Congenital Nystagmus

Nystagmus present at birth or caused by lesions sustained in utero or at the time of birth. It is usually pendular, and is associated with ALBINISM and conditions characterized by early loss of central vision. Inheritance patterns may be X-linked, autosomal dominant, or recessive. (Adams et al., Principles of Neurology, 6th ed, p275)

Also Known As:

Networked: 101 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Retinal Dystrophies
2.	Pathologic Nystagmus
3.	Strabismus (Squint)
4.	Vision Disorders (Hemeralopia)
5.	Cataract (Cataracts)

Experts

1.	Hertle, Richard W: 6 articles (11/2003 - 01/2002)
2.	Pu, Jiali: 4 articles (01/2013 - 01/2011)
3.	Tian, Jun: 4 articles (01/2013 - 01/2011)
4.	Zhang, Baorong: 4 articles (01/2013 - 01/2011)
5.	Yan, Yaping: 3 articles (01/2013 - 02/2011)
6.	Dell'Osso, Louis F: 3 articles (11/2003 - 04/2002)
7.	FitzGibbon, Edmond J: 3 articles (11/2003 - 10/2003)
8.	Lu, Xiaoxiong: 2 articles (01/2013 - 01/2012)
9.	Zhao, Guohua: 2 articles (01/2013 - 01/2012)
10.	Brandt, Thomas: 2 articles (07/2011 - 03/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenital Nystagmus:

1.	Memantine (Namenda)FDA Link 07/01/2006 - "Gabapentin and memantine may be effective in acquired nystagmus secondary to MS. To the authors' knowledge this is the first series of patients showing that gabapentin is effective in improving nystagmus in congenital nystagmus/nystagmus associated with ocular pathology. " 02/01/2007 - "We performed a randomized, double-masked, placebo-controlled study investigating the effects of memantine and gabapentin on congenital nystagmus over a period of 56 days. " 02/01/2007 - "Although studies have shown that memantine and gabapentin can reduce acquired nystagmus, no drug treatment has been systematically investigated in congenital nystagmus. " 02/01/2007 - "Congenital nystagmus: randomized, controlled, double-masked trial of memantine/gabapentin." 09/01/2007 - "Memantine/Gabapentin for the treatment of congenital nystagmus."
2.	Gabapentin (Neurontin)FDA LinkGeneric 07/01/2006 - "Gabapentin and memantine may be effective in acquired nystagmus secondary to MS. To the authors' knowledge this is the first series of patients showing that gabapentin is effective in improving nystagmus in congenital nystagmus/nystagmus associated with ocular pathology. " 02/01/2007 - "We performed a randomized, double-masked, placebo-controlled study investigating the effects of memantine and gabapentin on congenital nystagmus over a period of 56 days. " 02/01/2007 - "Although studies have shown that memantine and gabapentin can reduce acquired nystagmus, no drug treatment has been systematically investigated in congenital nystagmus. " 02/01/2007 - "Congenital nystagmus: randomized, controlled, double-masked trial of memantine/gabapentin." 09/01/2007 - "Memantine/Gabapentin for the treatment of congenital nystagmus."
3.	Diethylpropion (Amfepramone)FDA LinkGeneric 01/01/2002 - "We report a female adult with congenital nystagmus who responded with improved visual function and oculographic parameters after taking the anorexic diet drug Tenuate Dospan (diethylproprionate; Watson Laboratories, Inc., Corona, California). " 01/01/2002 - "Clinical and oculographic response to Tenuate Dospan (diethylpropionate) in a patient with congenital nystagmus." 01/01/2002 - "For unexplained reasons, the anorexic stimulant Tenuate Dospan "paradoxically" improved the nystagmus and binocular function in this patient with congenital nystagmus. "
4.	Dextroamphetamine (Dexedrine)FDA LinkGeneric 01/01/2001 - "For unexplained reasons the stimulant Dexedrine "paradoxically" improved the nystagmus, binocular function and visual acuity in this patient with retinal dystrophy and congenital nystagmus. "
5.	Retinaldehyde (Retinal)IBA 11/01/1995 - "This study determined how contour interaction (the degradation of visual acuity by the presence of nearby contours) is affected by the incessant retinal image motion that occurs in observers with congenital nystagmus (CN). " 01/15/1992 - "Our study suggested an association between a lack of normal decussation of retinal fibers in the optic chiasm, and reversed visual tracking and congenital nystagmus." 11/01/2020 - "Bilateral Macular Myelinated Retinal Nerve Fibers and Congenital Nystagmus." 03/01/2016 - "In congenital nystagmus this can be carried out by optimization of the retinal image, prisms or by bilateral surgical muscle repositioning to use the phenomenon of a null or neutral zone. " 04/01/2006 - "One way to assess the influence of retinal image motion on visual functioning in congenital nystagmus (CN) is to examine the effects of comparable image motion in observers with normal vision. "
6.	Botulinum Toxins (Botulinum Toxin)IBA 10/01/2012 - "[Use of botulinum toxin in a patient with pendular congenital nystagmus]." 09/01/1991 - "Injections of botulinum toxin into the oculomotor muscles was used in incorrectible diplopia, ocular torticollis, Duane's syndrome and congenital nystagmus. " 09/01/1995 - "In the present study, botulinum toxin (Botox) was used to treat congenital nystagmus, injecting the toxin into multiple horizontal rectus muscles at the same treatment session. "
7.	Type A Botulinum Toxins (Botox)FDA Link 01/01/2004 - "Treatment of congenital nystagmus with botulinum toxin A causes reduction of the amplitude of nystagmus, partial improvement of visual acuity and improvement of anomalous head posture." 01/01/2004 - "To evaluate the use of, botulinum toxin A in the treatment of congenital nystagmus in children. " 01/01/2004 - "[Botulinum toxin A in the treatment of congenital nystagmus in children]." 09/01/1995 - "The treatment of congenital nystagmus with Botox." 09/01/1995 - "In the present study, botulinum toxin (Botox) was used to treat congenital nystagmus, injecting the toxin into multiple horizontal rectus muscles at the same treatment session. "
8.	BaclofenFDA LinkGeneric 01/01/1986 - "Congenital nystagmus may respond minimally to drugs (e.g., baclofen), but prisms or surgical procedures, or both, are still the primary treatment modalities. " 07/01/2011 - "A limited number of trials indicate that baclofen improves periodic alternating nystagmus, and that gabapentin and memantine improve acquired pendular and infantile (congenital) nystagmus. "
9.	Monophenol Monooxygenase (Tyrosinase)IBA 04/01/1993 - "Eleven oculocutaneous human albinos (six tyrosinase negative and five oculocutaneous positive), six patients with idiopathic congenital nystagmus, and six normal control subjects participated in the study. "
10.	Proteins (Proteins, Gene)FDA Link 06/01/2013 - "To screen mutations in FERM domain-containing protein 7 (FRMD7) gene in two Chinese families with X-linked idiopathic congenital nystagmus (XLICN). " 01/01/2013 - "The FERM domain containing protein 7 gene (FRMD7) associated with the X-linked disorder idiopathic congenital nystagmus (ICN) is involved in the regulation of neurite elongation during neuronal development. " 01/01/2012 - "Mutations of the FERM domain containing protein 7 gene (FRMD7) are associated with X-linked idiopathic congenital nystagmus. " 01/01/2011 - "FERM domain containing protein 7 (FRMD7) mutations are associated with X-linked idiopathic congenital nystagmus (ICN). " 02/24/2011 - "FERM domain containing 7 (FRMD7) is a member of the four-point-one, ezrin, radixin, moesin (FERM) family of proteins, and has been reported to cause X-linked idiopathic congenital nystagmus (ICN), a disease which affects ocular motor control. "

