Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)

2615  relevant articles (52 outcomes, 220 trials/studies) found for this Disease

Muscular Dystrophy, Becker; Becker Muscular Dystrophy; Dystrophy, Duchenne Muscular; Muscular Dystrophy, Duchenne; Childhood Muscular Dystrophy, Pseudohypertrophic; Childhood Pseudohypertrophic Muscular Dystrophy; Duchenne-Type Progressive Muscular Dystrophy; Muscular Dystrophy, Childhood, Pseudohypertrophic; Muscular Dystrophy, Pseudohypertrophic, Childhood; Progressive Muscular Dystrophy, Duchenne Type; Pseudohypertrophic Childhood Muscular Dystrophy; Pseudohypertrophic Muscular Dystrophy, Childhood; Duchenne Type Progressive Muscular Dystrophy; Dystrophies, Pseudohypertrophic Muscular; Dystrophy, Becker Muscular; Dystrophy, Pseudohypertrophic Muscular; Muscular Dystrophies, Pseudohypertrophic; Pseudohypertrophic Muscular Dystrophies; Pseudohypertrophic Muscular Dystrophy; Muscular Dystrophy, Pseudohypertrophic

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker)
2.	Muscular Dystrophies (Muscular Dystrophy)
3.	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
4.	Muscular Diseases (Myopathy)
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

Experts

1.	Matsuo, Masafumi: 11 articles (05/2008 - 09/2002)
2.	Takeshima, Yasuhiro: 9 articles (05/2008 - 03/2004)
3.	Yagi, Mariko: 7 articles (05/2008 - 03/2004)
4.	Ishikawa, Y: 5 articles (07/2007 - 10/2000)
5.	Iannaccone, Susan T: 4 articles (12/2007 - 03/2002)
6.	Zhang, Cheng: 4 articles (10/2007 - 03/2005)
7.	Chamberlain, Jeffrey S: 4 articles (06/2007 - 03/2002)
8.	Tremblay, Jacques P: 4 articles (01/2007 - 03/2004)
9.	Takeshima, Y: 4 articles (10/2005 - 03/2000)
10.	Matsuo, M: 4 articles (10/2005 - 03/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Duchenne Muscular Dystrophy:

