Abducens Nerve Diseases (Sixth Nerve Palsy)

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107 relevant articles (5 outcomes, 7 trials/studies) found for this Disease

Description: Diseases of the sixth cranial (abducens) nerve or its nucleus in the pons. The nerve may be injured along its course in the pons, intracranially as it travels along the base of the brain, in the cavernous sinus, or at the level of superior orbital fissure or orbit. Dysfunction of the nerve causes lateral rectus muscle weakness, resulting in horizontal diplopia that is maximal when the affected eye is abducted and ESOTROPIA. Common conditions associated with nerve injury include INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; ISCHEMIA; and INFRATENTORIAL NEOPLASMS.

Also Known As:

Sixth Nerve Palsy; Abducens Nerve Palsy; Benign Recurrent Abducens Palsy of Childhood; Benign Recurrent Abducens Palsy, Children; Sixth Cranial Nerve Diseases; Sixth Cranial Nerve Palsy; VIth Cranial Nerve Diseases; Abducens Nerve Disease; Abducens Nerve Palsies; Lateral Rectus Palsies; Palsies, Abducens Nerve; Palsies, Lateral Rectus; Palsies, Sixth Nerve; Palsy, Abducens Nerve; Palsy, Lateral Rectus; Palsy, Sixth Nerve; Sixth Nerve Palsies; Abducens Palsy, Childhood, Benign Recurrent; Cranial Nerve VI Diseases; Lateral Rectus Palsy; Sixth Cranial Nerve Disorders

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3406

Cranial Nerve Diseases: 147

Abducens Nerve Diseases: 107

Abducens Nerve Injury: 4

Related Diseases

1.	Paralysis (Palsy)
2.	Strabismus (Squint)
3.	Migraine Disorders (Migraine)
4.	Arachnoid Cysts (Arachnoid Cyst)
5.	Esotropia (Esophoria)

Experts

1.	Gandhi, Dheeraj: 1 article (09/2008)
2.	Trobe, Jonathan: 1 article (09/2008)
3.	Gujar, Sachin: 1 article (09/2008)
4.	Jacob, Maud: 1 article (09/2008)
5.	Tanriover, B: 1 article (07/2008)
6.	Shaikh, Z H A: 1 article (07/2008)
7.	Castillo-Lugo, J A: 1 article (07/2008)
8.	Wright, S E: 1 article (07/2008)
9.	Falavarjani, Khalil Ghasemi: 1 article (06/2008)
10.	Rostami, Hatav: 1 article (06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Abducens Nerve Diseases:

1.	Botulinum Toxins (Botulinum Toxin)IBA 02/01/2001 - "We conclude that botulinum toxin treatment is a safe and effective alternative to traditional surgery of acute onset sixth nerve palsy." 07/01/2000 - "PURPOSE: To study the treatment of sixth nerve palsies of traumatic or tumoral etiologies using botulinum toxin" 09/01/1994 - "Results of a prospective randomized trial of botulinum toxin therapy in acute unilateral sixth nerve palsy." 11/01/1988 - "This study reports the results of treating unrecovered sixth nerve palsy in adults with a combination of botulinum toxin and surgery" 06/01/2008 - "CONCLUSIONS: The effectiveness of botulinum toxin injection is the same with or without EMG assistance into the medial rectus muscle for treatment of abducens nerve palsy" Order ALL the reference details at left...
2.	Botulinum Toxin Type A (Botox)FDA Link 03/01/1994 - "The efficacy of botulinum neurotoxin A for the treatment of complete and partially recovered chronic sixth nerve palsy." 09/01/1994 - "Forty-seven patients entered a prospective randomized trial to assess the effect of early botulinum neurotoxin A treatment to the ipsilateral antagonist medial rectus on the ultimate recovery rate of acute unilateral sixth nerve palsy" 07/01/1989 - "Botulinum A toxin was useful for management of patients with recent surgical overcorrections and for management of some patients with sixth cranial nerve palsy" 12/15/2007 - "Botulinum Toxin type A may have a role in acute or chronic fourth and sixth nerve palsy, childhood strabismus and thyroid eye disease" 10/01/2002 - "BACKGROUND: In a multicenter prospective data collection study of chronic sixth cranial nerve palsy, we previously reported that the initial successful outcome rate was 39% after a single surgical intervention and 25% after surgery combined with botulinum toxin (Botox), using strict success criteria" Order ALL the reference details at left...
3.	EVAC protocol (CAVE)IBA 09/01/2008 - "Spontaneous resolution of a Meckel's cave arachnoid cyst causing sixth cranial nerve palsy." 03/01/2000 - "Hemangiomas of the Meckel cave must be considered in cases of facial pain with a sixth nerve palsy" 03/01/2000 - "In a 25-year-old woman with episodic periorbital-temporal pain who eventually developed a sixth nerve palsy, magnetic resonance imaging revealed a lesion predominantly in the Meckel cave that was found to be a capillary hemangioma arising from the mandibular division of the trigeminal nerve" 03/01/2000 - "Hemangioma of the mandibular branch of the trigeminal nerve in the Meckel cave presenting with facial pain and sixth nerve palsy." Order ALL the reference details at left...
4.	Iopamidol (Isovue)FDA LinkGeneric 12/01/1994 - "The objective of this study was to assess the etiology of lateral rectus palsies in patients undergoing lumbar myelograms with Iopamidol (Isovue; ER Squibb and Sons, Princeton, NJ, USA; Niopam, E Merc, UK.)" 05/19/1990 - "Postmyelographic lateral rectus palsy associated with iopamidol." Order ALL the reference details at left...
5.	Triad FDA Link 04/01/2005 - "A triad of retro-ocular pain, discharging ear and abducens nerve palsy, as described by Gradenigo, has been recognized for 150 years" 11/01/2002 - "A 4-year-old female child was presented with persistent ear discharge, retro-orbital pain and lateral rectus palsy (triad of Gradenigo's syndrome)" 07/01/2003 - "The clinical triad of Gradenigo syndrome consists of acute suppurative otitis media, severe unilateral headache and abducens nerve palsy" 01/01/2003 - "The clinical triad of acute otitis media, pain in the distribution of the fifth cranial nerve and sixth nerve palsy is known as Gradenigo syndrome." 09/01/2000 - "Gradenigo's syndrome, which is characterised by the triad of suppurative otitis media, pain in the distribution of the trigeminal nerve, and abducens nerve palsy may give rise to potentially fatal complications" Order ALL the reference details at left...
6.	tebufenozide (Mimic)IBA 01/01/2000 - "These cardinal signs may mimic neurological conditions, including Parinaud's syndrome, sixth nerve palsy, carotid-cavernous fistula, and spheno-orbital meningioma" 07/01/1999 - "CONCLUSIONS: Diagnosis of DRS in a typical case is not difficult, however, children with bilateral abduction deficits which may mimic DRS must be differentiated from the following four motility disorders, namely, abducens nerve palsy, Moebius' syndrome, congenital oculomotor apraxia, and congenital or infantile esotropia." 10/01/1997 - "CONCLUSIONS: Diagnosis of DRS in a typical case is not difficult, however, children with bilateral abduction deficits which may mimic DRS must be differentiated from the following four motility disorders, namely, abducens nerve palsy, Moebius syndrome, congenital oculomotor apraxia, and congenital or infantile esotropia." Order ALL the reference details at left...
7.	Vincristine (Oncovin)FDA LinkGeneric 02/01/2004 - "Lymphomatous and other intracranial pathologies were excluded, and vincristine neurotoxicity was considered as the possible etiology of the abducens nerve palsy" 02/01/2004 - "Isolated abducens nerve palsy induced by vincristine therapy." 02/01/2004 - "Acute sixth-nerve palsy after vincristine therapy." 02/01/2004 - "We reported a case of acute sixth-nerve palsy occurring soon after administration of vincristine for acute lymphoblastic leukemia (ALL), a previously unreported side effect." Order ALL the reference details at left...
8.	Ethylene Glycol (Monoethylene Glycol)IBA 09/01/2004 - "In our opinion, the patient developed a left abducens nerve palsy and bilateral disc edema secondary to a transient rise in intracranial pressure after ingestion of ethylene glycol." 09/01/2004 - "Papilledema and abducens nerve palsy following ethylene glycol ingestion." Order ALL the reference details at left...
9.	Gadolinium DTPA (Magnevist)FDA Link 01/01/1994 - "Persistent isolated abducens nerve palsy from pontine infarction confirmed by gadolinium-DTPA enhanced MRI]" Order ALL the reference details at left...
10.	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 03/01/2000 - "PURPOSE:To report the association of methylenedioxymetamphetamine (MDMA, "ecstasy") abuse and bilateral sixth nerve palsy" 03/01/2000 - "Bilateral sixth nerve palsy associated with MDMA ("ecstasy") abuse." Order ALL the reference details at left...

