|2.||Brain Ischemia (Cerebral Ischemia)
|5.||Wounds and Injuries (Trauma)
|1.||Igarashi, Kazuei: 13 articles (01/2015 - 04/2009)|
|2.||Kashiwagi, Keiko: 11 articles (12/2013 - 04/2009)|
|3.||Amarenco, Pierre: 10 articles (07/2013 - 04/2003)|
|4.||Iida, Mitsuo: 9 articles (04/2013 - 02/2005)|
|5.||Chen, Tsung-Ying: 9 articles (02/2012 - 06/2002)|
|6.||Labreuche, Julien: 8 articles (07/2013 - 08/2004)|
|7.||Lee, E-Jian: 8 articles (02/2012 - 06/2002)|
|8.||Ibayashi, Setsuro: 8 articles (12/2009 - 02/2005)|
|9.||Kitazono, Takanari: 7 articles (11/2012 - 02/2005)|
|10.||Wu, Tian-Shung: 7 articles (04/2011 - 06/2002)|
|1.||Tacrolimus (Prograf)FDA LinkGeneric
10/01/2002 - "Intravenous administration of tacrolimus or t-PA dose-dependently reduced the volume of ischemic brain infarction, whether administered immediately or 1 hour after MCA occlusion. "
03/07/2003 - "Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. "
03/19/2004 - "In permanent focal cerebral ischemia, we investigated whether FK506 caused remission of brain infarction, and how mechanism was concerned. "
10/01/2003 - "In conclusion, we have provided compelling evidence that a single dose of tacrolimus not only reduces brain infarction but also ameliorates long-term neurologic deficits in a nonhuman primate model of stroke, strengthening the view that tacrolimus might be beneficial in treating stroke patients."
10/01/2002 - "The authors evaluated the therapeutic efficacy of tacrolimus (FK506), administered alone or in combination with recombinant tissue plasminogen activator (t-PA), on brain infarction following thrombotic middle cerebral artery (MCA) occlusion. "
04/01/2011 - "Relative to vehicle-injected controls, melatonin given intravenously at 1-5 mg/kg, but not 0.1 or 15 mg/kg, significantly reduced brain infarction and improved neurobehavioral outcomes (P<0.05, respectively) in reproductively active female rats. "
01/01/2014 - "Melatonin-treated MSCs (MT-MSCs) further reduced brain infarction and improved neurobehavioral outcomes. "
04/01/2007 - "This melatonin-mediated decrease in the cellular inflammatory response was accompanied by both reduced brain infarction and improved neurobehavioral outcome by 43% (P < 0.001) and 50% (P < 0.001), respectively. "
04/01/2006 - "Additionally, we found that at 6 hr after photo-irradiation, either t-PA or melatonin, or a combined administration of t-PA plus melatonin, did not significantly affect brain infarction (P > 0.05), compared with controls. "
11/01/2010 - "Relative to controls, melatonin-treated animals had significantly decreased MMP-9 activity and expression (P<0.05), in addition to reduced brain infarction and hemorrhagic transformation as well as improved laminin protein preservation. "
07/01/2005 - "Efficacy of edaravone, a free radical scavenger, for the treatment of acute lacunar infarction."
01/01/2009 - "This study investigated the effect of edaravone on the outcome of patients with acute lacunar infarction. "
01/01/2011 - "Edaravone (MCI-186) is a potent free radical scavenger used clinically to treat acute brain infarction. "
05/22/2010 - "Since 1O2 is possibly involved in post-ischemic neuronal damage, the clinically approved curative effects of edaravone on acute brain infarction might be attributed to its potent 1O2 scavenging activity."
01/01/2009 - "The free radical scavenger 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone) has been used to treat acute brain infarction in Japan since 2001. "
|4.||cilostazol (Pletal)FDA LinkGeneric
01/01/2014 - "The ECLIPse study was a multicenter, randomized, double-blind, placebo-controlled trial that evaluated the difference between the efficacy of cilostazol and a placebo to reduce the PI in patients with acute lacunar infarction using serial TCD examinations. "
01/01/2014 - "The aim of the present study was to perform a subgroup analysis of the ECLIPse study in order to explore the effect of cilostazol in acute lacunar infarction based on cerebral white matter hyperintensities (WMH) volume. "
01/01/2014 - "The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of the Transcranial Doppler (ECLIPse) study showed a significant decrease in the transcranial Doppler (TCD) pulsatility index (PI) with cilostazol treatment at 90 days after acute lacunar infarction. "
01/01/2014 - "Cilostazol decreases cerebral arterial pulsatility in patients with mild white matter hyperintensities: subgroup analysis from the Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) study."