1.	DystrophinIBA 07/01/1997 - "Hopes ran high that a cure for Duchenne muscular dystrophy (DMD) would quickly follow the discovery of dystrophin by Lou Kunkel and his group in the 1980's" 01/01/2007 - "BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused by mutations of dystrophin gene, there is no effective treatment for this disorder at present" 03/01/2004 - "Despite a wealth of recent information about the molecular basis of Duchenne muscular dystrophy (DMD), there is no effective treatment for this condition because the mechanism how dystrophin deficiency produces the muscle fiber degradation is unknown" 03/01/1992 - "An improved method by quantitative dystrophin gene deletion analysis was developed for the detection of Duchenne/Becker muscular dystrophy (DMD/BMD) carriers" 08/01/1989 - "Improved diagnosis of Becker muscular dystrophy by dystrophin testing." Order ALL the reference details at left...
2.	Creatine Kinase (Creatine Phosphokinase)IBA 06/01/1989 - "While diagnosis is still unacceptably late in most cases, it can be improved if all boys with this pattern of developmental delay are screened for Duchenne muscular dystrophy by measurement of creatine kinase activity." 02/01/1982 - "The mean serum creatine kinase levels before and after exercise, as well as the mean increases, were found to be significantly greater in Duchenne muscular dystrophy carriers than in normal control subjects." 01/01/1987 - "Data obtained from simultaneous determinations of serum creatine-kinase levels and estimation of ultrasound attenuation values in muscles greatly improved the detection of obligate carriers of Duchenne muscular dystrophy than when only one of these methods was employed alone" 01/01/1986 - "Screening for Duchenne muscular dystrophy: an improved screening test for creatine kinase and its application in an infant screening program." 01/01/1983 - "Improved detection of Duchenne muscular dystrophy heterozygotes using discriminant analysis of creatine kinase levels." Order ALL the reference details at left...
3.	Prednisone (Sone)FDA LinkGeneric 08/01/2002 - "The recent introduction of pharmaceutical agents such as prednisone has shown great promise in delaying the progression of Duchenne muscular dystrophy but there remains a need to develop more long-term therapeutic interventions" 02/01/2003 - "The purpose of this long-term, open parallel-group, double-consent study of alternate-day, low-dose prednisone in 2-4-year-old patients with Duchenne muscular dystrophy (DMD) was to determine whether prednisone produces a beneficial effect when given earlier than usual" 12/01/1991 - "Two successive, 6-month, randomized, double-blind, controlled trials of prednisone showed that 0.75 mg/kg/d was the optimal dose to improve strength in boys with Duchenne muscular dystrophy (DMD)" 06/01/1991 - "We previously reported the results of a randomized, double-blind 6-month trial of prednisone therapy in which 102 boys aged 5 to 15 years with Duchenne muscular dystrophy received daily doses of 1.5 and 0.75 mg/kg per day and were compared with those receiving placebo" 05/01/1991 - "This study suggests that prednisone may improve strength in Duchenne muscular dystrophy through primarily immunologic mechanisms involving T lymphocytes." Order ALL the reference details at left...
4.	UtrophinIBA 02/15/2004 - "Utrophin has been studied extensively in recent years in an effort to find a cure for Duchenne muscular dystrophy" 01/01/2004 - "These results have important implications for future studies aiming to effect therapeutic utrophin up-regulation in Duchenne muscular dystrophy patients." 10/01/2002 - "Previous studies on transgenic mice indicate that upregulation of utrophin protein may offer a potential treatment strategy for Duchenne muscular dystrophy" 05/15/2006 - "We investigated in diagnostic muscle biopsies from 16 patients with Duchenne muscular dystrophy (DMD) the level of utrophin expression using quantitative immunoblot analysis" 05/15/2006 - "Naturally occurring utrophin correlates with disease severity in Duchenne muscular dystrophy." Order ALL the reference details at left...
