Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)

A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1).
Also Known As:
Lymphoma, Mantle Cell; Lymphoma, Mantle-Cell; Diffuse Lymphocytic Lymphoma, Poorly-Differentiated; Lymphocytic Lymphoma, Diffuse, Poorly Differentiated; Centrocytic Small-Cell Lymphoma; Centrocytic Small-Cell Lymphomas; Diffuse Lymphocytic Lymphoma, Poorly Differentiated; Lymphoma, Centrocytic Small Cell; Lymphoma, Mantle-Zone; Lymphomas, Centrocytic Small-Cell; Lymphomas, Mantle-Cell; Lymphomas, Mantle-Zone; Mantle Cell Lymphoma; Mantle Zone Lymphoma; Mantle-Cell Lymphomas; Mantle-Zone Lymphomas; Small-Cell Lymphoma, Centrocytic; Small-Cell Lymphomas, Centrocytic; Lymphocytic Lymphoma, Diffuse, Poorly-Differentiated; Lymphoma, Centrocytic Small-Cell; Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated; Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated; Lymphoma, Lymphocytic, Intermediate; Lymphoma, Small-Cell, Centrocytic; Mantle-Zone Lymphoma
Networked: 1519 relevant articles (121 outcomes, 239 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Lymphoma (Lymphomas)
2. Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
3. Non-Hodgkin Lymphoma (Lymphosarcoma)
4. Neoplasms (Cancer)
5. Multiple Myeloma


1. Dreyling, Martin: 43 articles (11/2015 - 02/2003)
2. Campo, Elias: 27 articles (08/2015 - 01/2002)
3. Wang, Michael: 24 articles (06/2014 - 02/2005)
4. Colomer, Dolors: 23 articles (11/2015 - 11/2004)
5. Medeiros, L Jeffrey: 22 articles (09/2013 - 05/2002)
6. Hiddemann, Wolfgang: 20 articles (02/2015 - 02/2003)
7. Lai, Raymond: 20 articles (08/2013 - 12/2002)
8. Rosenwald, Andreas: 19 articles (11/2015 - 11/2005)
9. Kahl, Brad S: 18 articles (09/2015 - 10/2005)
10. Ott, German: 17 articles (11/2015 - 10/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mantle-Cell Lymphoma:
1. rituximab (Mabthera)FDA Link
2. bortezomib (Velcade)FDA Link
3. Cyclophosphamide (Cytoxan)FDA LinkGeneric
4. bendamustineFDA Link
5. lenalidomide (CC 5013)FDA Link
6. Cytarabine (Cytosar-U)FDA LinkGeneric
7. Vincristine (Oncovin)FDA LinkGeneric
8. Doxorubicin (Adriamycin)FDA LinkGeneric
9. Proteasome Endopeptidase Complex (Proteasome)IBA
10. Prednisone (Sone)FDA LinkGeneric
03/01/2009 - "In spite of the general poor prognosis of mantle cell lymphoma, our patient had a good clinical and endoscopic response to the standard cyclophosphamide, vincristine, prednisone (CVP) therapy. "
03/05/2015 - "In this phase 3 trial, we randomly assigned 487 adults with newly diagnosed mantle-cell lymphoma who were ineligible or not considered for stem-cell transplantation to receive six to eight 21-day cycles of R-CHOP intravenously on day 1 (with prednisone administered orally on days 1 to 5) or VR-CAP (R-CHOP regimen, but replacing vincristine with bortezomib at a dose of 1.3 mg per square meter of body-surface area on days 1, 4, 8, and 11). "
03/01/2008 - "The prednisone, etoposide, procarbazine and cyclophosphamide (PEP-C) oral combination chemotherapy regimen (prednisone 20 mg, cyclophosphamide 50 mg, etoposide 50 mg, and procarbazine 50 mg with an oral anti-emetic) was employed at our center to treat 22 patients with heavily pretreated, recurrent mantle cell lymphoma (MCL). "
02/01/2006 - "The purpose of this study was to compare the efficacy and toxicity of bendamustine, vincristine + prednisone (BOP) with a standard regimen of cyclophosphamide, vincristine + prednisone (COP) in patients with previously untreated advanced indolent non-Hodgkin's lymphoma (NHL) and mantle cell lymphoma. "
02/01/2006 - "Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: results of a randomised phase III trial (OSHO# 19)."

Therapies and Procedures

1. Stem Cell Transplantation
2. Drug Therapy (Chemotherapy)
3. Transplants (Transplant)
4. Transplantation (Transplant Recipients)
5. Autologous Transplantation