Therapies and Procedures

1.	Sutures (Suture) 06/01/2000 - "OBJECTIVE: To evaluate the effect of augmenting full-tendon vertical rectus transpositions with posterior fixation sutures in patients with complete or near-complete lateral rectus palsy" 08/15/1984 - "The authors reported 3 cases of complete lateral rectus palsy treated with the Carlson-Jampolsky transposition technique with readjustable sutures" 03/01/1997 - "CONCLUSIONS: The addition of lateral fixation sutures to full vertical rectus muscle transpositions improves the tonic abducting force of the procedure for patients with lateral rectus palsy and type I Duane syndrome without compromising adduction." 10/01/2008 - "We report a case of traumatic left sixth nerve palsy in a 32-year-old man who developed anterior segment ischemia after left medial rectus muscle recession and partial tendon transfer of the vertical rectus muscles to the lateral rectus, augmented by lateral fixation sutures" Order ALL the reference details at left...
2.	Traction 12/01/2004 - "In both cases, sixth nerve palsies were apparent soon after traction" 11/01/1999 - "In conclusion, it was thought that the mechanism of bilateral abducens nerve palsy in this case was due to the strangulation and the downward traction of the pons-oblongata junction" 03/15/1999 - "OBJECTIVE: This report documents one case of diplopia from abducens (sixth cranial) nerve palsy after spinal surgery using a Jackson table and cranial traction" Order ALL the reference details at left...
3.	Osteotomy 08/01/1988 - "A case of transient abducens nerve palsy following Le Fort I maxillary osteotomy is reported" 08/01/1988 - "Transient abducens nerve palsy following a Le Fort I maxillary osteotomy: report of a case." 06/01/1984 - "A case is reported of a right sided sixth nerve palsy following a maxillary osteotomy at the Le Fort I level" 01/01/2004 - "A 33-year-old female patient developed an ipsilateral sixth nerve palsy and partial third nerve palsy following a Le Fort 1 osteotomy" Order ALL the reference details at left...
4.	Anesthesia 05/01/1989 - "Sixth nerve palsy after lumbar anesthesia." 02/01/1954 - "Abducens nerve palsy following saddle block anesthesia." 02/01/1975 - "Postoperative complications included unintentional first-division analgesia (10), transient sixth-nerve palsy (1), neuroparalytic keratitis (2), and anesthesia dolorosa (2)" Order ALL the reference details at left...
5.	Balloon Occlusion 02/01/2007 - "The patient developed complete third and sixth nerve palsies immediately after detachable balloon embolization of the CCF, which was considered to be caused by cavernous sinus (CS) compression by the over-inflated balloon" 05/01/1983 - "The delayed effects may be summarized as follows: (1) progressive spontaneous occlusion of the fistula after partial balloon embolization, (2) false aneurysms may decrease in size and be spontaneously sealed off, (3) transient and persistent third or sixth cranial nerve palsy may be seen in about 16% of 74 cases, (4) posttraumatic fibrosis with narrowing of the carotid artery may be apparent after total occlusion of the fistula, (5) a prematurely deflated balloon may be dislodged into the carotid artery or its branch, and (6) spontaneous obliteration of common channels from internal carotid artery may occur after total occlusion of external carotid channels in those cases with a combination of internal carotid- and external carotid-cavernous fistulas" Order ALL the reference details at left...

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