5.	Prednisolone (Predate)FDA LinkGeneric 01/01/2008 - "Remission of clinical signs in early Duchenne muscular dystrophy on intermittent low-dosage prednisolone therapy" 01/01/2002 - "Remission of clinical signs in early duchenne muscular dystrophy on intermittent low-dosage prednisolone therapy." 04/01/2001 - "A total of 19 Duchenne muscular dystrophy (DMD) patients were recruited for randomized controlled study to see the effect of prednisolone in the natural course of the disease process" 05/01/1995 - "Forty-one boys, aged 4.0-19.4 yr, with Duchenne or Becker muscular dystrophy, took part in a 12-month randomized, double-blind cross-over trial in which the patients received 0.35 mg kg-1 day-1 prednisolone for six months and placebo for six months" 01/01/2007 - "We have demonstrated long-term benefit of oral prednisolone in the mdx mouse model of Duchenne muscular dystrophy (DMD)" Order ALL the reference details at left...
6.	Mazindol (Mazanor)FDA Link 12/01/1989 - "A simple-blind therapeutic trial of mazindol (2 mg/d) versus placebo in 14 boys with Duchenne muscular dystrophy, 5 to 13 years old, for 12 months was conducted in order to analyse the efficacy of this drug on the natural history of the disease" 12/01/1989 - "A therapeutic trial of mazindol versus placebo in Duchenne muscular dystrophy" 01/23/1988 - "Mazindol in Duchenne muscular dystrophy." 12/01/1988 - "Mazindol has been reported to improve muscle function in Duchenne muscular dystrophy (DMD) by virtue of its growth hormone (GH) suppression" 07/01/1986 - "A controlled, double-blind therapeutic trial with the drug mazindol, a growth hormone inhibitor, was performed in a pair of 7 1/2 year-old monozygotic twins, with Duchenne muscular dystrophy (DMD)" Order ALL the reference details at left...
7.	Growth Hormone (Somatotropin)IBA 12/01/2003 - "Duchenne muscular dystrophy with associated growth hormone deficiency." 10/01/1988 - "Growth hormone evaluation in Duchenne muscular dystrophy." 07/01/1986 - "Treatment of Duchenne muscular dystrophy with growth hormone inhibitors." 07/01/1986 - "Benign Duchenne muscular dystrophy in a patient with growth hormone deficiency: a five years follow-up." 01/01/1981 - "Benign Duchenne muscular dystrophy in a patient with growth hormone deficiency." Order ALL the reference details at left...
8.	Glycoproteins (Glycoprotein)IBA 01/01/1989 - "An RCA I-lectin binding glycoprotein of Mr = 370 kD is missing from or altered in the plasma membrane of Duchenne muscular dystrophy (DMD) skeletal muscle" 05/01/1985 - "Identification of a high molecular weight glycoprotein which is absent or altered in Duchenne muscular dystrophy." 11/01/2002 - "nNOS, anchored to the sarcolemma through its interactions with the dystrophin-glycoprotein complex, is dramatically reduced in dystrophin-deficient mdx mice and Duchenne muscular dystrophy patients" 11/03/2008 - "Mutations in the dystrophin gene cause Duchenne muscular dystrophy and result in the loss of dystrophin and the entire dystrophin-glycoprotein complex (DGC) from the sarcolemma" 02/01/2006 - "In this report, we have developed a novel method to identify compounds that rescue the dystrophin-glycoprotein complex (DGC) in patients with Duchenne or Becker muscular dystrophy" Order ALL the reference details at left...
9.	Human Growth Hormone (Saizen)FDA LinkGeneric 08/01/1989 - "Human growth hormone (hGH) inhibition may be beneficial for Duchenne muscular dystrophy (DMD) patients and slow the rate of progression of the disease" 12/01/1988 - "Human growth hormone (HGH) inhibition may be beneficial in Duchenne muscular dystrophy (DMD) and slow down the rate of progression of the disease" 02/01/1974 - "Human growth hormone in myopathy: myotonic dystrophy, duchenne muscular dystrophy, and limb-girdle muscular dystrophy." 06/01/1973 - "Human growth hormone and estrogens in boys with Duchenne muscular dystrophy." 05/01/1972 - "Metabolic effects of human growth hormone and of estrogens in boys with Duchenne muscular dystrophy." Order ALL the reference details at left...
10.	Complementary DNA (cDNA)IBA 05/01/2004 - "Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients." 03/15/2003 - "cDNA microarray analysis of individual Duchenne muscular dystrophy patients." 01/01/1999 - "Detection of gene deletions in Chinese patients with Duchenne/Becker muscular dystrophy using CDNA probes and the polymerase chain reaction method." 03/27/1998 - "Especially 3.7 kbp cDNA for deltaDysM3 offers the possibility of an approach utilizing newly developed virus vectors, such as an adeno-associated virus vector, toward gene therapy of Duchenne muscular dystrophy." 01/01/1995 - "We present molecular data from 90 Greek boys with Duchenne or Becker muscular dystrophy using cDNA analysis or multiplex PCR or both" Order ALL the reference details at left...

