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Hypokalemic Periodic Paralysis (Periodic Paralysis, Hypokalemic)

An autosomal dominant familial disorder characterized by recurrent episodes of skeletal muscle weakness associated with falls in serum potassium levels. The condition usually presents in the first or second decade of life with attacks of trunk and leg paresis during sleep or shortly after awakening. Symptoms may persist for hours to days and generally are precipitated by exercise or a meal high in carbohydrates. (Adams et al., Principles of Neurology, 6th ed, p1483)
Also Known As:
Periodic Paralysis, Hypokalemic; Hypokalemic Periodic Paralysis, Familial; Periodic Paralysis- Hypokalemic; Periodic Paralysis Hypokalemic; Periodic Paralysis- Hypokalemics; Familial Hypokalemic Periodic Paralysis; Paralysis, Hypokalemic Periodic; Primary Hypokalemic Periodic Paralysis
Networked: 228 relevant articles (8 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Paralysis (Palsy)
2. Myotonia
3. Channelopathies
4. Thyrotoxicosis
5. Muscle Weakness

Experts

1. Lin, Shih-Hua: 7 articles (05/2014 - 01/2003)
2. Jurkat-Rott, Karin: 7 articles (01/2014 - 11/2006)
3. Cannon, Stephen C: 6 articles (08/2014 - 07/2007)
4. Lehmann-Horn, Frank: 6 articles (01/2014 - 11/2006)
5. Fontaine, Bertrand: 5 articles (04/2010 - 01/2008)
6. Meola, G: 5 articles (05/2009 - 01/2003)
7. Kim, June-Bum: 4 articles (10/2014 - 01/2010)
8. Mi, Wentao: 4 articles (08/2014 - 10/2011)
9. Maciel, Rui M B: 4 articles (11/2010 - 11/2002)
10. Kim, Sung-Jo: 3 articles (10/2014 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypokalemic Periodic Paralysis:
1. PotassiumIBA
2. Acetazolamide (Diamox)FDA LinkGeneric
3. Carbonic Anhydrases (Carbonic Anhydrase)IBA
4. Dichlorphenamide (Daranide)FDA Link
5. Mexiletine (Mexitil)FDA LinkGeneric
6. Nondystrophic myotoniaIBA
7. Arginine (L-Arginine)FDA Link
8. Cromakalim (Levcromakalim)IBA
9. Adrenergic Antagonists (Antiadrenergic Agents)IBA
10. PropylthiouracilFDA Link

Therapies and Procedures

1. Thymectomy
2. Intravenous Infusions
3. Orthopedic Procedures
4. Injections
5. Drug Therapy (Chemotherapy)