles (10/2021 - 07/2003)
2.	Otomo, Asako: 12 articles (10/2021 - 07/2003)
3.	Ikeda, Joh-E: 11 articles (03/2010 - 07/2003)
4.	Der, Channing J: 10 articles (01/2018 - 06/2002)
5.	Kunita, Ryota: 9 articles (03/2010 - 07/2003)
6.	Kazanietz, Marcelo G: 8 articles (11/2021 - 02/2012)
7.	Frost, Jeffrey A: 8 articles (01/2021 - 01/2009)
8.	Suzuki-Utsunomiya, Kyoko: 8 articles (11/2018 - 09/2004)
9.	Mizumura, Hikaru: 7 articles (05/2008 - 07/2003)
10.	Gutkind, J Silvio: 6 articles (10/2021 - 09/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2007 - "Autoinhibition of the Rho guanine nucleotide exchange factor ASEF is relieved by interaction with the APC tumor suppressor. " 12/05/2023 - "As a guanine nucleotide exchange factor, Son of Sevenless Homologue 1 (SOS1) represents a potential therapeutic concept for the treatment of KRAS-mutant cancers because of its activation on KRAS and downstream signaling pathways. " 04/30/2023 - "Finally, we found that the AS of the Rap Guanine Nucleotide Exchange Factor 6 (RapGEF6), a newly identified NOVA2 target, is altered in GC patients and associated with NOVA2 expression, tumor angiogenesis, and poor patient outcome. " 02/09/2023 - "The use of small molecular modulators to target the guanine nucleotide exchange factor SOS1 has been demonstrated to be a promising strategy for the treatment of various KRAS-driven cancers. " 01/01/2022 - "Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9), functioned as a tumor suppress factor in GC, was found as the downstream target of miR-514-3p, and their expressions were negatively correlated in GC tumor tissues. "
2.	Cysts 01/15/1988 - "The guanine nucleotide exchange factor, elongation factor 1 beta gamma (EF-1 beta gamma) has been purified from Artemia cysts using an improved method. " 10/07/2019 - "To explore the regulation of Rho GTPases in vivo, we analyzed the Rho GTPase guanine nucleotide exchange factor (RhoGEF) Cysts, the Drosophila orthologue of mammalian p114RhoGEF, GEF-H1, p190RhoGEF, and AKAP-13. "
3.	Neoplasm Metastasis (Metastasis) 03/27/2018 - "In this study, we aimed to investigate the roles and molecular mechanisms of Dock6, an atypical Rho guanine nucleotide exchange factor (GEF), in GC metastasis. " 01/01/2022 - "The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibrotic processes, cell migration, and metastasis. " 01/01/2020 - "In this perspective article we focus on the mechanisms leading to aberrant Rac1 signaling in NSCLC progression and metastasis, highlighting the role of Rac Guanine nucleotide Exchange Factors (GEFs). " 07/22/2022 - "In the current study, we found that Rho guanine nucleotide exchange factor 37 (ARHGEF37) was upregulated in human HCC samples and was associated with tumor invasiveness, pulmonary metastasis and poor prognosis. " 06/15/2012 - "In this study, we investigated the role of the guanine nucleotide exchange factor Vav3 in prostate cancer progression and metastasis and found that Vav3 expression correlated positively with prostate cancer cell migration and invasion. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "In NeuT mice, a preclinical model or Her2-positive breast cancer, we previously reported that p140Cap counteracts Her2-dependent breast cancer progression, associating with the specific Rac1 Guanine Nucleotide Exchange Factor, Tiam1, and limiting the activation of both Tiam1 and Rac1. " 12/01/2014 - "Neuroepithelial transforming gene 1 (Net1) is a RhoA subfamily-specific guanine nucleotide exchange factor that is overexpressed in human breast cancer and is required for breast cancer cell migration and invasion. " 12/01/2013 - "We report here that the RhoA-specific guanine nucleotide exchange factor Syx is required for the polarity of actively migrating brain and breast tumor cells. " 09/10/2010 - "We reported previously that MyoGEF, a guanine nucleotide exchange factor, plays a role in regulating breast cancer cell polarization and invasion. " 06/05/2009 - "The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration."
5.	Leukemia 09/01/2007 - "Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study)." 01/01/2016 - "Furthermore, the stimulatory effect of CCR2a and CCR2b and Gαq was sensitive to coexpression of the Gαq-interacting leukemia-associated Rho guanine nucleotide exchange factor. " 11/01/2015 - "Leukemia-associated Rho guanine-nucleotide exchange factor (GEF [LARG]), a RhoA GEF, is highly expressed in platelets and may constitute a major upstream activator of RhoA. " 01/01/2014 - "A subsequent yeast 2-hybrid screen identified LARG; Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (also known as Arhgef12), as a potential novel TELO2 interactor. " 01/01/2014 - "The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling."

Related Drugs and Biologics

1.	Peptide Elongation Factor 1 (EF-1)
2.	Proteins (Proteins, Gene)
3.	Hyaluronic Acid (Hyaluronan)
4.	Rho Guanine Nucleotide Exchange Factors
5.	GTPase-Activating Proteins (GTPase-Activating Protein)
6.	rho GTP-Binding Proteins (rho GTP-Binding Protein)
7.	Guanosine Triphosphate (GTP)
8.	Ligands
9.	ErbB Receptors (EGF Receptor)
10.	rab GTP-Binding Proteins

Related Therapies and Procedures

1.	Therapeutics
2.	Cardiopulmonary Resuscitation (CPR)
3.	Drug Therapy (Chemotherapy)
4.	Castration