01/01/2013 - "This study is intended to evaluate the propensities of cilostazol to reduce the pulsatility index (PI) in patients with acute lacunar infarction using the serial transcranial Doppler (TCD) examinations. "
|5.||glucuronyl glucosamine glycan sulfate (Vessel)IBA
07/01/2001 - "Silent brain infarction on MRI was defined as a focal high intensity area on T2-weighted images larger than 3 mm. The prevalence of MRA lesions was significantly greater in the two- and three-vessel group than in the zero- and one-vessel group(53% vs 14%, p < 0.01). "
09/01/2011 - "The aim of this study was to evaluate the correlation between carotid siphon (CS) calcification and lacunar infarction caused by small-vessel disease. "
09/15/2008 - "The association between renal dysfunction and asymptomatic lacunar infarction was reported in a hospital-based study, whereas the relationship between cerebral small vessel disease (SVD)-related lesions and CKD could not be clarified in a community-based study. "
03/01/2015 - "Use of lacunar infarction as a marker of small vessel disease."
01/01/2015 - "Deep pontine lacunar infarction (DPLI) not involving the basal pial surface of the medial part of the pons, is known to be a small vessel disease in the territory of the basilar artery (BA). "
|6.||Tissue Plasminogen Activator (Alteplase)FDA Link
12/01/2013 - "Treatment with tissue plasminogen activator (tPA) is the most effective treatment in acute brain infarction. "
02/01/2009 - "Intravenous administration of recombinant tissue plasminogen activator (rt-PA) is a contraindicant therapy in patients of brain infarction with aortic dissection. "
11/01/2008 - "Because use of intravenous administration of tissue plasminogen activator (IV-t-PA) for acute brain infarction within 3 hours of onset has been approved by Japanese government from October, 2005. "
09/01/2007 - "Treatment of acute ischemic brain infarction with the assistance of local intraarterial thrombolysis with recombinant tissue-type plasminogen activator."
08/01/2010 - "The Kringle-2 domain of tissue plasminogen activator significantly reduces mortality and brain infarction in middle cerebral artery occlusion rats."
|7.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/01/2015 - "SBIs are associated with favorable outcomes in patients with first-ever acute lacunar infarction and higher levels of VEGF, and lower levels of SDF-1α in these patients may contribute to their more favorable prognosis."
02/01/2014 - "We conclude that, under the right treatment conditions, PROG treatment delayed up to 6 hours can improve functional deficits and reduce brain infarction, possibly by modulating GFAP, VEGF, and MMP-9 expression. "
06/01/2007 - "Vascular endothelial growth factor (VEGF) is also known as a potent vascular permeability factor and may play detrimental roles at the acute stage of brain infarction. "
02/09/2007 - "These findings show that implantation of PDMS-TEOS scaffold with VEGF might be effective for treating old brain infarction or trauma."
03/01/2015 - "Increased VEGF and decreased SDF-1α in patients with silent brain infarction are associated with better prognosis after first-ever acute lacunar stroke."
12/01/2015 - "We found that pretreatment with tropisetron significantly improved neurological deficits and diminished leukocyte transmigration into the brain, TNF-α level, and brain infarction in a murine model of embolic stroke. "
05/25/2011 - "Forty-eight hours after embolization, tropisetron (1 or 3mg/kg), tropisetron (3mg/kg) plus mCPBG (15 mg/kg), tacrolimus (1mg/kg), or tacrolimus (1mg/kg) plus tropisetron (3mg/kg) significantly curtailed brain infarction, improved behavioral scores, diminished elevated tissue MPO activity, and reduced TNF-α levels compared to control group (n=6; P<0.05). "
07/01/1989 - "The results of the study have shown significant reduction of the total HDL cholesterol levels in both subfractions, and especially of HDL3 in patients with brain infarction. "
01/01/2015 - "The aim of this study was to evaluate the association between high-density lipoprotein cholesterol (HDLC) levels and the risk of lacunar infarction (LI) in a retrospective cohort study in China. "
01/01/2015 - "Participants in this study had an increased ratio of silent brain infarction compared with Japanese healthy controls, accompanied with higher ratios of diabetes and low HDL cholesterol."
