Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)

Cellular DNA-binding proteins encoded by the sis gene (GENES, SIS). c-sis proteins make up the B chain of PLATELET-DERIVED GROWTH FACTOR. Overexpression of c-sis causes tumorigenesis.

Also Known As:

Platelet Derived Growth Factor B; Proto-Oncogene Products c-sis; Proto-Oncogene Protein sis; Proto-Oncogene Proteins sis; Proto Oncogene Products c sis; Proto Oncogene Protein sis; Proto Oncogene Proteins c sis; Proto Oncogene Proteins sis; Proto-Oncogene Proteins, sis; c sis Proteins; sis Proto Oncogene Proteins; sis, Proto-Oncogene Protein; sis, Proto-Oncogene Proteins; PDGFB; Platelet-Derived Growth Factor B; c-sis Proteins; sis Proto-Oncogene Proteins

Networked: 491 relevant articles (9 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Betsholtz, Christer: 10 articles (01/2020 - 08/2002)
2.	Fuller, Gregory N: 7 articles (05/2015 - 07/2007)
3.	Uhrbom, Lene: 6 articles (06/2022 - 09/2007)
4.	Holland, Eric C: 6 articles (01/2021 - 07/2004)
5.	Pedeutour, Florence: 6 articles (11/2018 - 04/2002)
6.	Pilotti, Silvana: 5 articles (07/2016 - 09/2007)
7.	Rao, Ganesh: 5 articles (05/2015 - 12/2010)
8.	Westermark, Bengt: 5 articles (06/2011 - 06/2005)
9.	Momota, Hiroyuki: 4 articles (09/2021 - 08/2005)
10.	Andrae, Johanna: 4 articles (01/2020 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/15/2023 - "Survival was only improved in PDGFB-driven GBM models, suggesting that tumor cell genotype influenced the immune TME. " 02/01/2008 - "Thus, Pdgfb-iCreER mice are a valuable research tool to manipulate endothelial cells in postnatal mice and study tumor angiogenesis." 01/15/1994 - "Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study." 11/28/2023 - "The synergy between these two effects endowed PDGFB@ZIF8-RGD with superior capabilities in reprogramming the "cold" TIME to a "hot" TIME, thereby initiating robust antitumor immunity and suppressing tumor growth. " 11/28/2023 - "PDGFB@ZIF8-RGD effectively induced tumor vascular normalization, which facilitated trafficking and infiltration of immune effector cells, including natural killer (NK) cells, M1-like macrophages and CD8+ T cells, into tumor microenvironment. "
2.	Wounds and Injuries (Trauma) 09/01/1999 - "Adenoviral-mediated gene transfer of platelet-derived growth factor-B overcame the ischemic defect in wound healing and offers promise in the treatment of chronic nonhealing wounds. " 02/01/2009 - "To investigate the biological function of platelet-derived growth factor B (PDGF-B) on the survival and proliferation of cat corneal endothelial cells so as to provide bases for further studies of its role in wound repair and its clinical application. " 07/01/2005 - "In this study, lentiviral vectors carrying the human platelet-derived growth factor B (PDGF-B) gene were used to treated diabetic mouse wounds. " 10/01/2003 - "In this study, mouse dermal fibroblasts retrovirally transduced with the human platelet-derived growth factor B (PDGF-B) gene were used to treat diabetic mouse wounds. " 05/01/2009 - "Clinical interest has been witnessed in the past for exogenous applications of platelet derived growth factor B (PDGF-B) in chronic nonhealing wounds. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2021 - "Overall, interaction between GCAR cells and vascular endothelial cells promotes angiogenesis and peritoneal metastasis of GC based on C/EBPβ-mediated PDGFB autocrine and paracrine signaling. " 01/01/2021 - "Moreover, secreted PDGFB promoted angiogenesis in metastases via activation of the MAPK/ERK signaling pathway in vascular endothelial cells. " 09/01/2019 - "SPARC activates the PI3K/AKT/PDGFB/PDGFRβ axis to promote proliferation and metastasis by OSCC cell lines. " 09/01/2019 - "Furthermore, SPARC promotes OSCC cells metastasis by regulating the expressions of PDGFB, PDGFRβ, p-PDGFRβ , and the PI3K/AKT pathway. " 01/01/2022 - "Given the increasingly appreciated importance of PDGFB-to-PDGFRβ signaling in breast cancer progression, specifically in promoting metastasis, we end by discussing how therapeutic targeting of PDGFB-to-PDGFRβ signaling holds great promise for improving current breast cancer treatment strategies."
4.	Breast Neoplasms (Breast Cancer) 05/03/2013 - "In the present study, we found that both HBXIP and PDGFB were highly expressed in breast cancer cell lines. " 05/03/2013 - "In function, HBXIP enhanced the proliferation of breast cancer cells through PDGFB in vitro. " 01/01/2022 - "Given the increasingly appreciated importance of PDGFB-to-PDGFRβ signaling in breast cancer progression, specifically in promoting metastasis, we end by discussing how therapeutic targeting of PDGFB-to-PDGFRβ signaling holds great promise for improving current breast cancer treatment strategies." 01/01/2021 - "SIGNIFICANCE: These studies reveal a previously unknown role for PDGFB-to-PDGFRβ paracrine signaling in the promotion of breast cancer brain metastases and support the prognostic and therapeutic clinical utility of this pathway for patients.See" 10/02/2012 - "In this study, we show that HIF-1 promotes lymphatic metastasis of breast cancer by direct transactivation of the gene encoding platelet-derived growth factor B (PDGF-B), which has proliferative and chemotactic effects on lymphatic endothelial cells. "
5.	Glioma (Gliomas) 12/01/2012 - "(18)F-SKI249380 is a PDGFR-selective tracer, which demonstrates improved delivery to PDGFB-driven high-grade gliomas and facilitates treatment planning when coupled with nanoformulations and quantitative PET imaging approaches." 09/01/2021 - "In this study, we showed that deficiency of GD3 synthase (GD3S, St8sia1) attenuated glioma progression and clinical and pathological features in a platelet-derived growth factor B-driven murine glioma model. " 07/10/2007 - "Thus, this study provides definitive evidence that IGFBP2 plays a key role in activation of the Akt pathway and collaborates with K-Ras or PDGFB in the development and progression of two major types of glioma." 04/06/2023 - "Corrigendum to: Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB-driven gliomas." 01/01/2023 - "PDGFB:APOBEC3C fusion in congenital diffuse high-grade glioma of the brainstem."

Related Drugs and Biologics

1.	Collagen
2.	Phosphotransferases (Kinase)
3.	Tyrosine (L-Tyrosine)
4.	SD-208
5.	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
8.	Proteins (Proteins, Gene)
9.	Intercellular Signaling Peptides and Proteins (Growth Factors)
10.	Platelet-Derived Growth Factor

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Microbubbles
4.	Tissue Expansion
5.	Stents