|1.||Zheng, Yi: 23 articles (01/2015 - 08/2002)|
|2.||Merajver, Sofia D: 15 articles (07/2015 - 01/2002)|
|3.||van Golen, Kenneth L: 15 articles (06/2015 - 01/2002)|
|4.||Khanna, Hemant: 14 articles (01/2015 - 03/2005)|
|5.||Swaroop, Anand: 13 articles (07/2015 - 03/2005)|
|6.||Der, Channing J: 13 articles (09/2014 - 06/2002)|
|7.||Taylor, Gregory A: 12 articles (10/2015 - 02/2004)|
|8.||Wright, Alan F: 11 articles (10/2015 - 05/2002)|
|9.||Li, Tiansen: 11 articles (07/2015 - 11/2002)|
|10.||Shu, Xinhua: 10 articles (10/2015 - 09/2005)|
01/01/2015 - "To date, while no clinically effective drugs targeting Rho GTPase signaling for cancer treatment are available, tool compounds and lead drugs that pharmacologically inhibit Rho GTPase pathways have shown promise. "
06/01/2015 - "Thus, this study provides new insights into the mechanisms that regulate the intricate activation states of Rho-family GTPases during extracellular matrix-dependent migration, revealing potential new targets for interfering with extracellular matrix-dependent cancer cell migration. "
12/01/2014 - "This review describes advances in the development of small-molecule inhibitors aimed at modulating the Rho-GTPase-centric regulatory pathways governing motility, many of which stem from studies of cancer invasiveness. "
07/14/2014 - "Two recent studies have identified highly recurrent mutations of the gene encoding the small GTPase RhoA and suggest that RhoA activity may have a tumor suppressive role in this disease. "
01/01/2012 - "In this study we analyzed the expression of the GTPases Rac1, RhoA, Cdc42, and the Rho-GEFs, Tiam1 and beta-Pix, in cervical pre-malignant lesions and cervical cancer cell lines. "
08/01/2013 - "In the present study our aim was to investigate whether the GTPase Rac1 was an upstream signal that led to the activation of MEK/ERK1/2, JNK1/2 or Akt pathways upon VACV or CPXV' infections. "
03/01/2009 - "Therefore, our study revealed a completely novel aspect of Ran GTPase in phagocytosis by the direct interaction with the cytoskeleton protein and presented a novel pathway concerning to antiviral immunity, which will help to better understand the molecular events in immune response against virus infection in invertebrates."
03/01/2009 - "In our study, it was found that the Ran GTPase (designated as PjRan) was up-regulated in virus-resistant shrimp, indicating that the PjRan might be implicated in the innate immune system against virus infection. "
09/01/2008 - "Combining confocal microscopy with biochemical analysis and studies of infection requirements using pharmacological inhibitors and small interfering RNAs, we show here that engagement of CD81 activates the Rho GTPase family members Rac, Rho, and Cdc42 and that the block of these signaling pathways drastically reduces HCV infectivity. "
01/01/2008 - "Therefore, our study presents a novel Rab-dependent signaling complex, in which the Rab GTPase might detect virus infection as an intracellular virus recognition protein and trigger downstream phagocytic defense against virus in crustacean for the first time. "
01/15/2013 - "The aim of the present study was to analyse the role of these GTPases in regulating endothelial barrier function during hypoxia-reoxygenation in cultured porcine aortic endothelial cells and isolated perfused rat hearts. "
10/01/2011 - "In the present study, we examined the effects of hypoxia and the potential role of the GTPase RhoA and HIF-1α (hypoxia-inducible factor 1α) on MSC migration. "
04/30/2015 - "We investigated whether Tβ4 could play as an intermediary to crosstalk between Rac1- and Rap1- GTPase activation under hypoxia/reoxygenation (H/R) conditions. "
04/01/2014 - "Double deletions of the genes encoding Rho GTPase Cdc42 and Cdc420, but not of the genes encoding Rac1 and Rac2, caused a slight growth retardation in hypoxia. "
01/01/2014 - "Finally, the Gα-coupled receptor GTPase RGS1 was identified as a HIF-dependent hypoxia target that dampens SDF1-induced migration and signal transduction in human CD34+ stem/progenitor cells. "
09/01/2009 - "Spatial cues, such as bud scars and pheromone gradients, orient cell polarity by modulating the regulation of the Cdc42 GTPase cycle, thereby biasing the site of asymmetry amplification."
08/01/2009 - "Wasp and Scar/WAVE, the two founding members of the family, are regulated by the GTPases Cdc42 and Rac, respectively. "
09/15/2003 - "Lamellae are initiated by parallel and partially redundant signaling pathways involving Rac GTPases and the adaptor protein Nck, which stimulate SCAR, an Arp2/3 activator. "
09/02/2003 - "WASP binds directly to Cdc42 through its GTPase binding domain (GBD), but SCAR does not contain a GBD, and no direct binding has been found. "
01/01/2012 - "Focussing on genes in the latter class, RNAi-mediated knockdown of the small GTPase Rab5, the prenylated SNARE protein YKT6, one sub-unit of serine palmitoyltransferase (spt2/lace), the Rac1-associated protein Sra1 and the actin cytoskeleton regulatory protein, SCAR, all lead to a significant reduction in parasite phagocytosis. "
|5.||Neoplasm Metastasis (Metastasis)
07/15/2005 - "Restoration of one of these GTPases, deleted in liver cancer-1 (DLC-1), in metastatic M4A4 cells to levels observed in the nonmetastatic NM2C5 cell line resulted in the inhibition of migration and invasion in vitro and a significant reduction in the ability of these cells to form pulmonary metastases in athymic mice. "
03/15/2013 - "In this study, we identified the small GTPase Rab25 as a key regulator of HNSCC metastasis. "
11/20/2014 - "The Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis. "
06/01/2014 - "Evidence implicating the protein deleted in liver cancer-1 (DLC1), a Rho GTPase activator, in metastasis has accumulated to a point where DLC1 may be considered as a metastasis suppressor gene. "
03/01/2014 - "We identified the small GTPase RHOB as a gene that promotes early and late stages of metastasis in ADC. "
|2.||Proteins (Proteins, Gene)
|5.||rho GTP-Binding Proteins (rho GTP-Binding Protein)
|7.||Matrix Metalloproteinase 14 (MT1-MMP)
|2.||Heterologous Transplantation (Xenotransplantation)
|4.||Homologous Transplantation (Allograft)
|5.||Transplantation (Transplant Recipients)