HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Peptide Elongation Factor 2 (EF-2)

Peptide Elongation Factor 2 catalyzes the translocation of peptidyl-tRNA from the A site to the P site of eukaryotic ribosomes by a process linked to the hydrolysis of GTP to GDP.
Also Known As:
EF-2; EF 2; NSP 100; NSP100; 100, NSP; Cytoplasmic Elongation Factor 2; Elongation Factor 2
Networked: 92 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Davis, Teresa A: 3 articles (01/2014 - 08/2007)
2. Suryawan, Agus: 3 articles (01/2014 - 08/2007)
3. Nguyen, Hanh V: 3 articles (01/2014 - 08/2007)
4. Viollet, Benoit: 3 articles (06/2013 - 02/2007)
5. Fukuda, Mari: 2 articles (05/2014 - 05/2009)
6. Nakatsuka, Shin-Ichi: 2 articles (05/2014 - 05/2009)
7. Tatsumi, Naoya: 2 articles (05/2014 - 05/2009)
8. Fujiki, Fumihiro: 2 articles (05/2014 - 05/2009)
9. Fukuda, Ikuyo: 2 articles (05/2014 - 05/2009)
10. Nanchi, Isamu: 2 articles (05/2014 - 05/2009)

Related Diseases

1. Neoplasms (Cancer)
2. Hairy Cell Leukemia
3. Hypertrophy
09/01/2014 - "After TAC, all hypertrophic remodeling patterns known in human disease were observed: 1) low-flow, low-gradient with preserved ejection fraction (EF); 2) concentric hypertrophy with normal EF and flow; 3) concentric hypertrophy with moderately decreased EF and/or flow; 4) eccentric hypertrophy with normal EF and flow; 5) eccentric hypertrophy with moderately decreased EF and/or flow; and 6) eccentric hypertrophy with severely depressed EF. "
07/01/2009 - "This enhanced growth of AMPKalpha1-deficient muscle was accompanied by increased phosphorylation of mTOR signaling downstream targets and decreased phosphorylation of eukaryotic elongation factor 2. These results demonstrate that AMPKalpha1 plays an important role in limiting skeletal muscle overgrowth during hypertrophy through inhibition of the mTOR-signaling pathway."
01/01/2002 - "Hypertrophy under additional IGF-1 was combined with a shift of the EF-2 variants to basic subtypes (p < 0.01). "
08/01/2014 - "In this study, we aimed to investigate the role of ERK in translational control during CB-induced muscular hypertrophy by measuring time-dependent changes in the phosphorylation statuses of ERK, p70 ribosomal S6 kinase (p70S6K; an indicator of mTORC1 activity), 4E-binding protein 1 (4E-BP1), eukaryotic elongation factor 2 (eEF2), and other related signaling molecules in rat gastrocnemius muscles. "
02/01/2007 - "In kidney glomerular epithelial cells, high glucose (30 mM), but not equimolar mannitol, stimulated de novo protein synthesis and induced hypertrophy in association with increased phosphorylation of eukaryotic initiation factor 4E binding protein 1 and decreased phosphorylation of eukaryotic elongation factor 2, regulatory events in mRNA translation. "
4. Squamous Cell Carcinoma (Epidermoid Carcinoma)
5. AIDS-Related Complex (ARC)

Related Drugs and Biologics

1. Peptide Initiation Factors (Initiation Factor)
2. Protein Kinases (Protein Kinase)
3. Proteasome Endopeptidase Complex (Proteasome)
4. Ubiquitin
5. Caspase 3 (Caspase-3)
6. Double-Stranded RNA (RNA, Double Stranded)
7. Angiotensin II
8. Ribosomal Protein S6 Kinases (S6 Kinase)
9. 70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
10. Proteins (Proteins, Gene)

Related Therapies and Procedures

1. Denervation