07/01/1989 - "Aiming to detect the most sensitive markers of increased risk of ischemic cerebrovascular diseases HDL, HDL2 and HDL3 cholesterol levels were examined using the ultracentrifugation method in 36 patients with acute brain infarction and 34 healthy subjects of the control group. "
02/01/2013 - "S-HDL and M-HDL cholesterol levels were inversely associated with total stroke risk, ischemic stroke, specifically lacunar infarction, and hemorrhagic stroke. "
|10.||Mannitol (Osmitrol)FDA LinkGeneric
02/01/1984 - "This experimental study was designed to develop more effective method in suppressing brain infarction than the combined treatment of mannitol and PFC. "
01/01/1983 - "A new therapy for acute brain infarction: revascularization following the administration of mannitol and perfluorochemicals."
12/01/1982 - "[Development of a new therapeutic method of brain infarction in the acute period: revascularization under the administration of mannitol and perfluorochemicals]."
05/01/1982 - "A new therapeutic method for acute brain infarction: revascularization following the administration of mannitol and perfluorochemicals--a preliminary report."
07/01/1981 - "[Development of new methods in suppressing brain infarction--combined administration of mannitol and perfluorochemicals (author's transl)]."
|1.||Transplantation (Transplant Recipients)
04/01/2010 - "Compared with PBS controls, rats receiving MSC transplantation showed improved functional recovery and reduced brain infarction volume at 7 and 14 days after MCAO. "
06/01/2015 - "Within 6 weeks, large numbers of SPIO-labeled BMSCs reached the lacunar infarction area from the transplantation region through the corpus callosum. "
04/15/2013 - "BMSC transplantation could reduce the infarct size (P<0.05) and improve functional deficits (P<0.001) in brain infarction. "
01/01/1994 - "Functional recovery after brain infarction: plasticity and neural transplantation."
07/01/2014 - "Brain infarction and neurologic deficits were attenuated after NSC transplantation in both aged and young-adult rats. "
01/01/1994 - "Brain infarction was produced by bilateral carotid ligation in 15, unilateral microcoagulation of the middle cerebral artery in 15 and by microcoagulation of the vertebral artery at the craniocervical junction in the other 15. "
02/01/2004 - "When brain infarction was established by extended aortic dissection in emergent aortic surgery, concomitant ligature of the responsible artery to the brain infarction may be allowed for avoiding cerebral damage leading to brain death."
05/01/1978 - "It was found that the volume of brain infarction in the group receiving pentobarbital 2 hrs after ligation was significantly less than that of the control group, which received no pentobarbital; but the volume of infarction in the former group was significantly greater than that found in the experimental group, which received pentobarbital prior to ligation. "
02/01/1992 - "We studied the role of endogenous reduced glutathione (GSH) in brain infarction associated with focal cerebral ischemia caused by permanent ligation of the right middle cerebral artery (MCA) and the right common carotid artery (CCA) plus temporary occlusion of the left CCA. "
06/04/2004 - "We have previously demonstrated that pretreatment with bone morphogenetic protein 7 (BMP7), a trophic factor in the TGFbeta superfamily, reduces ischemia-induced brain infarction induced by middle cerebral artery ligation in rats. "
|4.||Acupuncture Points (Acupuncture Point)
04/01/2005 - "The frequency of brain infarction complications was significantly higher in the patients with pronounced redundant catheter looping in the aortic arch than in patients with minimal pronounced redundant catheter looping (P = .044, Fisher exact test). "
04/01/2005 - "In contrast, brain infarctions occurred in only three of the 115 patients with minimal redundant catheter looping (2.6%). "
04/01/2005 - "Among the 33 patients with pronounced redundant catheter looping, brain infarctions occurred in four cases (12.1%). "
10/01/2002 - "In 5 patients (5.6%) brain infarction occurred after port-catheter implantation. "
10/01/2002 - "Brain infarction after percutaneous implantation of port-catheter system via the left subclavian artery."