Therapies and Procedures

1.	Telescopes 11/06/2022 - "Congenital nystagmus (CN), an involuntary, rhythmic, binocular-symmetry, conjugated eye movement, is found at birth or within 3 mo of birth. " 09/01/2003 - "To determine whether patients with congenital nystagmus and an anomalous head posture have better binocular visual acuity than such patients without an anomalous head posture. " 12/01/1992 - "To do so, the horizontal positions of both eyes were recorded by infrared limbal tracking in 4 subjects with congenital nystagmus and 4 normals during monocular and binocular fixation at 200, 40, and 20 cm. At nearer distances, position variability (the standard deviation of horizontal eye position) increased in normal subjects, as well as during foveation periods in the subjects with nystagmus. " 02/01/1987 - "Forty-three patients with congenital nystagmus who underwent surgery in the Ocular Motility Clinic at The Royal Victorian Eye and Ear Hospital, Melbourne, are analysed to assess the effect of different surgical approaches on the abnormal head posture and binocular visual performance. " 06/01/1985 - "Full-field binocular optokinetic responses were examined in patients with congenital nystagmus. "
2.	Sutures (Suture) 06/01/2003 - "Retroequatorial recession of all four horizontal recti using loop sutures is a safe and effective procedure for the management of congenital nystagmus." 06/01/2003 - "The authors wished to evaluate the effectiveness and safety of retroequatorial recession of all four horizontal recti using loop sutures for the treatment of congenital nystagmus Twelve patients with congenital nystagmus were enrolled in this prospective study. " 06/01/2003 - "Retroequatorial recession of horizontal recti with loop suture in the treatment of congenital nystagmus." 10/01/1987 - "[The Cuppers suture in the treatment of congenital nystagmus]." 07/01/1998 - "Extraocular muscle tenotomy, dissection, and suture: a hypothetical therapy for congenital nystagmus."
3.	Psychology Biofeedback (Biofeedback) 10/01/2000 - "The purpose of this study was to evaluate the role of auditory biofeedback in controlling congenital nystagmus. " 08/01/1990 - "A study was made of parameters of congenital nystagmus which responded to auditory biofeedback treatment. " 10/01/2000 - "Ten patients with congenital nystagmus without null position underwent 6 sessions (twice a week for 3 weeks) of auditory biofeedback. " 10/01/2000 - "Reduction of congenital nystagmus amplitude with auditory biofeedback." 08/01/1990 - "Changes in waveform of congenital nystagmus associated with biofeedback treatment."
4.	Therapeutics 07/01/1998 - "Several therapies have been developed for congenital nystagmus (CN) but without placebo-controlled trials. " 09/01/2018 - "This finding expands the spectrum of known gene mutations in idiopathic congenital nystagmus, and may be useful for faster gene diagnosis, prenatal testing, the development of potential gene therapies, and for improving the understanding of the molecular pathogenesis of idiopathic congenital nystagmus." 04/01/2002 - "The use of ocular motor data as the basis for the development of both nonsurgical and surgical therapies for congenital nystagmus (CN) has been underway since the mid-1960s. " 01/01/1989 - "On the variations of the time constant of the slow-phase eye movements produced by surgical therapy of congenital nystagmus: a preliminary report." 07/01/1998 - "Extraocular muscle tenotomy, dissection, and suture: a hypothetical therapy for congenital nystagmus."
5.	Contact Lenses 02/01/2004 - "It has been suggested that contact lens wear improves the visual function of patients with visual loss from congenital nystagmus. " 02/01/2004 - "The use of contact lenses to treat visually symptomatic congenital nystagmus." 08/01/1992 - "The purpose of this report is not to discourage treating patients with congenital nystagmus by means of contact lenses, but rather to draw attention to the occasional occurrence of such a rebound phenomenon and to discuss its theoretical significance." 08/01/1992 - "Symptoms resulting from congenital nystagmus can be significantly reduced by wearing corneal contact lenses. " 08/01/1992 - "Congenital nystagmus: rebound phenomenon following removal of contact lenses."