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Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)

An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
Also Known As:
Muscular Dystrophy, Becker; Becker Muscular Dystrophy; Dystrophy, Duchenne Muscular; Muscular Dystrophy, Duchenne; Childhood Muscular Dystrophy, Pseudohypertrophic; Childhood Pseudohypertrophic Muscular Dystrophy; Duchenne-Type Progressive Muscular Dystrophy; Muscular Dystrophy, Childhood, Pseudohypertrophic; Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type; Muscular Dystrophy, Pseudohypertrophic, Childhood; Progressive Muscular Dystrophy, Duchenne Type; Pseudohypertrophic Childhood Muscular Dystrophy; Pseudohypertrophic Muscular Dystrophy, Childhood; Duchenne Type Progressive Muscular Dystrophy; Dystrophies, Pseudohypertrophic Muscular; Dystrophy, Becker Muscular; Dystrophy, Pseudohypertrophic Muscular; Muscular Dystrophies, Pseudohypertrophic; Pseudohypertrophic Muscular Dystrophies; Pseudohypertrophic Muscular Dystrophy; Muscular Dystrophy, Pseudohypertrophic
Networked: 3772 relevant articles (89 outcomes, 333 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
2. Muscular Dystrophies (Muscular Dystrophy)
3. Cardiomyopathies (Cardiomyopathy)
4. Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
5. Cystic Fibrosis (Mucoviscidosis)

Experts

1. Matsuo, Masafumi: 41 articles (01/2016 - 01/2002)
2. Takeshima, Yasuhiro: 35 articles (01/2016 - 01/2002)
3. Aartsma-Rus, Annemieke: 34 articles (06/2015 - 10/2002)
4. Muntoni, Francesco: 33 articles (05/2015 - 07/2002)
5. Takeda, Shin'ichi: 33 articles (05/2015 - 03/2002)
6. Chamberlain, Jeffrey S: 32 articles (12/2014 - 03/2002)
7. Duan, Dongsheng: 30 articles (12/2015 - 03/2002)
8. Davies, Kay E: 30 articles (12/2015 - 04/2002)
9. Hoffman, Eric P: 30 articles (09/2015 - 08/2002)
10. Flanigan, Kevin M: 30 articles (06/2015 - 04/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Duchenne Muscular Dystrophy:
1. DystrophinIBA
2. Creatine Kinase (Creatine Phosphokinase)IBA
3. Prednisolone (Predate)FDA LinkGeneric
4. Prednisone (Sone)FDA LinkGeneric
5. Adrenal Cortex Hormones (Corticosteroids)IBA
6. Growth Hormone (Somatotropin)IBA
7. UtrophinIBA
8. Proteins (Proteins, Gene)IBA
9. SteroidsIBA
10. RNA Precursors (Precursor, mRNA)IBA

Therapies and Procedures

1. Artificial Respiration (Mechanical Ventilation)
2. Transplantation (Transplant Recipients)
3. Tissue Therapy (Cell Therapy)
4. Therapeutics
5. Intermittent Positive-Pressure Ventilation