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 12/01/2004 - "The aim of this study was to investigate the clinical feasibility of adult stem cell transplantation for lethal mono-gene inherited disease, Duchenne muscular dystrophy (DMD)" 01/01/2001 - "The clinical trials of myoblast transplantation in Duchenne Muscular Dystrophy (DMD) patients produced disappointing results" 03/01/1993 - "Results of a triple blind clinical study of myoblast transplantations without immunosuppressive treatment in young boys with Duchenne muscular dystrophy." 01/01/2007 - "BACKGROUND: The value of transplantation of BM stem cells in aged (12-month-old) mdx was evaluated because it is thought to be a more ideal model for studying the praxiology of Duchenne muscular dystrophy (DMD)" 01/01/2007 - "Construction of recombinant adenovirus, which contain human microdystrophin, and then transfection into mesenchymal cells( MSCs) of mdx mice were done, and genetically-corrected isogenic MSCs were acquired; the MSCs transplantation into the mdx mice was then done to treat the Duchenne muscular dystrophy( DMD)" Order ALL the reference details at left...
2.	Transplants (Transplant) 07/01/1982 - "Light-microscopic study of muscles from 8 patients with Duchenne muscular dystrophy (DMD) and 9 control cases transplanted into nude mice showed the formation of cross-striations and peripheral nuclei in regenerating muscle fibers of both DMD and control grafts up to 4 weeks" 06/01/2005 - "The quantification of the graft success is a key element to evaluate the efficiency of cellular therapies for several pathologies such as Duchenne muscular dystrophy" 01/01/1994 - "Experimental challenge for the treatment of Duchenne muscular dystrophy using a vascularized free muscle graft." 04/01/2002 - "Successful therapy suggests a trial of medical therapy may be beneficial when patients with Becker muscular dystrophy-related cardiomyopathy are evaluated for transplant." 04/01/2002 - "Patients with Becker muscular dystrophy-related cardiomyopathy typically survive into their 30s, when they succumb to complications of cardiomyopathy or receive heart transplants" Order ALL the reference details at left...
3.	Intermittent Positive-Pressure Ventilation 09/01/2006 - "The present study aimed to assess the impact of diurnal mouthpiece intermittent positive pressure ventilation (MIPPV) as the extension of the nasal intermittent positive pressure ventilation (NIPPV) in Duchenne muscular dystrophy (DMD)" 09/01/2005 - "We have been introducing the intermittent positive pressure ventilation (IPPV) therapy in Duchenne muscular dystrophy (DMD) since 1990" 09/01/2005 - "Effect of intermittent positive pressure ventilation on life-span and causes of death in Duchenne muscular dystrophy]" 06/01/2002 - "OBJECTIVE: To quantitate prolongation of survival for patients with Duchenne muscular dystrophy with the use of noninvasive intermittent positive-pressure ventilation (IPPV) with and without access to a protocol involving mechanically assisted coughing" 02/01/1987 - "Mouth intermittent positive pressure ventilation alone or in combination with other techniques of ventilatory assistance can prolong life while allowing optimal function, attainment of higher levels of education, and home management of patients with Duchenne muscular dystrophy." Order ALL the reference details at left...
4.	Immunotherapy 03/01/2003 - "Prior studies and the efficacy of immunotherapies provide evidence that inflammation is mechanistic in pathogenesis of Duchenne muscular dystrophy" 10/01/2005 - "New brief reports this month include: Strategies for Duchenne Muscular Dystrophy: Various approaches are being explored to abate the dystrophic process including cellular therapies (transplanting stem cells or myogenic precursors into muscles), molecular approaches (delivering a functional or correcting the mutant dystrophin gene), such as MyoDys, Biostrophin(R) and antisense technology, and pharmacotherapeutics, which include calcium channel blockers, calpain inhibitors, phosphodiesterase inhibitors and monoclonal antibodies; Immunotherapy for Multiple Myeloma: Increasing numbers of antibodies and immunoconjugates with anticancer drugs are entering clinical development; Acute respiratory distress syndrome is among the most frequent reasons for intensive care" Order ALL the reference details at left...
5.	Tissue Therapy (Cell Therapy) 02/01/2008 - "Cell therapy for Duchenne muscular dystrophy and other muscle diseases is limited by a massive early cell death following injections" 12/01/2006 - "Cell therapy for Duchenne muscular dystrophy]" 12/01/2006 - "CSCI/RCPSC Henry Friesen Lecture: Cell therapy for Duchenne muscular dystrophy." 01/01/2005 - "Cell therapy prospects in Duchenne muscular dystrophy]" 06/01/2001 - "Myoblast transfer therapy (MTT) is a potential cell therapy for myopathies such as Duchenne Muscular Dystrophy and involves the injection of cultured muscle precursor cells ('myoblasts') isolated from normal donor skeletal muscles into dystrophic host muscle" Order ALL the reference details at left...